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PPP1R3C mediates metformin-inhibited hepatic gluconeogenesis.

Xueying Ji | Shushu Wang | Hongju Tang | Yuqing Zhang | Feiye Zhou | Linlin Zhang | Qin Zhu | Kecheng Zhu | Qianqian Liu | Yun Liu | Xiao Wang | Libin Zhou
Metabolism: clinical and experimental | 2019

Metformin has been widely used to alleviate hyperglycemia in patients with type 2 diabetes mainly via suppressing hepatic gluconeogenesis. However, the underlying mechanism remains incompletely clear. Here, we aimed to explore the role of PPP1R3C in metformin-mediated inhibition of hepatic gluconeogenesis.

Pubmed ID: 31181215

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