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Ischemic stroke (IS) imposes a major global health burden. To uncover new diagnostic and therapeutic targets, we profiled neuronal heterogeneity during IS using single-cell RNA sequencing. Our analysis decoded neuronal lineage trajectories, identified a critical cell-cell communication network, and pinpointed key gene modules. By integrating multiple machine learning algorithms, we constructed a highly accurate diagnostic model based on the hub genes Il18 and Cherp. This model was rigorously validated across multi-omics datasets and species. We further confirmed that Cherp promotes neuronal repair by regulating calcium homeostasis, while Il18 serves as a potential early blood biomarker. This work provides effective targets and translatable tools for advancing IS precision medicine.
Pubmed ID: 42291234
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Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsOpen source software package for statistical programming language R to create plots based on grammar of graphics. Used for data visualization to break up graphs into semantic components such as scales and layers.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets CHERP
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