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Core facility that provides the following services: In-gel protease digestion service, LC-MS/MS protein identification service, Gel/LC-MS/MS Comprehensive analysis of a subproteome or proteome, MudPIT (LC/LC-MS/MS) analyis?comprehensive analysis of a subproteome or proteome, Reverse phase microbore HPLC peptide mapping service, MALDI mass spectrometry, ESI of intact proteins, Post-translational modification identifications, Custom proteomics database creation, Custom proteomics data analysis, Proteomics methods development. The Wistar Proteomics Facility provides mass spectrometry (MS) and sequence analysis of proteins and peptides at maximum sensitivity using state-of-the-art instruments and methods. The most commonly used services are identifications of either purified proteins or complex protein mixtures, such as sub-proteomes or complete proteomes, using electrospray ionization tandem mass spectrometry (ESI MS/MS). Typically, either individual bands are excised from 1-D SDS gels, or the entire gel lane is analyzed by slicing it into uniform fractions followed by trypsin digestion and nanocapillary HPLC interfaced directly with hybrid ion trap mass spectrometry (Gel/LC-MS/MS). Data is analyzed and filtered to produce low false-positive rates. Several options are available for quantitatively comparing protein changes in related samples, and additional options will be implemented in the future. Complementary services include reverse-phase microbore HPLC peptide mapping with UV detection and mass measurements of intact peptides and proteins using MALDI MS or ESI MS. Posttranslational modification (PTM) analyses including identifications of specific modified residues also are provided, although investigators should recognize that in most cases these studies are quite complex and require substantial effort. These studies, as well as analyses of complex protein mixtures, usually require preparation of custom sequence databases and/or custom data analyses, which can be provided by the facility as needed.

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• SciCrunch
• 13 years ago - by Anonymous

Ontology of Medical Diagnostic Categories-Diagnosis Related Groups

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented September 18, 2017. Text Mining platform that copes with major Information Retrieval and Information Extraction tasks and promotes multi-disciplinary research. It aims to provide support to three different usage roles: biologists, text miners and application developers. The workbench supports the retrieval, processing and annotation of documents as well as their analysis at different levels.

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• SciCrunch
• 13 years ago - by Anonymous

Organization that works with knowledge professionals to create, support and deliver programs, services and technologies that allow for equitable access to world knowledge and cultural heritage. Hosts data-migration, content licensing, and community supported soft​ware programs for libraries, archives, museums and research organizations worldwide.​​​

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• RRID
• 2 years ago - submitted by Anita Bandrowski

Organization that develops methods, works with leaders and teams, and provides education and training to help organizations improve their products and services and to build their capability for on-going improvement.

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• SciCrunch
• 13 years ago - by Anonymous

Collection of manually curated data regarding structure and antimicrobial activity of natural and synthetic peptides. Provides the information and analytical resources to develop antimicrobial compounds with the high therapeutic index.

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• dkNET
• 8 years ago - submitted by Ko-Wei Lin

Core facility dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, French Translation, 2001

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• SciCrunch
• 13 years ago - by Anonymous

Platform for analyzing and sharing neuroimaging data from human brain imaging research studies. Brain Imaging Data Structure ( BIDS) compliant database. Formerly known as OpenfMRI.

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• RRID-Legacy
• 8 years ago - submitted by Anita Bandrowski

Core provides services to produce and preserve genetically engineered mouse strains for animal model research.Supports animal model research endeavors, to advance genetic and reproductive technologies for model creation and preservation, and to serve as resource for design, development and derivation of customized mouse strains.

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• RRID
• 2 years ago - submitted by Phillip Deyerle

Project aiming to tackle bottlenecks in Alzheimer''''s disease research and drug discovery by developing and validating new tools to test candidate drugs for the treatment of symptoms and disease in a faster and more sensitive way. They will provide the tools needed to define more precisely the potential of a drug candidate, reduce the development time of new medicines and thus accelerate the approvals of promising new medicines. By bringing together databases of previously conducted clinical trials and combining the results from blood tests, brain scans and behavioral tests, the scientists will develop a ''''signature'''' that gives more accurate information on the progression of the disease and the effect of candidate drugs than current methods do. The scientists will conduct parallel studies in laboratory models, healthy volunteers and patients in order to better predict good new drugs as early as possible. This will enable them, for instance, to find out how memory loss in Alzheimer''''s disease can be simulated in healthy volunteers, for example with sleep deprivation or drugs that temporarily affect the memory, in order to test the effect of candidate-medicines early in the drug development process.

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• Consortia-pedia, a FasterCures Project
• 13 years ago - by Anonymous

Software for a workflow for amplicon sequencing from mixed microbial communities on the nanopore sequencing platform. Used for full-length SSU rRNA gene sequencing.

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• RRID-Legacy
• 8 years ago - submitted by Szymon Calus

Facility where IUSM and external investigators can request studies within broad spectrum of rodent behavioral paradigms. Housed on the fourth and fifth floors of Stark Neurosciences Research Institute in the Neurosciences Research Building, the core, available to all IU School of Medicine investigators. Core validates all assays; allows for testing of pharmacological or other manipulations to study disease models; incorporates necropsy endpoints to behavioral assays as needed; provides guidance on interpretation and analysis of data.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

A structured controlled vocabulary of mutant and transgenic mouse pathology phenotypes

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• SciCrunch
• 13 years ago - by Anonymous

Software package for molecular modeling. Computes free energy changes using free energy perturbation method. Used to examine molecular conformations, molecular motion, and intermolecular interactions, such as those in a ligand-receptor complex.

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• RRID-Legacy
• 8 years ago - submitted by Anita Bandrowski

Mechanisms of Behavior Core offers the equipment, reagents, bench space, and expertise to answer questions related to the roles of genetics and hormones in relation to animal behavior.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

A distributed framework and cyberinfrastructure for open, persistent, and secure access to Earth observational data. It ensures the preservation, access, use and reuse of multi-scale, multi-discipline, and multi-national science data via three primary cyberinfrastucture elements and a broad education and outreach program. The DataONE Investigator Toolkit is a collection of software tools for finding, using, and contributing data in DataONE. DataONE currently hosts three Coordinating Nodes that provide network-wide services to enhance interoperability of the Member Nodes and support indexing and replication services. Coordinating Nodes provide a replicated catalog of Member Node holdings and make it easy for scientists to discover data wherever they reside, also enabling data repositories to make their data and services more broadly available to the international community. DataONE Coordinating Nodes are located at the University of New Mexico, the University of California Santa Barbara and at the University of Tennessee (in collaboration with Oak Ridge National Laboratory). DataONE comprises a distributed network of data centers, science networks or organizations. These organizations can expose their data within the DataONE network through the implementation of the DataONE Member Node service interface. In addition to scientific data, Member Nodes can provide computing resources, or services such as data replication, to the DataONE community.

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• SciCrunch
• 13 years ago - by Anonymous

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• SciCrunch
• 8 years ago - submitted by sk paul

Core that provides spectrum of advanced cellular and tissue pathology and imaging services for diabetes researchers at Columbia University. It also has microscopy equipment and services such as confocal, live 2-photon and scanning and transmission electron microscopy.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Cancer Research UK is UK's largest charity funding cancer research. Cancer Research UK is a registered charity in England and Wales (1089464) and in Scotland (SC041666). Registered as a company limited by guarantee in England & Wales No. 4325234.

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• SciCrunch
• 16 years ago - by Anonymous