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TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam balance test, Morris Water Maze (MWM), Beam walk test
Citation: Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL. A controlled cortical impact model of traumatic brain injury in the ratJ Neurosci Methods. 1991 Oct;39(3):253-62. doi: 10.1016\/0165-0270(91)90104-8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: PCR, Western blot
Citation: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in miceBrain Res. 2014 Oct 17;1585:13-22. doi: 10.1016\/j.brainres.2014.08.026. Epub 2014 Aug 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam walk test, open field test, Five serial choice reaction time task, time-to-right
Citation: Mychasiuk R, Hehar H, Esser MJ. A mild traumatic brain injury (mTBI) induces secondary attention-deficit hyperactivity disorder-like symptomology in young ratsBehav Brain Res. 2015 Jun 1;286:285-92. doi: 10.1016\/j.bbr.2015.03.010. Epub 2015 Mar 11.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Neurological Severity Score (NSS), RT-PCR
Citation: Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNeurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016\\/j.neulet.2014.10.037. Epub 2014 Oct 28.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay, Immunohistochemistry (IHC), Neurological function, RT-PCR, Western blot, Differential gene expression analysis
Citation: Xiong LL, Hu Y, Zhang P, Zhang Z, Li LH, Gao GD, Zhou XF, Wang TH. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated NeuroplasticityMol Neurobiol. 2018 Mar;55(3):2696-2711. doi: 10.1007\/s12035-017-0551-1. Epub 2017 Apr 18.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Morris Water Maze (MWM)
Citation: Adelson PD, Fellows-Mayle W, Kochanek PM, Dixon CE. Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature ratChilds Nerv Syst. 2013 Jan;29(1):43-53. doi: 10.1007\/s00381-012-1932-4. Epub 2012 Oct 23.
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Histology
Citation: Sindelar B, Bailes J, Sherman S, Finan J, Stone J, Lee J, Ahmadian S, Zhou Y, Patel V, Smith D. Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a Porcine Controlled Cortical Impact ModelJ Neurotrauma. 2017 Apr 15;34(8):1703-1709. doi: 10.1089\/neu.2016.4648. Epub 2016 Dec 16.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Western blot
Citation: Griesbach GS, Hovda DA, Gomez-Pinilla F, Sutton RL. Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in ratsNeuroscience. 2008 Jun 23;154(2):530-40. doi: 10.1016\/j.neuroscience.2008.04.003. Epub 2008 Apr 9. PMC2441485
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: RT-PCR
Citation: Sandhir R, Berman NE. Age-dependent response of CCAAT\/enhancer binding proteins following traumatic brain injury in miceNeurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016\/j.neuint.2009.10.002. Epub 2009 Oct 13. PMC2815015
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Zinc staining
Citation: Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW. Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrusJ Trace Elem Med Biol. 2014 Oct;28(4):474-81. doi: 10.1016\/j.jtemb.2014.07.007. Epub 2014 Aug 4.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Histology, Morris Water Maze (MWM)
Citation: Smith DH, Soares HD, Pierce JS, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effectsJ Neurotrauma. 1995 Apr;12(2):169-78. doi: 10.1089\/neu.1995.12.169.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Acoustic startle response, Body curl test, Elevated-plus maze, Forced swim test, Lesion volume, Morris Water Maze (MWM), open field test, prepulse inhibition
Citation: Washington PM, Forcelli PA, Wilkins T, Zapple DN, Parsadanian M, Burns MP. The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in miceJ Neurotrauma. 2012 Sep;29(13):2283-96. doi: 10.1089\/neu.2012.2456. Epub 2012 Aug 3. PMC3430487
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Amyloid precursor protein, Cortical contusion volume, Immunoglobulin, Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Neuroscore, Regional hippocampal neurodegeneration
Citation: Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studiesJ Neurotrauma. 2011 Nov;28(11):2245-62. doi: 10.1089\/neu.2010.1499. Epub 2011 Apr 21. PMC3218388
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay(ELISA), Immunohistochemistry (IHC), hippocampal neurogenesis, microglia response, radial arm water maze, Rotarod
Citation: Chen MM, Zhao GW, He P, Jiang ZL, Xi X, Xu SH, Ma DM, Wang Y, Li YC, Wang GH. Improvement in the neural stem cell proliferation in rats treated with modified \Shengyu\ decoction may contribute to the neurorestorationJ Ethnopharmacol. 2015 May 13;165:9-19. doi: 10.1016\/j.jep.2015.02.037. Epub 2015 Feb 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Morris Water Maze (MWM), Neurologic Deficit Scoring, Western Blot, Novel object recognition test, RT-PCR
Citation: Cheng T, Yang B, Li D, Ma S, Tian Y, Qu R, Zhang W, Zhang Y, Hu K, Guan F, Wang J. Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain InjuryCell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007\/s10571-015-0159-9. Epub 2015 Feb 1. PMC4481175
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459
TBI Model Type: Blast model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Immunohistochemistry (IHC)
Citation: Ahmed F, Gyorgy A, Kamnaksh A, Ling G, Tong L, Parks S, Agoston D. Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injuryElectrophoresis. 2012 Dec;33(24):3705-11. doi: 10.1002\/elps.201200299.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: 1H-MRS, Beam walk test, LC Model, Magnetic resonance imaging (MRI), Novel object recognition test, Open field exploratory
Citation: Singh K, Trivedi R, Haridas S, Manda K, Khushu S. Study of neurometabolic and behavioral alterations in rodent model of mild traumatic brain injury: a pilot studyNMR Biomed. 2016 Dec;29(12):1748-1758. doi: 10.1002\/nbm.3627. Epub 2016 Oct 25.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Lewis
Assessments: Immunohistochemistry (IHC)
Citation: Xu K, Yang Z, Shi R, Luo C, Zhang Z. Expression of aryl hydrocarbon receptor in rat brain lesions following traumatic brain injuryDiagn Pathol. 2016 Aug 9;11(1):72. doi: 10.1186\/s13000-016-0522-2. PMC4977631