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Narcissoside attenuates atherosclerosis by suppressing CD36-mediated foam cell formation via upregulation of NR4A1.

Ziyuan Wang | Lamei Zhou | Xiaorong Zhang | Zhiren Yao | Yaping Huang | Lei Wang | Ke Pan | Jian Zhang | Hao Zhi | Zhiqi Yin
Chinese medicine | 2026

The formation of foam cells (FCs) is the major contributor to the development of atherosclerosis (AS). Gynostemma pentaphyllum is widely used to treat AS and exhibits biological activity against FCs formation. Narcissoside (Nar) is an important component from G. pentaphyllum flavonoids. This study aimed to reveal the beneficial effect and underlying mechanism of Nar on inhibiting the formation of FCs in AS.

Pubmed ID: 42163363

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: Wellcome Trust, United Kingdom
    Id: 202101
  • Agency: the National Natural Science Foundation of China,
    Id: 82304337
  • Agency: the China Postdoctoral Science Foundation,
    Id: 2023M733899
  • Agency: the Jiangsu Funding Program for Excellent Postdoctoral Talent,
    Id: 2023ZB721
  • Agency: the Natural Science Foundation of Jiangsu Province Academy of Traditional Medicine,
    Id: 2024YZRKXJJ21

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