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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials InformationDatabase | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Clinicaltrials.gov | Changes in Breast Density and Blood Hormone Levels in Postmenopausal Women Receiving Anastrozole or Exemestane for Breast Cancer | Completed | Breast Cancer | Genetic, Other, Other, Procedure - polymorphism analysis, high performance liquid chromatography, laboratory biomarker analysis, radiomammography | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - N/A | Observational | RATIONALE: Studying changes in breast density and blood hormone levels in women receiving anastrozole or exemestane for breast cancer may help doctors learn more about the long-term effects of treatment and may help the study of breast cancer in the future. PURPOSE: This clinical trial is studying changes in breast density and blood hormone levels in postmenopausal women receiving anastrozole or exemestane for breast cancer. | ||
Clinicaltrials.gov | Studying Genes for Barrett's Esophagus in Brothers and Sisters | Unknown status | Esophageal Cancer, Precancerous Condition | Genetic, Genetic, Other, Other, Procedure - comparative genomic hybridization, genetic linkage analysis, laboratory biomarker analysis, questionnaire administration, study of high risk factors | Medical Research Council, Other | N/A - N/A | Observational | RATIONALE: Learning about how often heartburn and other risk factors occur in brothers and sisters and other family members of patients with Barrett's esophagus may help identify other individuals at risk and identify genes for Barrett's esophagus. PURPOSE: This clinical trial is studying genes for Barrett's esophagus in brothers and sisters. | |||
Clinicaltrials.gov | Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy | Terminated | Brain and Central Nervous System Tumors, Thrombocytopenia | Drug, Genetic, Genetic, Other, Other, Radiation - temozolomide, comparative genomic hybridization, polymorphism analysis, laboratory biomarker analysis, pharmacological study, radiation therapy | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Other, NIH | 18 Years - 120 Years | Observational | RATIONALE: Studying samples of blood in the laboratory from patients receiving temozolomide may help doctors learn how temozolomide works in the body. It may also help doctors learn more about how a patient's genes may affect the risk of developing thrombocytopenia. PURPOSE: This clinical trial is studying the pharmacokinetics in patients with newly diagnosed high-grade glioma receiving temozolomide and radiation therapy. | |||
Clinicaltrials.gov | Depression and Interleukin-6 Production in Patients With Ovarian Epithelial Cancer | Withdrawn | Depression, Fatigue, Ovarian Cancer, Psychosocial Effects of Cancer and Its Treatment, Sleep Disorders | Genetic, Other, Other, Other, Procedure, Procedure, Procedure - polymorphism analysis, laboratory biomarker analysis, physiologic testing, questionnaire administration, conventional surgery, fatigue assessment and management, psychosocial assessment and care | Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - 55 Years | Observational | RATIONALE: Measuring levels of interleukin-6 and depression may help doctors understand the relationship between interleukin-6 and depression. It may also help the study of cancer in the future. PURPOSE: This clinical trial is studying depression and interleukin-6 production in patients with ovarian epithelial cancer. | ||
Clinicaltrials.gov | Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma | Unknown status | Hereditary Multiple Melanoma, Melanoma (Skin) | Genetic, Genetic, Genetic, Genetic, Other, Procedure, Procedure - gene expression analysis, microarray analysis, molecular genetic technique, mutation analysis, laboratory biomarker analysis, mutation carrier screening, study of high risk factors | Leeds Cancer Centre at St. James's University Hospital, Other | N/A - N/A | Observational | RATIONALE: Identifying gene mutations and other risk factors in patients with melanoma and in families with a history of hereditary melanoma may help doctors identify persons at risk for melanoma and other types of cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is studying gene mutations in patients with melanoma and in families with a history of hereditary melanoma. | |||
Clinicaltrials.gov | Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery | Completed | Thromboembolism, Unspecified Adult Solid Tumor, Protocol Specific | Other, Other, Other, Other, Procedure - coagulation study, immunoenzyme technique, laboratory biomarker analysis, physiologic testing, study of high risk factors | National Cancer Institute (NCI), NIH | 18 Years - N/A | Observational | RATIONALE: A test that detects abnormal blood clotting in patients with cancer may help doctors plan cancer surgery. PURPOSE: This laboratory study is looking at a new blood test to detect abnormal clotting in patients with metastatic cancer undergoing surgery. | |||
Clinicaltrials.gov | Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer | Withdrawn | Liver Cancer | Genetic, Genetic, Genetic, Genetic, Genetic, Other, Other, Other, Other - comparative genomic hybridization, molecular genetic technique, mutation analysis, polymerase chain reaction, proteomic profiling, immunohistochemistry staining method, laboratory biomarker analysis, mass spectrometry, medical chart review | Vanderbilt-Ingram Cancer Center, National Cancer Institute (NCI), Other, NIH | N/A - N/A | Observational | RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at biomarkers in stored tumor samples from younger patients with liver cancer. | |||
Clinicaltrials.gov | Studying DNA and Outcome in Patients With Advanced Colorectal Cancer Treated With Fluorouracil and Oxaliplatin With or Without Bevacizumab on Clinial Trial E-3200 | Completed | Colorectal Cancer | Genetic, Genetic, Genetic, Other - DNA methylation analysis, loss of heterozygosity analysis, microsatellite instability analysis, laboratory biomarker analysis | ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI), Other, NIH | 18 Years - 120 Years | Observational | RATIONALE: Studying samples of blood, urine, and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment. PURPOSE: This laboratory study is analyzing the DNA in tissue samples from patients with advanced colorectal cancer treated with fluorouracil and oxaliplatin with or without bevacizumab on clinical trial E-3200. | |||
Clinicaltrials.gov | Anti-tumor Immune Response in Patients With Cancer Undergoing Radiation Therapy | Recruiting | Malignant Neoplasm | Other, Other - cytology specimen collection procedure, laboratory biomarker analysis | Jonsson Comprehensive Cancer Center, Other | 18 Years - N/A | Observational | This research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response. | |||
Clinicaltrials.gov | Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer | Completed | Lung Cancer, Squamous Lung Dysplasia, Tobacco Use Disorder | Drug, Drug, Drug - deuterated phenanthrene tetraol, pharmacological study, laboratory biomarker analysis | University of Minnesota, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Observational | This clinical trial studies deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer. Studying samples of urine in the laboratory from smokers who are at high risk for lung cancer may help doctors learn more about biomarkers related to cancer. | |||
Clinicaltrials.gov | Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia | Unknown status | Leukemia | Genetic, Genetic, Genetic, Genetic, Genetic, Genetic, Genetic, Other - DNA analysis, fluorescence in situ hybridization, gene expression analysis, microarray analysis, mutation analysis, polymorphism analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis | Eastern Cooperative Oncology Group, National Cancer Institute (NCI), Other, NIH | 16 Years - 39 Years | Observational | RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This laboratory study is looking into genes in samples from younger patients with acute lymphoblastic leukemia (ALL). | |||
Clinicaltrials.gov | Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia | Completed | Leukemia | Genetic, Genetic, Other - RNA analysis, proteomic profiling, laboratory biomarker analysis | Children's Oncology Group, National Cancer Institute (NCI), Other, NIH | N/A - N/A | Observational | RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL). | |||
Clinicaltrials.gov | Biomarkers in Predicting Treatment Response in Samples From Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy | Not yet recruiting | Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer | Other, Other - medical chart review, laboratory biomarker analysis | National Cancer Institute (NCI), NIH | 18 Years - N/A | Observational | This research trial studies biomarkers in predicting treatment response in samples from patients with early-stage non-small cell lung cancer previously treated with adjuvant chemotherapy. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. | |||
Clinicaltrials.gov | Biomarker in Tissue Samples From Patients With Ewing Sarcoma | Completed | Sarcoma | Genetic, Genetic, Other, Other - microarray analysis, protein analysis, immunohistochemistry staining method, laboratory biomarker analysis | Children's Oncology Group, National Cancer Institute (NCI), Other, NIH | N/A - 120 Years | Observational | RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma. | |||
Clinicaltrials.gov | SWOG-8819 Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma | Completed | Lymphoma | Other, Other, Other - biologic sample preservation procedure, immunohistochemistry staining method, laboratory biomarker analysis | Southwest Oncology Group, National Cancer Institute (NCI), Other, NIH | 16 Years - N/A | Observational | RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. It may also help doctors learn how patients respond to treatment. PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from patients with non-Hodgkin's lymphoma. | |||
Clinicaltrials.gov | Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia | Active, not recruiting | Leukemia | Genetic, Genetic, Genetic, Genetic, Genetic, Genetic, Other, Other - DNA analysis, DNA methylation analysis, gene expression analysis, mutation analysis, polymerase chain reaction, reverse transcriptase-polymerase chain reaction, high performance liquid chromatography, laboratory biomarker analysis | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Other, NIH | N/A - N/A | Observational | RATIONALE: Studying samples of tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tissue and blood samples from patients with acute myeloid leukemia. | |||
Clinicaltrials.gov | S9031-S9126-S9333-S9500-A, Studying Bone Marrow and Blood Samples From Patients With Acute Myeloid Leukemia | Completed | Leukemia | Genetic, Genetic, Genetic, Genetic, Genetic, Other - DNA analysis, DNA methylation analysis, RNA analysis, gene expression analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis | Southwest Oncology Group, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Observational | RATIONALE: Studying samples of bone marrow and blood in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at bone marrow and blood samples from patients with acute myeloid leukemia. | |||
Clinicaltrials.gov | Immune Response in Peripheral Blood of Patients With Colon Cancer | Completed | Colorectal Cancer | Other, Other - immunoenzyme technique, laboratory biomarker analysis | University of Arizona, National Cancer Institute (NCI), Other, NIH | N/A - N/A | Observational | RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in the immune system that may help kill cancer cells. PURPOSE: This laboratory study is looking at anticancer immune responses in the peripheral blood of patients with colon cancer. | |||
Clinicaltrials.gov | DNA Analysis of Blood and/or Tissue Samples From Patients With Primary Kidney Cancer Receiving Sorafenib on Clinical Trial MRC-RE05-SORCE | Completed | Kidney Cancer | Genetic, Genetic, Genetic, Other, Other - mutation analysis, polymorphism analysis, protein expression analysis, immunohistochemistry staining method, laboratory biomarker analysis | Medical Research Council, Other | 18 Years - N/A | Observational | RATIONALE: Studying samples of blood and/or tissue in the laboratory from patients with kidney cancer receiving sorafenib may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to sorafenib. PURPOSE: This research study is looking at the DNA in blood and/or tissue samples from patients with primary kidney cancer receiving sorafenib on clinical trial MRC-RE05-SORCE. | |||
Clinicaltrials.gov | Biomarkers in Patients With Kidney Cancer or Cancer of the Urothelium and in Healthy Participants | Completed | Bladder Cancer, Kidney Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer | Other, Other, Other - immunologic technique, laboratory biomarker analysis, mass spectrometry | Wake Forest University Health Sciences, National Cancer Institute (NCI), Other, NIH | 18 Years - 120 Years | Observational | RATIONALE: Studying samples of blood and urine from patients with cancer and from healthy participants in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This laboratory study is looking at biomarkers in patients with kidney cancer or cancer of the urothelium and in healthy participants. |
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