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Snippet Table

TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6-SJLF1
Assessments: Conditioned fear testing, Morris Water Maze (MWM), Rotorod test, Histology, shock sensitivity testing
Citation: Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injuryJ Neurotrauma. 2007 Apr;24(4):657-73. doi: 10.1089\/neu.2006.0011. PMC2435168

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Array image analysis, Beam walk test, Cytokine array, Immunohistochemistry (IHC), Neurological Severity Score (NSS), confocal imaging, phospho-Akt array
Citation: Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F. Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injuryInt Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016\/j.intimp.2017.08.002. Epub 2017 Aug 12.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Beam walk test, Blood ethanol level, Confocal imaging, Neurological Severity Score (NSS), open field test, qRT-PCR, Western blot, histology
Citation: Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, Ludolph A, Huber-Lang M, Böckers T, Mauceri D, Knöll B, Roselli F. Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responsesExp Neurol. 2018 Apr;302:34-45. doi: 10.1016\/j.expneurol.2017.12.017. Epub 2018 Jan 4.

TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6-C3F1/J transgenic
Assessments: Amyloid burden, Astrocytic end feet contacts estimation, Capillary density estimation, Immunohistochemistry (IHC), Pericyte estimation, Histology
Citation: Clark AT, Abrahamson EE, Harper MM, Ikonomovic MD. Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosisFluids Barriers CNS. 2022 Jan 10;19(1):5. doi: 10.1186\/s12987-021-00301-z. PMC8751260

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The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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