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DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.

Ming Yang | Li Zhao | Peng Gao | Xuejing Zhu | Yachun Han | Xianghui Chen | Li Li | Ying Xiao | Ling Wei | Chenrui Li | Li Xiao | Shuguang Yuan | Fuyou Liu | Lily Q Dong | Yashpal S Kanwar | Lin Sun
EBioMedicine | 2019

The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, and it plays a vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed in the MAM, serves as an antioxidant and reduces ER stress. However, the role of DsbA-L and MAM in kidney pathobiology remains unclear.

Pubmed ID: 31060900

Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK060635
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK114479

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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RRID:SCR_002865

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Proteintech Group (tool)

RRID:SCR_008986

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RRID:SCR_013311

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RRID:SCR_013554

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HK-2 [Human kidney] (tool)

RRID:CVCL_0302

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

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