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RESEARCH RESOURCE IDENTIFIERS (RRIDs)
The Resource Identification Portal is not in the business of minting new identifiers. Whenever possible, the RRIDs it provides are based on existing identifiers from authoritative community databases and vendors for each resource type. To ensure their global uniqueness, RRIDs are prefixed to indicate the source of the identifier. For example, the "AB" prefix of the RRID AB_2140114 indicates its provision by the Antibody Registry. This source prefix also helps researchers find key metadata located in resource repositories, vendor catalogs, or aggregation services. To avoid ambiguity where a resource has been assigned more than one identifier by different authorities, such IDs are cross-referenced in our system. For example, the fgf8a(ti282a/+)AB zebrafish strain has the identifier ZDB-GENO-070209-1from the Zebrafish Information Network (ZFIN) model organism database, and ZL1030 from the Zebrafish International Resource Center (ZIRC) stock center. While our recommendations generally favor model organism communities such as ZFIN over supply centers such as ZIRC as the preferred sources of RRIDs, both are valid and used in the literature, and can be resolved to a single resource in our system.
RESEARCH RESOURCE CITATION GUIDELINES
RRIDs are provided in this portal as part of research resource citations (RRCs), which are pre-formatted snippets of text that can be copied directly into a publication. RRCs are comprised of an RRID plus additional metadata that is recommended to be included when citing a resource. The structure and content of these RRCs represent a standard for how resources should be cited in the literature to adequately document their identity and provenance. Below we review the key elements of research resource citations for antibodies, tools, and organisms, and the key attributes of these resources types that are critical to cite for their identification and re-use.
Commercial antibody RRCs provided here include a vendor name, catalog number, and an RRID that is derived from the Antibody Registry (ABR) authority:
Abgent Cat# AP7251E, RRID:AB_2140114
While a vendor and catalog number may be a sufficient for uniquely identifying most antibodies, an Antibody Registry identifier is useful in virtue of how antibodies are cataloged and distributed across vendors - which often results in a single antibody becoming associated with numerous catalog numbers. The Antibody Registry associates each unique antibody with a registry identifier that tracks with this reagent throughout its lifetime, no matter how its catalog number or vendor may change.
Lab-Sourced antibodies are also a target for inclusion in the registry, but we depend largely on users like you to register them. An submission portal currently resides here for any antibody (commercial or lab-sourced) not found in the registry database, which will return an identifier for immediate use. But in cases where antibodies need to be cited without an identifier, authors should provide sufficient protocol details to allow its reproduction. This minimally includes specifying the host organism, recognized targets, and the immunogen used in its production. For peptide immunogens, the sequence should be reported in full, or a unique identifier or pointer resolving to single gene product should be provided (including start/end coordinates against this reference sequence when only a portion of a protein sequence is used).
Software tool and database citations provided here include a standard tool name, the provider, a version number if available, and RRID based on a NIF SciCrunch Registry identifier:
CellProfiler Image Analysis Software, V2.0, RRID:nif-0000-00280
At present the recognized authority for software tools is the NIF SciCrunch Registry, which focuses largely on non-commercial tools, but as our content expands new sources of tools will be included. When a single tool is referenced with different identifiers in different sources, they will be cross-referenced in our system. A recommended name and the providing organization is also included in the RRC. This offers important provenance information which can be relevant for obtaining the resource, and for documenting any code modifications at in a particular implementation. Any tools that are not found in the Resource Identification Portal should be registered with the NIF SciCrunch Registry as a "General Resource" here, and an identifier will be supplied for use in your publication.
At present, the citation provided for organisms includes only an RRID that is derived from a model organism database authority:
If the organism was obtained from a supplier, the vendor and stock number should also be provided.
As noted above, when a single organism is referenced with different identifiers in different sources (e.g. ZFIN and ZIRC), they will be cross-referenced in our system. We leave it up to authors to document the organism name in their citation, as the names in this portal are not yet stable, and authors often prefer their own syntax or notations to be used in a publication. Our recommendation is for names of genetically modified organisms to specify their genotype according to nomenclature guidelines of each model organism authority listed below. Organisms that are not found in this portal or in their respective MOD should be registered with the proper authority, most of which will return an identifier within 24 hours. When necessary, citations reporting organisms in the absence of an identifier should include all known genotype-related information. This includes the genetic background and breeding history, as well as the sequence, genomic location, and zygosity of alterations and transgenic insertions.
Organism Authorities, Submission
The following model organism authorities provide identifiers used in constructing organism RRIDs.
To submit or name a new organism resource, follow the relevant submission and nomenclature links below.
Single Celled Organisms
Additional Model Organism Authorities
Amoebae (D. discoideum): Dictybase Homepage
Chicken(Gallus gallus): Trans-NIH Gallus Initiative Homepage
Fission Yeast (S.pombe): Trans-NIH S. Pombe Initiative Homepage
Filamentous fungus (Neurospora): Trans-NIH Neurospora Initiative Homepage
Daphnia: Trans-NIH Daphnia Initiative Homepage
The following bioresource centers distribute authenticated cell lines, following the ANSI standard for human cell line authentication.