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Protective Effect of Nicotinamide Riboside on Glucocorticoid-Induced Glaucoma: Mitigating Mitochondrial Damage and Extracellular Matrix Deposition.

Nan Zhang | Pengyu Zhang | Xizhi Deng | Min Zhu | Yixin Hu | Dongxiao Ji | Lufan Li | Yang Liu | Wen Zeng | Min Ke
Investigative ophthalmology & visual science | 2024

Glucocorticoid-induced glaucoma (GIG) is a prevalent complication associated with glucocorticoids (GCs), resulting in irreversible blindness. GIG is characterized by the abnormal deposition of extracellular matrix (ECM) in the trabecular meshwork (TM), elevation of intraocular pressure (IOP), and loss of retinal ganglion cells (RGCs). The objective of this study is to investigate the effects of nicotinamide riboside (NR) on TM in GIG.

Pubmed ID: 38949632

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