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Publication

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma.

Zhewen Xiong | Stephen Lam Chan | Jingying Zhou | Joaquim S L Vong | Tsz Tung Kwong | Xuezhen Zeng | Haoran Wu | Jianquan Cao | Yalin Tu | Yu Feng | Weiqin Yang | Patrick Pak-Chun Wong | Willis Wai-Yiu Si-Tou | Xiaoyu Liu | Jing Wang | Wenshu Tang | Zhixian Liang | Jiahuan Lu | Ka Man Li | Jie-Ting Low | Michael Wing-Yan Chan | Howard H W Leung | Anthony W H Chan | Ka-Fai To | Kevin Yuk-Lap Yip | Yuk Ming Dennis Lo | Joseph Jao-Yiu Sung | Alfred Sze-Lok Cheng
Gut | 2023

Therapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed to investigate the mechanisms underlying tumour adaptation to immune-checkpoint targeting.

Pubmed ID: 37019619

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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