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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.

(last updated: Nov 28, 2022)

Clinical Trials Information

285 Results - per page

DatabaseTitleRecruitmentConditionsInterventionSponsored ByGenderAge GroupsPhasesStudy TypeSummaryStart Date
Clinicaltrials.gov
Changes in Breast Density and Blood Hormone Levels in Postmenopausal Women Receiving Anastrozole or Exemestane for Breast CancerCompletedBreast CancerGenetic, Other, Other, Procedure - polymorphism analysis, high performance liquid chromatography, laboratory biomarker analysis, radiomammographyAlliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Other, NIHFemale18 Years - N/AObservationalRATIONALE: Studying changes in breast density and blood hormone levels in women receiving anastrozole or exemestane for breast cancer may help doctors learn more about the long-term effects of treatment and may help the study of breast cancer in the future. PURPOSE: This clinical trial is studying changes in breast density and blood hormone levels in postmenopausal women receiving anastrozole or exemestane for breast cancer.
Clinicaltrials.gov
Studying Genes for Barrett's Esophagus in Brothers and SistersUnknown statusEsophageal Cancer, Precancerous ConditionGenetic, Genetic, Other, Other, Procedure - comparative genomic hybridization, genetic linkage analysis, laboratory biomarker analysis, questionnaire administration, study of high risk factorsMedical Research Council, OtherN/A - N/AObservationalRATIONALE: Learning about how often heartburn and other risk factors occur in brothers and sisters and other family members of patients with Barrett's esophagus may help identify other individuals at risk and identify genes for Barrett's esophagus. PURPOSE: This clinical trial is studying genes for Barrett's esophagus in brothers and sisters.
Clinicaltrials.gov
Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation TherapyTerminatedBrain and Central Nervous System Tumors, ThrombocytopeniaDrug, Genetic, Genetic, Other, Other, Radiation - temozolomide, comparative genomic hybridization, polymorphism analysis, laboratory biomarker analysis, pharmacological study, radiation therapySidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Other, NIH18 Years - 120 YearsObservationalRATIONALE: Studying samples of blood in the laboratory from patients receiving temozolomide may help doctors learn how temozolomide works in the body. It may also help doctors learn more about how a patient's genes may affect the risk of developing thrombocytopenia. PURPOSE: This clinical trial is studying the pharmacokinetics in patients with newly diagnosed high-grade glioma receiving temozolomide and radiation therapy.
Clinicaltrials.gov
Depression and Interleukin-6 Production in Patients With Ovarian Epithelial CancerWithdrawnDepression, Fatigue, Ovarian Cancer, Psychosocial Effects of Cancer and Its Treatment, Sleep DisordersGenetic, Other, Other, Other, Procedure, Procedure, Procedure - polymorphism analysis, laboratory biomarker analysis, physiologic testing, questionnaire administration, conventional surgery, fatigue assessment and management, psychosocial assessment and careJonsson Comprehensive Cancer Center, National Cancer Institute (NCI), Other, NIHFemale18 Years - 55 YearsObservationalRATIONALE: Measuring levels of interleukin-6 and depression may help doctors understand the relationship between interleukin-6 and depression. It may also help the study of cancer in the future. PURPOSE: This clinical trial is studying depression and interleukin-6 production in patients with ovarian epithelial cancer.
Clinicaltrials.gov
Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary MelanomaUnknown statusHereditary Multiple Melanoma, Melanoma (Skin)Genetic, Genetic, Genetic, Genetic, Other, Procedure, Procedure - gene expression analysis, microarray analysis, molecular genetic technique, mutation analysis, laboratory biomarker analysis, mutation carrier screening, study of high risk factorsLeeds Cancer Centre at St. James's University Hospital, OtherN/A - N/AObservationalRATIONALE: Identifying gene mutations and other risk factors in patients with melanoma and in families with a history of hereditary melanoma may help doctors identify persons at risk for melanoma and other types of cancer. It may also help the study of cancer in the future. PURPOSE: This clinical trial is studying gene mutations in patients with melanoma and in families with a history of hereditary melanoma.
Clinicaltrials.gov
Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing SurgeryCompletedThromboembolism, Unspecified Adult Solid Tumor, Protocol SpecificOther, Other, Other, Other, Procedure - coagulation study, immunoenzyme technique, laboratory biomarker analysis, physiologic testing, study of high risk factorsNational Cancer Institute (NCI), NIH18 Years - N/AObservationalRATIONALE: A test that detects abnormal blood clotting in patients with cancer may help doctors plan cancer surgery. PURPOSE: This laboratory study is looking at a new blood test to detect abnormal clotting in patients with metastatic cancer undergoing surgery.
Clinicaltrials.gov
Biomarkers in Stored Tumor Samples From Younger Patients With Liver CancerWithdrawnLiver CancerGenetic, Genetic, Genetic, Genetic, Genetic, Other, Other, Other, Other - comparative genomic hybridization, molecular genetic technique, mutation analysis, polymerase chain reaction, proteomic profiling, immunohistochemistry staining method, laboratory biomarker analysis, mass spectrometry, medical chart reviewVanderbilt-Ingram Cancer Center, National Cancer Institute (NCI), Other, NIHN/A - N/AObservationalRATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at biomarkers in stored tumor samples from younger patients with liver cancer.
Clinicaltrials.gov
Studying DNA and Outcome in Patients With Advanced Colorectal Cancer Treated With Fluorouracil and Oxaliplatin With or Without Bevacizumab on Clinial Trial E-3200CompletedColorectal CancerGenetic, Genetic, Genetic, Other - DNA methylation analysis, loss of heterozygosity analysis, microsatellite instability analysis, laboratory biomarker analysisECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI), Other, NIH18 Years - 120 YearsObservationalRATIONALE: Studying samples of blood, urine, and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment. PURPOSE: This laboratory study is analyzing the DNA in tissue samples from patients with advanced colorectal cancer treated with fluorouracil and oxaliplatin with or without bevacizumab on clinical trial E-3200.
Clinicaltrials.gov
Anti-tumor Immune Response in Patients With Cancer Undergoing Radiation TherapyRecruitingMalignant NeoplasmOther, Other - cytology specimen collection procedure, laboratory biomarker analysisJonsson Comprehensive Cancer Center, Other18 Years - N/AObservationalThis research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response.
Clinicaltrials.gov
Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung CancerCompletedLung Cancer, Squamous Lung Dysplasia, Tobacco Use DisorderDrug, Drug, Drug - deuterated phenanthrene tetraol, pharmacological study, laboratory biomarker analysisUniversity of Minnesota, National Cancer Institute (NCI), Other, NIH18 Years - N/AObservationalThis clinical trial studies deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer. Studying samples of urine in the laboratory from smokers who are at high risk for lung cancer may help doctors learn more about biomarkers related to cancer.
Clinicaltrials.gov
Studying Genes in Samples From Younger Patients With Acute Lymphoblastic LeukemiaUnknown statusLeukemiaGenetic, Genetic, Genetic, Genetic, Genetic, Genetic, Genetic, Other - DNA analysis, fluorescence in situ hybridization, gene expression analysis, microarray analysis, mutation analysis, polymorphism analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysisEastern Cooperative Oncology Group, National Cancer Institute (NCI), Other, NIH16 Years - 39 YearsObservationalRATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This laboratory study is looking into genes in samples from younger patients with acute lymphoblastic leukemia (ALL).
Clinicaltrials.gov
Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic LeukemiaCompletedLeukemiaGenetic, Genetic, Other - RNA analysis, proteomic profiling, laboratory biomarker analysisChildren's Oncology Group, National Cancer Institute (NCI), Other, NIHN/A - N/AObservationalRATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).
Clinicaltrials.gov
Biomarkers in Predicting Treatment Response in Samples From Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant ChemotherapyNot yet recruitingStage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung CancerOther, Other - medical chart review, laboratory biomarker analysisNational Cancer Institute (NCI), NIH18 Years - N/AObservationalThis research trial studies biomarkers in predicting treatment response in samples from patients with early-stage non-small cell lung cancer previously treated with adjuvant chemotherapy. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
Clinicaltrials.gov
Biomarker in Tissue Samples From Patients With Ewing SarcomaCompletedSarcomaGenetic, Genetic, Other, Other - microarray analysis, protein analysis, immunohistochemistry staining method, laboratory biomarker analysisChildren's Oncology Group, National Cancer Institute (NCI), Other, NIHN/A - 120 YearsObservationalRATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.
Clinicaltrials.gov
SWOG-8819 Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's LymphomaCompletedLymphomaOther, Other, Other - biologic sample preservation procedure, immunohistochemistry staining method, laboratory biomarker analysisSouthwest Oncology Group, National Cancer Institute (NCI), Other, NIH16 Years - N/AObservationalRATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. It may also help doctors learn how patients respond to treatment. PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from patients with non-Hodgkin's lymphoma.
Clinicaltrials.gov
Studying Tissue and Blood Samples From Patients With Acute Myeloid LeukemiaActive, not recruitingLeukemiaGenetic, Genetic, Genetic, Genetic, Genetic, Genetic, Other, Other - DNA analysis, DNA methylation analysis, gene expression analysis, mutation analysis, polymerase chain reaction, reverse transcriptase-polymerase chain reaction, high performance liquid chromatography, laboratory biomarker analysisAlliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Other, NIHN/A - N/AObservationalRATIONALE: Studying samples of tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tissue and blood samples from patients with acute myeloid leukemia.
Clinicaltrials.gov
S9031-S9126-S9333-S9500-A, Studying Bone Marrow and Blood Samples From Patients With Acute Myeloid LeukemiaCompletedLeukemiaGenetic, Genetic, Genetic, Genetic, Genetic, Other - DNA analysis, DNA methylation analysis, RNA analysis, gene expression analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysisSouthwest Oncology Group, National Cancer Institute (NCI), Other, NIH18 Years - N/AObservationalRATIONALE: Studying samples of bone marrow and blood in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at bone marrow and blood samples from patients with acute myeloid leukemia.
Clinicaltrials.gov
Immune Response in Peripheral Blood of Patients With Colon CancerCompletedColorectal CancerOther, Other - immunoenzyme technique, laboratory biomarker analysisUniversity of Arizona, National Cancer Institute (NCI), Other, NIHN/A - N/AObservationalRATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in the immune system that may help kill cancer cells. PURPOSE: This laboratory study is looking at anticancer immune responses in the peripheral blood of patients with colon cancer.
Clinicaltrials.gov
DNA Analysis of Blood and/or Tissue Samples From Patients With Primary Kidney Cancer Receiving Sorafenib on Clinical Trial MRC-RE05-SORCECompletedKidney CancerGenetic, Genetic, Genetic, Other, Other - mutation analysis, polymorphism analysis, protein expression analysis, immunohistochemistry staining method, laboratory biomarker analysisMedical Research Council, Other18 Years - N/AObservationalRATIONALE: Studying samples of blood and/or tissue in the laboratory from patients with kidney cancer receiving sorafenib may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to sorafenib. PURPOSE: This research study is looking at the DNA in blood and/or tissue samples from patients with primary kidney cancer receiving sorafenib on clinical trial MRC-RE05-SORCE.
Clinicaltrials.gov
Biomarkers in Patients With Kidney Cancer or Cancer of the Urothelium and in Healthy ParticipantsCompletedBladder Cancer, Kidney Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral CancerOther, Other, Other - immunologic technique, laboratory biomarker analysis, mass spectrometryWake Forest University Health Sciences, National Cancer Institute (NCI), Other, NIH18 Years - 120 YearsObservationalRATIONALE: Studying samples of blood and urine from patients with cancer and from healthy participants in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This laboratory study is looking at biomarkers in patients with kidney cancer or cancer of the urothelium and in healthy participants.
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