Curator Dashboard

The UCSD-Nature Signaling Gateway Molecule Pages provide essential information on more than 3900 proteins involved in cellular signaling. Each Molecule Page contains regularly updated information derived from public data sources as well as sequence analysis, references and links to other databases. Published Molecule Pages contain an expert-authored review article that describes the biological activity, regulation and localization of the protein. This review is supplemented by highly structured data that illustrate protein-protein interactions, post-translational modifications, subcellular localization and biological function. :Prior to publication, Nature Publishing Group administers rigorous peer and editorial review of each Molecule Page. The published pages are citable by digital object identifiers (DOIs). All data in the Molecule Pages are freely available to the public. :proteins, cellular signaling, neurobiology, genetic and structural information, biophysical properties, 5-Hydroxytryptamine receptor 2A, 5-Hydroxytryptamine receptor 2B, 5-Hydroxytryptamine Receptor 6, Adrenergic receptor a1a, Adrenergic Receptor 1, Ags1, Ags3, Arg, Darpp32, DCLK1, Dopamine receptor D3, Galanin receptor 1, Galanin receptor 2, (Glutamate receptor, metabotropic, type 1), (Glutamate receptor, metabotropic, type 5), (Glutamate receptor, metabotropic, type 8), Homer 1a, Homer 1b, Homer 1c, Homer 2a, Homer 2b, Homer 3, Laminin 2, Mark1, Mlk3, Neurotensin receptor 1, Neurotensin receptor 2, Trpc3, Trpc6, Trpc7, Trpm1, Trpm3, Trpm6, Trpv4, sequence analysis, protein-protein interactions, post-translational modifications, subcellular localization, biological function, signaling molecules, transcription factors, membrane receptors, Lcmt2, HB-EGF, Pak1, Itpk1, Ubr5, Rab35, CAP1, Plasma membrane calcium transporting ATPase isoform 4, 5-Hydroxytryptamine receptor 2C, Vangl2, mTOR, Catenin, beta, Pak1, Ubr5, Adrenergic receptor alpha 2a, Plasma membrane calcium transporting ATPase isoform 4, PCAF lysine acetyltransferase, G protein alpha 13, Rab35, Cell signaling, molecules, signaling protein, protein-protein interactions, subcellular localizations, post-translational modifications, enzymatic functions, states (A state is a physiological condition of a molecule), functions, transitions, network map, protein class, protein function, regulation of activity, interactions with ligands and other proteins, regulation of concentration (both protein and mRNA), subcellular localization, major sites of expression, phenotypes, splice variants and antibodies, pathways, Domains and Motifs, Orthologs and Blast Data,

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• SciCrunch
• 17 years ago - by Anonymous

University of Pennsylvania is private Ivy League research university located in University City neighborhood of Philadelphia, Pennsylvania. Established in 1740, UPenn has 4 undergraduate schools and 12 graduate schools.

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• SciCrunch
• 14 years ago - submitted by Timothy Tsui

Provides expert advice and guidance for collaborative research projects involving the use of fluorescence and electron microscopy. Access to advanced fluorescence and electron microscopes for external users after a peer-review process.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

A database of domain-domain and peptide-mediated interactions of known 3D structures. The database of 3D Interaction Domains (3did) is a collection of domain-domain and domain-peptide interactions for which high-resolution three-dimensional structures are known. 3did exploits structural information to provide critical molecular details necessary for understanding how these interactions occur. It also offers an overview of how similar in structure are interactions between different members of the same protein family. The database also contains GO-based functional annotations and interactions between yeast proteins from large-scale interaction discovery studies. Sponsors: This resource is partially supported by the Spanish Ministerio de Educacin y Ciencia (PSE-010000-2007-1 and BIO2007-62426) and the 3D-Repertoire from the European Commission under FP6 contract LSHG-CT-2005-512028. Keywords: Database, Domain, Peptide, Protein, 3D structure, Interaction, Dimentional, Structure, Molecular, Functional, Annotation, Interaction, Yeast, Study, Research,

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• SciCrunch
• 17 years ago - by Anonymous

Public research university in Vermillion, South Dakota.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Core provides team of experts in the characterization of immune profiles and treatment responses across a diverse range of diseases, such as cancer, autoimmunity, allergy, and neuro-immune disorders. Offers equipment in the field for research at Genomic, cellular and proteomic analysis. Develops assays to balance innovation with protocols and operating procedures to ensure data quality and reproducibility.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

ChickVD hosts high-quality sequence variation data, variation analysis in the context of chicken genes, cDNAs, chicken orthologs of human disease genes, genetic markers, quantitative trait loci (QTLs) etc . All data are uniquely mapped onto the RJF draft genome and graphically represented in MapView, an efficient visualization tool that allows users to browse sequence variations in the genomic and functional context. The sub-viewer TraceView assists users to view the vivid graphics of the original traces around the detected SNP. Users may query the data by the online search tool and define concrete limitations to extract records that are best suited to their research needs. For the convenience of data presentation in ChickVD, different types of sequence variations (substitutions, insertions or deletions) are all referred as ???SNPs''. ChickVD is updated constantly as more data generated and is under the continued improvement for its content and functionality

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• SciCrunch
• 17 years ago - by Anonymous

UTEP officially opened in the fall of 1914 and is the second oldest institution in The University of Texas System.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Convenience wrapper function around the following three functions that are often run together when mapping query data to a reference: TransferData, IntegrateEmbeddings, ProjectUMAP.

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• RRID
• 1 year ago - submitted by Edyta Vieth

Database that provides human protein interaction information and integrated interaction and also finds proteins from databases that can potentially react with proteins submitted by users. The human protein interaction information was pre-computed by a statistical method from existing structural and experimental data, while the integrated human protein interactions are derived from BIND, DIP and HPRD. A score composed of three parts is assigned to the predicted interaction data, and those interactions with high scores were found reliable. HPID allows the user to use the protein IDs in EMBL, Ensembl, MIM, RefSeq, HPRD and NCBI to search protein interactions of interest. A set of web-based software tools has also been developed so that users can visualize and analyze protein interaction networks.

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• SciCrunch
• 17 years ago - by Anonymous

University of Wisconsin–Madison is a public research university in Madison, Wisconsin.UW–Madison is official state university of Wisconsin, and the flagship campus of the University of Wisconsin System. The UW is one of America's Public Ivy universities, which refers to top public universities in the United States capable of providing a collegiate experience comparable with the Ivy League.

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• SciCrunch
• 14 years ago - submitted by Andrea Stagg

Core supports tissue and body fluid procurement, storage, and tracking from consented and de-identified collections. Pathologists responsible for procurement can be contacted for consultation to determine investigator requirements for human specimens in translational and basic research and then arrange procurement as feasible. Basic histology services include process, embed, and section fixed and frozen tissues (both animal and human), histochemistry, immunohistochemistry, immunofluorescence, in situ hybridization, laser capture microdissection, special stains for routine light microscopic evaluation. Offers full digital scanning capability with our quantitative and qualitative digital image analysis service (HALO), and support DNA/RNA/miRNA extraction from fluids and tissue specimens (both fixed and frozen) for downstream next generation sequencing and other applications.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

A manually curated database, aims at providing a comprehensive resource of miRNA deregulation in various human diseases. Each entry in the miR2Disease contains detailed information on a miRNA-disease relationship, including miRNA ID, disease name, a brief description of the miRNA-disease relationship, miRNA expression pattern in the disease state, detection method for miRNA expression, experimentally verified miRNA target gene(s), and literature reference . All entries can be retrieved by miRNA ID, disease name or target gene. miR2Disease will be updated bimonthly. miR2Disease sincerely looks forward to recently established relationship between miRNA and human diseases to be submitted.

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• SciCrunch
• 17 years ago - by Anonymous

Waikato University, is a comprehensive university in Hamilton, New Zealand. The university was established in 1964, and has an additional campus located in Tauranga.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core provides multiphoton characterization of Genetically-Encoded Probes for the BRAIN Initiative researchers and broader neuroscience community. Services include Measuring of 2-photon absorption spectra in absolute, cross section values; Measuring 3-photon absorption spectra and cross sections; Characterizing multiphoton photobleaching parameters, i.e. quantum yields, nonlinear absorption cross sections:Measuring one-photon absorption, emission, and excitation spectra;Measuring fluorescence quantum yields and lifetimes;Evolving brighter two-photon probes.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

THIS RESOURCE IS NO LONGER IN SERVICE, documented April 14, 2017. The Rat Genome Database RatMap is focused on presenting rat genes, DNA-markers, QTL's, etc. that is localized to chromosome. The database is dedicated to rat gene nomenclature and should be consulted for queries in such matters.

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• SciCrunch
• 17 years ago - by Anonymous

Private research university in Winston-Salem, North Carolina.

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• SciCrunch
• 13 years ago - submitted by Eddy Kim

Software R package for analysis of multivariate dichotomous and polytomous data using latent trait models under the Item Response Theory approach.

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• RRID
• 1 year ago - by Anonymous

GenePath is a web-enabled intelligent assistant for the analysis of genetic data and for discovery of genetic networks. GenePath uses abductive inference to elucidate network constraints and logic to derive consistent networks. Typically, it starts with a set of genetic experiments, uses a set of embedded rules (patterns) to infer relations between genes and outcome, and based on these relations constructs a genetic network.

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• SciCrunch
• 17 years ago - by Anonymous

The Bioinformatics Institute (BII) was set up by the Agency for Science and Technology Research (A*STAR) in July 2001; it was re-launched with a strong scientific program in the autumn months of 2007. Located in the Biopolis, BII is conceived as the computational biology research and postgraduate training institute as well as a national resource centre in bioinformatics within the Biomedical Research Council (BMRC) of A*STAR. The BII focuses on theoretical approaches aimed at understanding biomolecular mechanisms that underlie biological phenomena, the development of computational methods to support this discovery process, and experimental verification of predicted molecular and cellular functions of genes and proteins with biochemical methods. Together with the BMRC, A*STAR research institutes and multinational R&D organizations in the Biopolis, the BII is situated in a conducive environment for exchange of scientific knowledge and friendly interaction that will prompt greater collaborations, and position the Biopolis as a notable biomedical R&D hub in Asia and in the world.

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• SciCrunch
• 17 years ago - submitted by Christie Wang