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GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis.

Linwei Li | Pengyu Tang | Zheng Zhou | Qian Wang | Tao Xu | Shujie Zhao | Yifan Huang | Fanqi Kong | Wei Liu | Lin Cheng | Zhimin Zhou | Xuan Zhao | Changjiang Gu | Yongjun Luo | Gaojian Tao | Dingfei Qian | Jian Chen | Jin Fan | Guoyong Yin
Cell proliferation | 2019

Osteogenesis is coupled with angiogenesis during bone remodelling. G-protein-coupled receptor (GPCR) kinase 2-interacting protein-1 (GIT1) is an important protein that participates in fracture healing by regulating angiogenesis. This study investigated whether GIT1 could affect bone mesenchymal stem cells (BMSCs) to secrete angiogenic factors to enhance fracture healing by promoting angiogenesis and its possible mechanism.

Pubmed ID: 31502302

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