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Polo-like kinase 1 promotes pulmonary hypertension.

Rongrong Chen | Hongfei Wang | Cuiting Zheng | Xiyu Zhang | Li Li | Shengwei Wang | Hongyu Chen | Jing Duan | Xian Zhou | Haiyong Peng | Jing Guo | Anchen Zhang | Feifei Li | Wang Wang | Yu Zhang | Jun Wang | Chen Wang | Yan Meng | Xinling Du | Hongbing Zhang
Respiratory research | 2023

Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. The aim of this study was to investigate the role of mitotic regulator Polo-like kinase 1 (PLK1) in PH development.

Pubmed ID: 37598171

Associated grants

  • Agency: the National Key R&D Program, Ministry of Science and Technology of China,
    Id: 2021YFC2500700
  • Agency: Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences,
    Id: 2021-I2M-1-049

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