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Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type 2 diabetes mellitus (T2DM). However, the effect of HUA on glucose uptake and the insulin sensitivity of macrophages and its mechanism is unclear.
Pubmed ID: 36177037
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Bioinformatics resource system including web server and web service for functional annotation and enrichment analyses of gene lists. Consists of comprehensive knowledgebase and set of functional analysis tools. Includes gene centered database integrating heterogeneous gene annotation resources to facilitate high throughput gene functional analysis.
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets PI3 Kinase p85
View all literature mentionsThis unknown targets IL-1 beta
View all literature mentionsThis monoclonal targets ACTB
View all literature mentionsThis polyclonal targets LAMP1
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis unknown targets CCL2 (MCP-1)
View all literature mentionsThis unknown targets IL-6
View all literature mentionsThis monoclonal targets AMPK alpha
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets F4/80 antibody [CI:A3-1]
View all literature mentionsThis polyclonal targets
View all literature mentionsThis monoclonal targets AS160 (C69A7) Rabbit mAb
View all literature mentionsThis monoclonal targets AMPKA1;AMPKA2
View all literature mentionsThis polyclonal targets Glucose Transporter GLUT4
View all literature mentionsThis polyclonal targets Phospho-mTOR (Ser2448)
View all literature mentionsThis polyclonal targets IRS-2 (L1326)
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsCell line THP-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentions