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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer | Active, not recruiting | BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer | Dietary Supplement, Other, Other, Procedure, Procedure, Other, Other, Procedure - soy isoflavones, placebo, questionnaire administration, magnetic resonance imaging, biopsy, immunohistochemistry staining method, laboratory biomarker analysis, mammography | University of Southern California, National Cancer Institute (NCI), California Breast Cancer Research Program, Other, NIH, Other | Female | 30 Years - 75 Years | N/A | Interventional | RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of soy isoflavones supplements may prevent or treat early stage breast cancer. PURPOSE: This clinical trial studies soy isoflavones supplementation in treating women at high risk for or with breast cancer. | |
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Clinicaltrials.gov | Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early Stage Peripheral Non-small Cell Lung Cancer | Withdrawn | Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer | Radiation, Procedure, Other, Other - stereotactic radiosurgery, therapeutic conventional surgery, laboratory biomarker analysis, quality-of-life assessment | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | N/A | Interventional | This pilot clinical trial studies the side effects and how well stereotactic radiosurgery followed by wedge resection works in treating patients with early stage non-small cell lung cancer that is located in the outer, or peripheral, areas of the lung. Stereotactic radiosurgery, also known as stereotactic body radiation therapy, is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Wedge resection is a less invasive type of surgery for removal of the tumor and a small amount of normal tissue around it. Giving stereotactic radiosurgery followed by wedge resection may be a safe treatment option for patients who cannot receive standard treatment with lobectomy. | ||
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Clinicaltrials.gov | Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients With Atypical Endometrial Hyperplasia or Endometrial Cancer | Withdrawn | Atypical Endometrial Hyperplasia, Endometrial Adenocarcinoma, Recurrent Endometrial Carcinoma, Stage IA Endometrial Carcinoma, Stage IB Endometrial Carcinoma, Stage II Endometrial Carcinoma, Stage IIIA Endometrial Carcinoma, Stage IIIB Endometrial Carcinoma, Stage IIIC Endometrial Carcinoma, Stage IVA Endometrial Carcinoma, Stage IVB Endometrial Carcinoma | Drug, Device, Other, Other - megestrol acetate, levonorgestrel-releasing intrauterine system, laboratory biomarker analysis, questionnaire administration | University of Southern California, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - 44 Years | Phase 2 | Interventional | This randomized phase II trial studies how well megestrol acetate or levonorgestrel-releasing intrauterine system works in treating patients with atypical endometrial hyperplasia or endometrial cancer. Progesterone can cause the growth of endometrial cancer cells. Hormone therapy using megestrol acetate or levonorgestrel-releasing intrauterine system may fight endometrial cancer by lowering the amount of progesterone the body makes. It is not yet known whether megestrol acetate is more effective than levonorgestrel-releasing intrauterine system in treating atypical endometrial hyperplasia or endometrial cancer. | |
Clinicaltrials.gov | Oxaliplatin and Pemetrexed Disodium in Treating Patients With Refractory Hormone-Resistant Prostate Cancer | Completed | Hormone-resistant Prostate Cancer, Recurrent Prostate Cancer | Drug, Drug, Other, Other, Genetic, Genetic - oxaliplatin, pemetrexed disodium, questionnaire administration, laboratory biomarker analysis, reverse transcriptase-polymerase chain reaction, polymorphism analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | Male | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies how well giving oxaliplatin and pemetrexed disodium together works in treating patients with refractory hormone-resistant prostate cancer. Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving oxaliplatin together with pemetrexed disodium may kill more tumor cells. | |
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Clinicaltrials.gov | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy | Terminated | Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer | Drug, Drug, Drug, Procedure, Genetic, Genetic, Other, Genetic, Genetic, Genetic - panobinostat, fluorouracil, leucovorin calcium, biopsy, reverse transcriptase-polymerase chain reaction, western blotting, laboratory biomarker analysis, gene expression analysis, RNA analysis, polymorphism analysis | University of Southern California, Novartis, Other, Industry | 18 Years - N/A | Phase 1 | Interventional | Panobinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fluorouracil and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving panobinostat together with fluorouracil and leucovorin calcium may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and the best dose of giving panobinostat, fluorouracil, and leucovorin calcium together in treating patients with stage IV colorectal cancer who did not respond to previous fluorouracil-based chemotherapy. | ||
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Clinicaltrials.gov | Regorafenib in Treating Patients With Advanced or Metastatic Neuroendocrine Tumors | Completed | Gastrinoma, Glucagonoma, Insulinoma, Metastatic Gastrointestinal Carcinoid Tumor, Pancreatic Polypeptide Tumor, Pulmonary Carcinoid Tumor, Recurrent Gastrointestinal Carcinoid Tumor, Recurrent Islet Cell Carcinoma, Somatostatinoma | Drug, Other - regorafenib, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies regorafenib in treating patients with neuroendocrine tumors that have spread from the primary site (place where it started) to other places in the body. Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. | ||
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Clinicaltrials.gov | Molecular Signatures of Relapse in Tissue Samples From Patients With Small Cell Lung Cancer Who Are Receiving Cisplatin and Etoposide | Withdrawn | Small Cell Lung Cancer | Other, Other - cytology specimen collection procedure, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Observational | This pilot research trial studies molecular signatures of the return of cancer after a period of improvement (relapse) in tissue samples from patients with small cell lung cancer who are receiving or planning to receive cisplatin and etoposide. Studying samples of tissue from patients with small cell lung cancer in the laboratory may help doctors learn more about the changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer relapse. | |||
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Clinicaltrials.gov | Diffusion-Weighted MRI in Staging Patients With Localized Prostate Cancer | Completed | Adenocarcinoma of the Prostate, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer | Procedure, Other - diffusion-weighted magnetic resonance imaging, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | Male | 18 Years - N/A | N/A | Interventional | This pilot clinical trial studies how well diffusion-weighted magnetic resonance imaging (MRI) works in staging patients with prostate cancer that has not spread to nearby lymph nodes or other parts of the body. New imaging techniques, such as diffusion-weighted MRI, may be a less invasive way of predicting the stage and grade of prostate cancer. | |
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Clinicaltrials.gov | Phenelzine Sulfate in Treating Patients With Non-metastatic Recurrent Prostate Cancer | Active, not recruiting | Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer | Drug, Other, Other - phenelzine sulfate, laboratory biomarker analysis, questionnaire administration | University of Southern California, National Cancer Institute (NCI), Other, NIH | Male | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies phenelzine sulfate in treating patients with prostate cancer that has not spread to other parts of the body and has come back. Phenelzine sulfate is a type of antidepressant that works by decreasing the amount of a protein called monoamine oxidase (MAO). MAO drugs may have an anticancer effect in prostate cancer. | |
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Clinicaltrials.gov | Fosaprepitant Dimeglumine and Granisetron Transdermal System in Preventing Nausea and Vomiting in Patients With Breast Cancer Undergoing Chemotherapy | Terminated | Breast Cancer, Nausea, Vomiting | Drug, Drug, Other - granisetron transdermal system, fosaprepitant dimeglumine, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Phase 1 | Interventional | This clinical trial studies how well fosaprepitant dimeglumine and granisetron transdermal system work in preventing nausea and vomiting in patients with breast cancer undergoing chemotherapy. Antiemetic drugs may help lessen or prevent nausea and vomiting in patients treated with chemotherapy | ||
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Clinicaltrials.gov | Docetaxel and Lapatinib in Metastatic Transitional Cell Carcinoma in Bladder | Terminated | Recurrent Bladder Cancer, Stage III Bladder Cancer, Stage IV Bladder Cancer, Transitional Cell Carcinoma of the Bladder | Drug, Drug, Other, Genetic, Other - docetaxel, lapatinib ditosylate, immunohistochemistry staining method, fluorescence in situ hybridization, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), GlaxoSmithKline, Other, NIH, Industry | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies how well giving docetaxel and lapatinib ditosylate together as second-line therapy works in treating patients with stage IV bladder cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Lapatinib ditosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving docetaxel and lapatinib ditosylate together may kill more tumor cells. | ||
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Clinicaltrials.gov | Comprehensive Genomic Analysis in Tissue and Blood Samples From Young Patients With Lung Cancer | Completed | Non-small Cell Lung Cancer, Small Cell Lung Cancer | Other, Other - cytology specimen collection procedure, laboratory biomarker analysis | University of Southern California, Foundation Medicine, Addario Lung Cancer Medical Institute, National Cancer Institute (NCI), Other, Industry, Other, NIH | N/A - 39 Years | Observational | This research trial studies genomic analysis in tissue and blood samples from young patients with lung cancer. Identifying specific gene mutations (changes in deoxyribonucleic acid [DNA]) may help doctors tailor treatment to target the specific mutations and help plan effective treatment. | |||
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Clinicaltrials.gov | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer | Withdrawn | Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Rectum, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer | Biological, Drug, Drug, Other - ziv-aflibercept, leucovorin calcium, fluorouracil, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies how long it takes colorectal cancer resistant to standard treatment to grow while receiving treatment with ziv-aflibercept, and how well adding fluorouracil and leucovorin calcium to ziv-aflibercept works in treating patients with stage IV colorectal cancer after they progress on ziv-aflibercept alone. Ziv-aflibercept may stop the growth of colorectal cancer by blocking the formation of tumor blood vessels. Fluorouracil and leucovorin calcium are drugs used in chemotherapy. Fluorouracil works to stop the growth of tumors cells by preventing the cells from growing and dividing. Leucovorin calcium helps fluorouracil work better. Adding fluorouracil and leucovorin calcium to ziv-aflibercept may be an effective treatment for patients who progress on ziv-aflibercept alone. | ||
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Clinicaltrials.gov | Vaccine Therapy in Treating Patients With Stage IIC-IV Melanoma | Completed | Ciliary Body and Choroid Melanoma, Medium/Large Size, Ciliary Body and Choroid Melanoma, Small Size, Extraocular Extension Melanoma, Iris Melanoma, Metastatic Intraocular Melanoma, Mucosal Melanoma, Recurrent Intraocular Melanoma, Recurrent Melanoma, Stage IIC Melanoma, Stage IIIA Intraocular Melanoma, Stage IIIA Melanoma, Stage IIIB Intraocular Melanoma, Stage IIIB Melanoma, Stage IIIC Intraocular Melanoma, Stage IIIC Melanoma, Stage IV Intraocular Melanoma, Stage IV Melanoma | Biological, Biological, Biological, Biological, Biological, Drug, Drug, Other - gp100 antigen, tyrosinase peptide, recombinant MAGE-3.1 antigen, multi-epitope melanoma peptide vaccine, incomplete Freund's adjuvant, Montanide ISA 51 VG, agatolimod sodium, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 16 Years - N/A | Phase 2 | Interventional | This pilot phase II trial studies how well giving vaccine therapy works in treating patients with stage IIC-IV melanoma. Vaccines made from melanoma peptides or antigens may help the body build an effective immune response to kill tumor cells | ||
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Clinicaltrials.gov | Resistance Training and Protein Supplementation for Prostate Cancer Survivors | Completed | Prostate Cancer | Behavioral, Dietary Supplement, Procedure, Other, Other, Other - exercise intervention, nutritional supplementation, quality-of-life assessment, questionnaire administration, pharmacological study, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | Male | 50 Years - N/A | N/A | Interventional | This randomized pilot clinical trial studies resistance training and protein supplementation in increasing lean body mass in patients with prostate cancer receiving androgen deprivation therapy. Resistance training and protein supplementation may help improve quality of life in patients with prostate cancer receiving androgen deprivation therapy. | |
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Clinicaltrials.gov | Capecitabine, Cyclophosphamide, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With HER2-Positive Metastatic Breast Cancer | Terminated | HER2-positive Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer | Drug, Drug, Drug, Biological, Other - capecitabine, cyclophosphamide, lapatinib ditosylate, trastuzumab, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies how well capecitabine, cyclophosphamide, lapatinib ditosylate, and trastuzumab work in treating patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. Drugs used in chemotherapy, such as capecitabine and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving capecitabine and cyclophosphamide daily may kill more tumor cells. Lapatinib ditosylate may stop the growth of tumor cells by blocking some of the enzymes needed for growth. Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of the tumor to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving capecitabine, cyclophosphamide, lapatinib ditosylate, and trastuzumab together may be an effective treatment for breast cancer. | |
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Clinicaltrials.gov | Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia | Terminated | Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloblastic Leukemia With Maturation (M2), Adult Acute Myeloblastic Leukemia Without Maturation (M1), Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13, q22), Adult Acute Myeloid Leukemia With t(16, 16)(p13, q22), Adult Acute Myeloid Leukemia With t(8, 21)(q22, q22), Adult Acute Myelomonocytic Leukemia (M4), Adult Erythroleukemia (M6a), Adult Pure Erythroid Leukemia (M6b), Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7), Childhood Acute Monoblastic Leukemia (M5a), Childhood Acute Monocytic Leukemia (M5b), Childhood Acute Myeloblastic Leukemia With Maturation (M2), Childhood Acute Myeloblastic Leukemia Without Maturation (M1), Childhood Acute Myeloid Leukemia in Remission, Childhood Acute Myelomonocytic Leukemia (M4), Recurrent Adult Acute Myeloid Leukemia, Recurrent Childhood Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Untreated Adult Acute Myeloid Leukemia, Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies | Drug, Drug, Procedure, Other - mitoxantrone hydrochloride, cytarabine, peripheral blood stem cell transplantation, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | N/A - N/A | Phase 1 | Interventional | This phase I trial studies the side effects of donor stem cell transplant in treating patients with high risk acute myeloid leukemia. Giving low doses of chemotherapy before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells when they do not exactly match the patient's blood. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect) | ||
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Clinicaltrials.gov | Vorinostat Before Surgery in Treating Patients With Triple-Negative Breast Cancer | Withdrawn | Stage II Breast Cancer, Stage IIIA Breast Cancer, Triple-negative Breast Cancer | Drug, Procedure, Other - vorinostat, therapeutic conventional surgery, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - N/A | N/A | Interventional | This pilot clinical trial studies vorinostat before surgery in treating patients with triple-negative breast cancer. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving enzyme inhibitor therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed | |
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Clinicaltrials.gov | Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery | Withdrawn | Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Triple-negative Breast Cancer | Drug, Other, Other, Genetic, Genetic, Genetic, Procedure - azacitidine, laboratory biomarker analysis, immunohistochemistry staining method, polymerase chain reaction, western blotting, nucleic acid sequencing, therapeutic conventional surgery | University of Southern California, National Cancer Institute (NCI), Other, NIH | Female | 18 Years - N/A | N/A | Interventional | This clinical trial studies azacitidine in treating patients with triple negative stage I-IV invasive breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. | |
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Clinicaltrials.gov | Mindfulness-Based Exercise Video in Educating Hispanic/Latino Patients With Colorectal Cancer and Their Caregivers | Terminated | Anxiety Disorder, Colon Cancer, Depression, Fatigue, Rectal Cancer | Other, Procedure, Other, Other, Other - educational intervention, CAM exercise therapy, caregiver-related intervention or procedure, questionnaire administration, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Other, NIH | 18 Years - 65 Years | N/A | Interventional | This randomized pilot trial studies mindfulness-based program in educating patients with colorectal cancer and their caregivers. A mindfulness-based exercise video may help reduce stress and fatigue in patients with colorectal cancer and their caregivers. |
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