Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver disease (NAFLD). In the livers of mice suffering from NAFLD, NK cells are less able to degranulate, express lower levels of perforin and are less able to kill cancerous target cells than those from healthy animals. This is associated with a decreased ability to kill cancer cells in vivo. On the other hand, we find that perforin-deficient mice suffer from less severe NAFLD, suggesting that this reduction in NK cell cytotoxicity may be protective in the obese liver, albeit at the cost of increased susceptibility to cancer. The decrease in cytotoxicity is associated with a shift toward a transcriptional profile characteristic of ILC1, increased expression of the ILC1-associated proteins CD200R1 and CD49a, and an altered metabolic profile mimicking that of ILC1. We show that the conversion of NK cells to this less cytotoxic phenotype is at least partially mediated by TGFβ, which is expressed at high levels in the obese liver. Finally, we show that reduced cytotoxicity is also a feature of NK cells in the livers of human NAFLD patients.
Pubmed ID: 31572388
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD223
View all literature mentionsThis monoclonal targets Human CD45 (LCA)
View all literature mentionsThis monoclonal targets CD56 (NCAM-1)
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets EOMES
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD49b (Integrin alpha 2)
View all literature mentionsThis monoclonal targets CD49a (Integrin α1 chain)
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP Rabbit mAb
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets Glut1
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD49b (Integrin alpha 2)
View all literature mentionsThis monoclonal targets Perforin
View all literature mentionsThis monoclonal targets T-bet
View all literature mentionsThis monoclonal targets CD107a (LAMP-1)
View all literature mentionsThis monoclonal targets CD200R
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsSoftware package as a DESeq2- and EdgeR-Based R Pipeline for Comprehensive Differential Analysis of RNA-Seq Data.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentions