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Publication

Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program.

Hyunbae Kim | Juncheng Wei | Zhenfeng Song | Emilio Mottillo | Lobelia Samavati | Ren Zhang | Li Li | Xuequn Chen | Bhanu P Jena | Jiandie D Lin | Deyu Fang | Kezhong Zhang
Molecular metabolism | 2021

The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protein degradation program in hepatic energy metabolism.

Pubmed ID: 33592335

Research resources used in this publication

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK089503
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK090313
  • Agency: NIEHS NIH HHS, United States
    Id: R21 ES017829
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK020572
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK110314
  • Agency: NIAMS NIH HHS, United States
    Id: R01 AR066634
  • Agency: NCI NIH HHS, United States
    Id: R01 CA232347
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK120330

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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Huh-7 (tool)

RRID:CVCL_0336

Cell line Huh-7 is a Cancer cell line with a species of origin Homo sapiens (Human)

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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