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Neointimal hyperplasia is a prominent pathological event during in-stent restenosis. Phenotype switching of vascular smooth muscle cells (VSMCs) from a differentiated/contractile to a dedifferentiated/synthetic phenotype, accompanied by migration and proliferation of VSMCs play an important role in neointimal hyperplasia. However, the molecular mechanisms underlying phenotype switching of VSMCs have yet to be fully understood.
Pubmed ID: 30579864
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Open source database of curated, non-redundant set of profiles derived from published collections of experimentally defined transcription factor binding sites for multicellular eukaryotes. Consists of open data access, non-redundancy and quality. JASPAR CORE is smaller set that is non-redundant and curated. Collection of transcription factor DNA-binding preferences, modeled as matrices. These can be converted into Position Weight Matrices (PWMs or PSSMs), used for scanning genomic sequences. Web interface for browsing, searching and subset selection, online sequence analysis utility and suite of programming tools for genome-wide and comparative genomic analysis of regulatory regions. New functions include clustering of matrix models by similarity, generation of random matrices by sampling from selected sets of existing models and a language-independent Web Service applications programming interface for matrix retrieval.
View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis recombinant monoclonal targets Ki67
View all literature mentionsThis polyclonal targets alpha smooth muscle Actin
View all literature mentionsThis monoclonal targets Pdgfb
View all literature mentionsThis monoclonal targets PCNA
View all literature mentionsThis polyclonal targets CD31/PECAM-1
View all literature mentionsThis polyclonal targets alpha smooth muscle Actin
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets p53 (1C12) Mouse mAb
View all literature mentionsThis recombinant monoclonal targets PDGF Receptor beta
View all literature mentions