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Electronics Core is electronics design, development and repair facility which specializes in proof-of-concept design and prototyping, and early stage development of medical devices and laboratory research instrumentation. Services include system design, schematic capture, printed circuit board layout, board fabrication, assembly and testing.
International registry of institutional open access mandates. Total Mandates to Date (by type) (2013): * Institutional Mandates (166) * Sub-Institutional Mandates (36) * Multi-Institutional Mandates (4) * Funder Mandates (80) * Thesis Mandates (101) * Proposed Institutional Mandates (6) * Proposed Sub-Institutional Mandates (4) * Proposed Multi-Institutional Mandates (6) * Proposed Funder Mandates (11)
Software R package to run minimum hypergeometric test.
Database for exploring genomic variation data within African populations.
A web portal that provides access to data, tools and materials that will aid in craniofacial research. Included is access to genomic and imaging based data sets from a variety of species, including zebrafish, human and mouse.
Facility provides cytometry and cell sorting services. Services include immunophenotyping, cell cycle analysis, and intracellular fluorophore detection. Services can be tailored to research needs, certified cytometrists are available to help plan experiments. Offers online and hands-on training in use of cell analyzers and analysis software.
Cogentech's CGT lab is offering its diagnostic services for Hereditary Tumors (Cancer Risk) and for Personalized Medicine (Therapy) to clinicians, laboratories and hospitals.
A database housing EST information from nine mollusc species, including Lymnaea stagnalis, the pond snail. Co-curated with Angus davison of Nottingham University.
Open source community driven guide to reproducible, ethical, inclusive and collaborative data science. Provides information that data scientists in academia, industry and government need at start of their projects to ensure that they are easy to reproduce and reuse at the end. Expanded to series of books covering reproducible research, project design, communication, collaboration, and ethical research.
Software R package for estimation of causal mediation effects. Allows researchers to conduct sensitivity analysis for certain parametric models.
The W. M. Keck Foundation was established in 1954 in Los Angeles by William Myron Keck, founder of The Superior Oil Company. Our Foundation is one of the nation''s largest philanthropic organizations, with assets of more than $1billion. Mr. Keck envisioned a philanthropic institution that would provide far-reaching benefits for humanity. By taking a bold, creative approach to grantmaking, he created a legacy that the Foundation proudly upholds today. In recent years, the Foundation has focused on Science and Engineering Research; Medical Research; Undergraduate Education; and Southern California. Each of our grant programs invests in people and programs that are making a difference in the quality of life, now and for the future. Supporting pioneering discoveries in science, engineering and medical research has been our mandate for a half-century. By funding the work of leading researchers, the establishment of unique laboratories and research centers, and the purchase of sophisticated instruments, we are laying the groundwork for breakthrough discoveries and new technologies that will save lives, provide innovative solutions to complex problems and add immeasurably to our understanding of life on Earth and our place in the universe. We believe that a high-quality, well-rounded college education is vital for tomorrow''s leaders. The Foundation''s undergraduate education program promotes inventive approaches to instruction and effective involvement of students in research at colleges across the nation. Our support of Southern California-based organizations enriching the lives of our region''s residents has expanded and deepened over the years. We place a special emphasis on children, youth and their families, with the goal of providing safe, healthy, supportive environments that prepare children to succeed in school and in life.
Software tool for de novo detection of full length LTR retrotransposons in large sequence sets. Delivers high quality annotations based on known LTR transposon features like length, distance, and sequence motifs.
Open-source, cross-platform FTP application, consisting of FileZilla Client and FileZilla Server. Clients are available for Windows, Linux, and macOS. Both server and client support FTP and FTPS (FTP over SSL/TLS), while the client can in addition connect to SFTP servers. Used to transfer files between local computer and remote server. It facilitates uploading and downloading files, making it popular for managing website files and web hosting.
Clearinghouse and exchange portal for gene variant (mutation) data produced by diagnostics laboratories, offering users a portal through which to announce, discover and acquire a comprehensive listing of observed neutral and disease-causing gene variants in patients and unaffected individuals. Cafe Variome is not a ''''database'''' for the hosting/display/release of data, but a shop window for finding data. As such, it holds only core info for each record, and uses this merely to enable holistic searching across resources. Diagnostics laboratories routinely assess DNA samples from patients with various inherited disorders, and so produce a great wealth of data on the genetic basis of disease. Unfortunately, those data are not usually shared with others. To address this gross deficiency, a novel system has been developed that aims to facilitate the automated transfer of diagnostic laboratory data to the wider community, via an internet based Cafe for routinely exchanging genetic variation data. The flow of research data concerning the genetic basis of health and disease is critical to understanding and developing treatments for a range of genetic diseases. Overall, the project aims to lower the barriers and provide incentives for a willing community to share data, and thereby facilitate the broader exploitation of diagnostic laboratory data. Cafe Variome aims to address the above data flow problems by: # Minimizing the effort required to publish variant data # Ensuring attribution for data creators working in diagnostic laboratories Key elements of the project strategy are: * Data publication will be automated by endowing standard analysis tools used by laboratories with an online data submission function. Submissions will be received by a central Internet depot, which will serve as a place where published datasets are advertised, and subsequently discovered by diverse 3rd parties. * Each dataset will be unambiguously linked with the data submitter''''s identity, and systems devised to facilitate citation of published variant datasets so they can be cited in the literature. Data creators will thus be credited for their contributions. Data submitters can use Cafe Variome to simply announce or publicize their data to the world. To enable this, only core, non-identifiable data is submitted to the central repository, enabling users to search and discover records of interest in the source repository. The data are not automatically handed on to the user (unless intended by the submitters). Hence, the concept is used to deal with the challenge of maximally sharing data whilst fully respecting ethico-legal considerations.
Provided core services include Sanger DNA Sequencing, Next Generation DNA Sequencing (Four Illumina MiSeqs, four Illumina NextSeq 500s and one Illumina NovaSeq 6000),Next Generation Automated Library Sample Prep (Perkin Elmer Sciclone Genomic, ChIP, RNAseq and other methods), Single Cell DNA and RNA-Seq (10X Genomics Chromium), Bioanalyzer Analysis DNA and RNA (Two Agilent 2100 BioAnalyzers and two Agilent 2200 TapeStations), Qiagen Qiacube Automated DNA / RNA Prep (single to multiple samples), Oligonucleotide Ordering (IDT Portal), Reagents and Supplies Ordering (multiple vendors / products). Facility web based Laboratory Information Management System provides users with access to order services and supplies as well as retrieve data and review and pay invoices all online.
Provides access to imaging technology. Offers combination of both commercial platforms and not-yet commercialized technologies that enable innovative research centered around structural and functional imaging. Optical microscopy and image analysis platform.
Provides standardized vocabulary of phenotypic abnormalities encountered in human disease. Structured and controlled vocabulary for phenotypic features encountered in human hereditary and other disease. HPO is being developed in collaboration with members of OBO Foundry (Open Biological and Biomedical Ontologies), and logical definitions for HPO terms are being developed using PATO and a number of other ontologies including FMA, GO, ChEBI, and MPATH.
Expert curated resource that provides framework for integration of lipid and lipidomic data with biological knowledge and models. Provides curated knowledge of lipid structures and metabolism which is used to generate in silico library of feasible lipid structures. These are arranged in hierarchical classification that links mass spectrometry analytical outputs to all possible lipid structures, metabolic reactions and enzymes. Provides reference namespace for lipidomic data publication, data exploration and hypothesis generation.
Core designed for range of solution-state pharmaceutical and biological chemistry applications. Facility is equipped with 600 MHz magnet equipped with high-throughput autosampler and QCI-F cryoprobe optimised for 1H and 19F sensitivity, and 400 MHz magnet dedicated to routine chemistry applications. Facility is also operating ligand-observed 19F-fragment library screening service for drug discovery.
A database of elecrophysiological properties text-mined from the biomedical literature as a function of neuron type. Specifically, NeuroElectro seeks to extract information about the electrophysiological properties (e.g. resting membrane potentials and membrane time constants) of diverse neuron types from the existing literature and place it into a centralized database. There are 252 neurons currently available, with the naming convention established in NeuroLex.