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Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells.

Yunxia Zhu | Xiaoyan Zhang | Li Zhang | Mingliang Zhang | Ling Li | Deng Luo | Yuan Zhong
Nutrition & metabolism | 2019

Chronic exposure of pancreatic β-cells to excess free fatty acids is thought to contribute to type 2 diabetes pathogenesis in obesity by impairing β-cell function and even leading to apoptosis. In β-cells, lipid droplet-associated protein perilipin 5 (PLIN5) has been shown to enhance insulin secretion by regulating intracellular lipid metabolism; the roles of PLIN5 in response to lipotoxicity remain poorly understood.

Pubmed ID: 31384284

Associated grants

None

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