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The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis.

Xiaojie Zhao | Yufeng Xiong | Xuke Qin | Jianxin Hu | Shiyu Huang | Xinmiao Ni | Jun Jian | Song Yang | Xiaodong Weng | Hui Chen | Zhiyuan Chen | Xiuheng Liu | Lei Wang
Cellular & molecular biology letters | 2025

Chronic kidney disease (CKD) is characterized by progressive renal fibrosis, which contributes to disease progression and ultimately leads to kidney failure. Circular RNAs (circRNAs) are key regulators in various fibrotic diseases, showing different expression patterns in different organs. However, the exact role and mechanisms of circRNAs in renal fibrosis are still not fully understood.

Pubmed ID: 41351065

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: No.82460293
  • Agency: National Natural Science Foundation of China,
    Id: No.82372200
  • Agency: Science and Technology Program of Guizhou, China,
    Id: ZK-2024-482
  • Agency: Natural Science Foundation of Hubei Province,
    Id: No.2025AFB803

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This is a list of tools and resources that we have found mentioned in this publication.


UCSC Genome Browser (tool)

RRID:SCR_005780

Portal to interactively visualize genomic data. Provides reference sequences and working draft assemblies for collection of genomes and access to ENCODE and Neanderthal projects. Includes collection of vertebrate and model organism assemblies and annotations, along with suite of tools for viewing, analyzing and downloading data.

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Circos (tool)

RRID:SCR_011798

A software package for visualizing data and information. It visualizes data in a circular layout - this makes Circos ideal for exploring relationships between objects or positions.

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DESeq2 (tool)

RRID:SCR_015687

Software package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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