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Publication

Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by facilitating M2 polarization via CCL2/CCR2 axis and further inducing formation of regulatory CCR2 + CD4 + T cells.

Chao Xue | Wei Liu | Yuan Li | Yue Yin | Bo Tang | Jinye Zhu | Yujun Dong | Huihui Liu | Hanyun Ren
Stem cell research & therapy | 2025

Our previous study revealed that mesenchymal stem cells (MSCs) can secrete large amounts of the chemokine CCL2 under inflammatory conditions and alleviate idiopathic pneumonia syndrome (IPS) by promoting regulatory CCR2 + CD4 + T-cell formation through the CCL2‒CCR2 axis. Given the abundance of macrophages in lung tissue, how these macrophages are regulated by MSC-based prophylaxis via IPS and their interactions with T cells in lung tissue during allo-HSCT are still not fully understood.

Pubmed ID: 40025564

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Associated grants

  • Agency: National Natural Science Foundation of China,
    Id: 81970160
  • Agency: National Natural Science Foundation of China,
    Id: 81570160
  • Agency: National Natural Science Foundation of China,
    Id: 82071757

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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