We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Electrophysiology patch clamp amplifier for collecting electrical signals from tissues and cells. Can be controlled via USB. Designed and manufactured by HEKA Elektronik.
Core offers microscopy services. Provides three offline analysis systems with Intel Xeon-based processors. Two of these are custom-built Origin computers and the third is a Dell Precision computer. All analysis workstations have the most recent versions of the Fiji build of Image J and RStudio.
A classification of health and health-related domains. These domains are classified from body, individual and societal perspectives by means of two lists: a list of body functions and structure, and a list of domains of activity and participation. Since an individual''s functioning and disability occurs in a context, the ICF also includes a list of environmental factors.
Software R package for mapping quantitative trait loci with high dimensional data and multiparent populations. Used for analysis of high dimensional data and complex crosses. Interactive software environment for mapping quantitative trait loci in experimental populations.R/qtl2 software expands scope of R/qtl software package to include multiparent populations derived from more than two founder strains, such as Collaborative Cross and Diversity Outbred mice, heterogeneous stocks, and MAGIC plant populations.
Core for high resolution imaging and structural analysis of biological specimens, soft matter, and nanomaterials. Used to process samples from solution or powder, allowing researchers to visualize internal structures down to the subnanometer scale. It is critically important that the samples are non-magnetic.
A comprehensive ontology on primary and established cell lines-both normal and pathologic. It covers around 400 cell lines. This ontology has been built to include the major domains in the field of biology like anatomy, bio-molecules, chemicals and drugs, pathological conditions and genetic variations around the cell lines. An extensive network of relations has been built across these concepts to enable different combinations of queries. The ontology covers all cell lines from major sources like ATCC, DSMZ, ECACC, ICLC etc. and is built in OWL format.
The Gruss Lipper Precision Instrumentation Technologies (PIT) Resource Center provides access to various fabrication and rapid prototyping tools for qualified users. The PIT allows users to design and build their own research tools by providing access to wide array of prototyping and fabrication equipment, as well as design and fabrication consultation. The PIT also provides full prototyping service (design through fabrication and testing).
Core provides services in design, construction, and production of custom research grade viral vectors for biomedical research including Adeno-associated viral (AAV) vectors, Retroviral vectors (MLV-based), Lentiviral vectors (LV), Virus-Like Particles (VLPs / Nanoblades).
DICOM Controlled Terminology (PS3.16 2013 Annex D)
Software R package to analyze immune cell migration data. Supports pipeline for track analysis by providing methods for data management, quality control, extracting and visualizing migration statistics, clustering tracks, and simulating cell migration.Available measures include displacement, confinement ratio, autocorrelation, straightness, turning angle, and fractal dimension. Measures can be applied to entire tracks, steps, or subtracks with varying length.
Facilitates multi‐disciplinary collaboration among imaging scientists and clinicians at academic institutions within the Milwaukee region. Manages MCW research imaging facilities and provides access to MCW faculty imaging specialists. Services include performing mixed research and advanced clinical outpatient imaging to support clinical evaluation trials and basic science/technology research.
An application ontology devoted to the standardized recording of data related to Fanconi Anemia (FA). This ontology was created using an OWL file provided by Dr. Ada Hamish (and Francois Schiettecatte) at the Centers for Mendelian Genetics, with their permission. Their original ontology can be found at: http://phenodb.net/help/features. Modifications were made using HPO, OMIM, NCI, and SNOMED. Novel classes pertaining to FA were added and defined as appropriate.
Comprehensive structural biology resource.Provides high throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and X-ray facility with access to high energy synchrotron radiation. Provides expert guidance to researchers through every stage of project, collaborating and consulting with researchers who use the facilities. Service categories are Chemical, Material and Protein Characterization, Molecular Biology. Services include Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray.
Core is a fee-for-use COBRE core that houses multi-photon microscopes and light microscopes that allow high-resolution visualization of cell and tissue structure (mitochondrial networks, collagen structure), metabolic function (optical redox and NADH fluorescence lifetime measurements), and biomolecular composition (autofluorescent metabolic cofactors, lipid deposition).
A structured controlled vocabulary of stage-specific anatomical structures of the human. It has been designed to mesh with the mouse anatomy and incorporates each Carnegie stage of development (CS1-20). The timed version of the human developmental anatomy ontology gives all the tissues present at each Carnegie Stage (CS) of human development (1-20) linked by a part-of rule. Each term is mentioned only once so that the embryo at each stage can be seen as the simple sum of its parts. Users should note that tissues that are symmetric (e.g. eyes, ears, limbs) are only mentioned once.
Provides advanced instrumentation as well as high level technical and scientific expertise in multi dimensional Flow Cytometry and Cell Sorting, to facilitate science, improve the quality, and advance the scope of MSK research.
Core services include conception, execution and evaluation of functional magnetic resonance imaging studies, fMRI, and positron emission tomography studies, PET. Provides expertise in performance of functional imaging studies.
Ontology that contains terms necessary for describing and categorizing concepts related to Major Histocompatibility Complex, in general, for a number of model species, and also for humans.
Software R package provides misc functions for training and plotting classification and regression models.Contains tools for data splitting, pre-processing, feature selection, model tuning using resampling, and variable importance estimation, as well as other functionality.
Multi-organism database containing interactions and roles of proteins in inter- and intracellular signaling and transcriptional and post-transcriptional regulation.