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Publication

Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by modulating T cell function through CCR2-CCL2 axis.

Min Cao | Huihui Liu | Yujun Dong | Wei Liu | Zhengyu Yu | Qingya Wang | Qingyun Wang | Zeying Liang | Yuan Li | Hanyun Ren
Stem cell research & therapy | 2021

Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Conventional immunosuppressive treatments for IPS have poor therapeutic effects. Safe and effective treatments are not yet available and under explorations. Our previous study demonstrated that mesenchymal stem cells (MSCs) can alleviate IPS, but the mechanisms remain unclear.

Pubmed ID: 34215321

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