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Publication

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.

Yani Pan | Nannan Zhang | Xueni Fu | Xinyu Wang | Yichun Ma | Qi Chen | Yue Zhou | Hongwen Liu | Yun Zhu | Lei Xu | Qiang Wang | Dongyin Chen | Zhangding Wang | Lei Wang
Journal of experimental & clinical cancer research : CR | 2025

Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA). While our prior study highlighted glycogen degradation as pivotal for CCA tumorigenesis, the molecular mechanisms governing lipogenesis and its therapeutic exploitation remain elusive.

Pubmed ID: 41291880

Research resources used in this publication

None found

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Antibodies used in this publication

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Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: 82473107
  • Agency: National Natural Science Foundation of China,
    Id: 82573296
  • Agency: Nanjing special foundation for health science and technology development,
    Id: JQX22005
  • Agency: the Health Research Program of Anhui,
    Id: AHWJ2024Aa20050
  • Agency: Jiangsu provincial key research and development program,
    Id: BE2023655
  • Agency: Jiangsu Provincial Medical Innovation Center for Digestive Disease,
    Id: CXZX202213

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

BALB/cAnN-Foxn1nu/nu/Rj (tool)

RRID:IMSR_RJ:BALB-C-NUDE

Mus musculus with name BALB/cAnN-Foxn1nu/nu/Rj from IMSR.

View all literature mentions

C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

View all literature mentions

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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Department of Neurosciences, School of Medicine

University of California, San Diego

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