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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Beta-Blocker Evaluation in Survival Trial (BEST) | Completed | Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive, Heart Failure | Drug - adrenergic beta antagonists | National Heart, Lung, and Blood Institute (NHLBI), NIH | 18 Years - 100 Years | Phase 3 | Interventional | To determine if addition of a beta-blocker to standard therapy in Class III and Class IV heart failure patients reduced total mortality. | ||
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Clinicaltrials.gov | The Cascade Feasibility Pilot (HF) Phase 3 | Recruiting | Heart Failure | Other, Other - Non-invasive continuous remote monitoring with structured escalation pathway, Affective Analysis of Participant Response to Continuous Remote Patient Monitoring | NorthShore University HealthSystem, Other | 18 Years - 100 Years | N/A | Interventional | The study proposal is to deploy a wearable solution that predicts physiological perturbation comparable to invasive devices and to perform continuous remote patient monitoring; this will be connected to a structured, cascading, escalation pathway involving home health nurses, advanced practitioner providers, and heart failure specialists, and has the potential to transform heart failure management in the post-discharge period, where patients are the most vulnerable for readmission. This feasibility study will contribute to the understanding of post-discharge heart failure continuous remote patient monitoring, promote patient self-care, and has the potential of improving patient outcomes. | ||
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Clinicaltrials.gov | Clinical Study of LBBP | Recruiting | Bradyarrhythmias, Heart Failure | Procedure - pacemaker implantation | Second Affiliated Hospital, School of Medicine, Zhejiang University, Other | 18 Years - 100 Years | Observational | At present, cardiac pacing has been widely used in the treatment of bradyarrhythmias and heart failure, which can effectively improve the survival rate of patients. With the rapid development of technology, you can choose to pace the heart in different parts. The atrium can choose the right atrial appendage, the atrial septum and the right ventricular side wall. The right ventricle can choose to be paced in the His bundle, right ventricular apex and ventricular septal outflow tract. The right ventricle can choose the pacing positions including left bundle branch pacing and left ventricular pacing via coronary vein. There are few studies comparing the long-term efficacy and safety of different pacing programs in daily practice. This study is to observe the short-term and long-term effects and safety of different parts of cardiac pacing, and compare the advantages and disadvantages of different parts of cardiac pacing. | |||
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Clinicaltrials.gov | Registry Of Acute meDical Emergencies in Brazil | Unknown status | Acute Coronary Syndromes, Heart Failure, Pulmonary Edema, Aortic Aneurysm, Familial Thoracic 1, Chest Pain, Pulmonary Embolism, Syncope | Other - no intervention | University of Sao Paulo General Hospital, Other | 18 Years - 100 Years | Observational [Patient Registry] | Critical patients in emergency room are seriously situations that need quickly diagnosis and treatment. Different predictors of prognosis can be related with mortality and morbidity in-hospital and in long-term. In Brazil, this kind of registry is not available. The aim of the study is analysis and report data about critical patients in Emergency Departments over all country, showing demographic, clinical and prognosis data about that in Brazil. | |||
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Clinicaltrials.gov | Handheld Ultrasound at Remote Locations | Completed | Heart Failure | Diagnostic Test - Focused ultrasound diagnostics | Helse Nord-Trøndelag HF, Norwegian University of Science and Technology, Levanger and Verdal Muncipality, Other, Other, Other | 18 Years - 100 Years | N/A | Interventional | Heart failure causes a large patient and financial burden on the health care system. Pocket ultrasound imaging devices are utilized to improve time to correct diagnosis. Telemedicine is used in a variety of medical professions today. A combination of focused handheld ultrasound imaging performed by general practitioners and dedicated nurses in a heart failure population, utilizing telemedicine for support, has not yet been studied. The aim of the study is to evaluate the feasibility, reliability and clinical influence of implementing handheld focused cardiac ultrasound by general practitioners and nurses for diagnostics and health-related expenditure in outpatients referred with suspected heart failure. | ||
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Clinicaltrials.gov | Biodex Sit2Stand for Individuals With Cardiac Disease | Withdrawn | Coronary Artery Disease, Frail Elderly Syndrome, Heart Failure | Behavioral - Exercise using the Biodex Sit2Stand Trainer | St. Ambrose University, Other | 18 Years - 100 Years | N/A | Interventional | Patients with cardiac disease have been shown to have deficits in activities such as standing up from a chair. The Biodex Sit2Stand Trainer is a new device meant to improve sit to stand performance by providing a lifting force through the seat to help the individual stand. The amount of lift can be graded to help improve leg strength, endurance, and function over time. The device has the potential to be a form of training for those in cardiac rehabilitation who have limitations in standing from a chair. | ||
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Clinicaltrials.gov | Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction Patients: a Real World Study in India | Active, not recruiting | Heart Failure | Drug - sacubitril/valsartan | Novartis Pharmaceuticals, Industry | 18 Years - 100 Years | Observational | This will be a non-interventional, retrospective EMR analysis of longitudinal prescriptions in India for a period of 1.5 years. Demographic profile of patients with heart failure with reduced ejection fraction on sacubitril/valsartan will be recorded. | |||
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Clinicaltrials.gov | The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement | Recruiting | Aortic Valve Stenosis, Heart Failure, Inotropic Agents, Safety Issues, Effect of Drug, Cardiac Event, Transcatheter Aortic Valve Replacement | Drug, Other - Levosimendan, Placebo | China National Center for Cardiovascular Diseases, China International Medical Foundation, Other, Other | 18 Years - 100 Years | Phase 4 | Interventional | A study to evaluate the effectiveness and safety of levosimendan compared with placebo in subjects with severe aortic stenosis and heart failure undergoing transcatheter aortic valve replacement | ||
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Clinicaltrials.gov | Mechanisms and Innovations in Cardiac Resynchronisation Therapy | Recruiting | Heart Failure, Left Ventricular Systolic Dysfunction, Left Bundle-Branch Block, Right Bundle-Branch Block, Non-Specific Intraventricular Conduction Defect | Device - His-bundle pacing. | Imperial College London, Other | 18 Years - 100 Years | N/A | Interventional | The aim of this study is to compare the effectiveness of multiple modalities of cardiac resynchronisation therapy using high precision acute electrical and haemodynamic measurements.These modalities include biventricular pacing and conduction system pacing utilising His bundle and left bundle pacing. Conduction system pacing is a more physiological form of pacing. The study hypothesises that this will produce more effective cardiac resynchronisation. | ||
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Clinicaltrials.gov | Effect of Levosimendan or Placebo on Exercise in Advanced Chronic Heart Failure | Unknown status | Heart Failure | Drug, Drug - Levosimendan, Placebo | Finn Gustafsson, Orion Corporation, Orion Pharma, Other, Industry | 18 Years - 100 Years | Phase 4 | Interventional | Purpose: This study evaluates the subacute effect of levosimendan infusion on exercise capacity and exercise hemodynamics compared with placebo in patients with advanced chronic heart failure. Hypothesis: Treatment with 6 hours infusion of levosimendan compared with placebo improves exercise capacity and exercise hemodynamics evaluated by change in CO/PCWP. Design: The study is a prospective multi-center, double-blinded, placebo controlled randomized study. 42 consecutive patients who meet the eligibility criteria will be enrolled. | ||
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Clinicaltrials.gov | Cardiac Contractility Modulation Therapy in Amyloid Cardiomyopathy Patients With Heart Failure | Recruiting | Amyloidosis Cardiac, Heart Failure | Device - Cardiac Contractility Modulation (CCM) | Ospedale C & G Mazzoni, Other | 18 Years - 100 Years | Observational | The primary aim of this observational registry is to evaluate the efficacy of CCM in patients with heart failure with mid-range or reduced EF and diagnosis of TTR amyloidosis. The efficacy will be evaluated in terms of composite of occurrence of heart failure-related hospitalizations and/or acute intravenous interventions (IVI) at 12-month follow up compared to those reported 12 months before CCM implantation. Among the secondary endpoints, clinical functional status, quality of life, drug changes and Echocardiographic parameters will be evaluated and compared from baseline to follow up. | |||
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Clinicaltrials.gov | Fluoroscopy Reduction or Elimination in CIED Implants | Recruiting | Bradycardia, Tachycardia, Ventricular, Heart Failure | Device - Fluoroscopy reduction | Université de Sherbrooke, Other | 18 Years - 100 Years | N/A | Interventional | CIED implants require different amounts of fluoroscopy; using 3-D mapping systems, these times could be reduced to near zero fluoroscopy. The investigators aim to describe to what extent fluoroscopy times are reduced on a routine basis on CIED implants | ||
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Clinicaltrials.gov | Clinical Study of Impact of Different Pacing Site in Patients | Recruiting | Bradyarrhythmias, Heart Failure, Pacemaker | Device - Pacemaker implantation | Second Affiliated Hospital, School of Medicine, Zhejiang University, Other | 18 Years - 100 Years | Observational | At present, cardiac pacing has been widely used in the treatment of bradyarrhythmias and heart failure, which can effectively improve the survival rate of patients. With the rapid development of technology, different sites can be chosen to pace, such as right atrial appendage, the atrial septum and the right atrial wall in the atrium, His bundle, left bundle branch area, right ventricular apex, outflow tract, and left ventricular pacing via coronary vein in the ventricle. There are few studies comparing the long-term efficacy and safety of different pacing sites in daily practice. This study aims to observe the efficacy and safety of cardiac pacing at different sites in short and long term, and to compare the advantages and disadvantages of pacing at different sites. | |||
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Clinicaltrials.gov | Breathing Exercise Against Dyspnoea in Heart Failure Patients to Improve Chemosensitivity | Not yet recruiting | Heart Failure | Behavioral - Breathing training | University Hospital Inselspital, Berne, Other | 18 Years - 100 Years | N/A | Interventional | An exaggerated ventilatory response (minute ventilation, V̇E) to exercise relative to exhaled carbon dioxide (V̇CO2) is common in heart failure (HF) patients with reduced as well as preserved left ventricular ejection fraction (HFrEF, HFpEF). Severity of this exaggerated response is associated with poor prognosis. This response may be triggered by pulmonary congestion and peripheral muscle myopathy. A vicious circle is fuelled by hypersensitivity of chemoreceptors to hypercapnia and sympathetic nervous hyperactivity, resulting in hyperventilation (low PaCO2). Low PaCO2 is predictive of mortality in these patients. PaCO2 can be increased acutely, e.g. by apnoea. Also, nasal breathing has been found to reduce the V̇E/V̇CO2 slope during exercise compared to oral breathing. Three previous slow breathing studies in HFrEF patients have had encouraging results with regard to reducing sympathetic activity, reflected in lowered arterial (pulmonary) blood pressure and increased EF. The investigators hypothesise that a 12-week training with nasal slow breathing followed by end-expiratory apnoea based on education, centre-based introduction and home-based 15 min/day breathing training will be effective at reducing the exaggerated ventilatory response to exercise. A total of 68 patients with stable HF seen at the HF clinics of the Inselspital (34 HFrEF, 34 HFpEF) will be randomised to the breathing intervention or usual care. Primary outcome will be V̇E/V̇CO2 slope at 12 weeks. If breathing training successfully ameliorates the exaggerated ventilatory response and perception of dyspnea during exercise, it offers an attractive tele-health based add-on therapy that may add to or even amplify the beneficial effects of exercise training. | ||
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Clinicaltrials.gov | Outcomes of Patients With Heart Failure Hospitalized in an Internal Medicine Unit | Active, not recruiting | Heart Failure | University Hospital, Montpellier, Other | 18 Years - 100 Years | Observational | In 2018, the investigators evaluated the treatment of 236 patients with heart failure (with preserved or reduced ejection fraction) before and after hospitalization in our internal medicine unit (from 2016 to 2017). The investigators showed that patients, mainly elderly women with comorbidities, often had suboptimal heart failure treatment without an identified cause. The investigators tried, whenever possible, to optimize treatment before hospital discharge. Our objective is now to analyze the 4-year outcome of these patients, including re-hospitalization for heart failure or death. | ||||
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Clinicaltrials.gov | SELF - BREATHE for Chronic Breathlessness | Completed | COPD, Cancer, Heart Failure, Interstitial Disease, Dyspnea | Other - Qualitative research interviews to be conducted | King's College Hospital NHS Trust, King's College London, Other, Other | 18 Years - 100 Years | Observational | Semi-structured qualitative interviews will be conducted to understand key factors that would enable / facilitate patients with chronic breathlessness to potentially use an online breathlessness intervention (SELF-BREATHE). | |||
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Clinicaltrials.gov | Right Ventricular Function and Exercise Capacity in Patients With Continuous-flow Left Ventricular Assist Devices | Completed | Heart Failure | Other - Cardiac Computed tomography | Finn Gustafsson, Other | 18 Years - 100 Years | N/A | Interventional | Exercise capacity in continous-flow left ventricular assist device (CF-LVAD) patients remains severely reduced post-implant. While the effect of right ventricular (RV) failure early after pump implantation, and its effect on outcome has been extensively studied, the effects of late RV failure on exercise capacity and quality of life (QOL) has been sparsely described. Thus the purpose of this study is to examine RV function and the association to exercise capacity in CF-LVAD patients. | ||
Clinicaltrials.gov | ASIAN HF Registry, A Prospective Observational Study | Completed | Heart Failure | Genetic - Saliva Genetic testing | Carolyn Lam, Boston Scientific Corporation, Bayer, Translational & Clinical Research by NMRC Singapore, ATTRaCT program by A*STAR BMRC Singapore, Other, Industry, Industry, Other, Other | 18 Years - 100 Years | Observational | The ASIAN HF Registry is the first prospective multinational Asian registry of patients with symptomatic HF (stage C) including both HFrEF (ejection fraction <40%) and HFpEF (ejection fraction ≥50%), with the broad purpose of determining the mortality (incidence) burden of HF in Asian patients, and more specifically to define the burden and risk factors of Sudden Cardiac Deaths (SCD), as well as the sociocultural barriers to preventive device therapy. The study further aim to study the genetic variants associated with HFrEF versus HFpEF in our large Asian cohort. This proposed registry is expected to advance fundamental understanding of the burden and predictors of preventable death among Asian patients with HF. The knowledge gained will be critical for guiding resource allocation and planning preventive strategies to address the unmet and growing clinical needs of patients with cardiovascular disease in Asia. | |||
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Clinicaltrials.gov | Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics | Unknown status | Heart Failure | University of Alberta, Other | 18 Years - 100 Years | Observational | The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF. | ||||
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Clinicaltrials.gov | Pilot Testing of an Online Rehabilitation Intervention for People With Heart Failure (PORIAS-HF). | Recruiting | Heart Failure | Procedure, Procedure - Exercise, Self-managed exercise | Sheffield Hallam University, King's College London, Sheffield Teaching Hospitals NHS Foundation Trust, Other, Other, Other | 18 Years - 100 Years | N/A | Interventional | The inability of the heart to pump out blood to the rest of the body organs is called heart failure (HF). HF affects almost 920,000 people in the UK, costing the NHS up to £2.33bn/year. Physical exercise programmes aiming to improve the heart's ability to pump out blood are used to a) reduce the risk of life-threatening events (e.g., heart attack), b) reduce admissions to hospital and c) improve individual's physical independence (e.g., walking unsupported, being able toperform daily essential activities). However, these physical exercise programmes have been cut short under the current COVID-19 pandemic, with support in most UK regions being restricted to online videos and advice. With many people with HF being asked to be "shielded" or "self-isolate" for an unknown duration, it is important to develop a reliable and cost-effective physical exercise service to support this clinical group. The research team has developed a novel physical exercise programme, fully-delivered online. Before assessing if it could improve clinical outcomes (e.g., heart's ability to pump out blood) and how cost-effective it could be, a 10-month pilot study is proposed that will assess if the proposed online physical exercise programme could be performed in people with HF. Thirty participants will be allocated at random into two groups: Group A will receive up to 24 exercise sessions and up-to 3 lifestyle workshops, in addition to usual care over a 2-month period. Group B will receive a self-care exercise programme (≥3 sessions per week) for a two-month period in addition to usual care. Prior to the group random allocation, online assessments will be performed including demographics and clinical history, the ability to perform daily activities, sedentary or physical activity habits and quality of life. The assessments including interviews to assess participant's experiences will be repeated at 2 months |
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