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Publication

6% Hydroxyethyl starch (HES 130/0.4) diminishes glycocalyx degradation and decreases vascular permeability during systemic and pulmonary inflammation in mice.

Andreas Margraf | Jan M Herter | Katharina Kühne | Anika Stadtmann | Thomas Ermert | Manuel Wenk | Melanie Meersch | Hugo Van Aken | Alexander Zarbock | Jan Rossaint
Critical care (London, England) | 2018

Increased vascular permeability is a pathophysiological hallmark of sepsis and results in increased transcapillary leakage of plasma fluid, hypovolemia, and interstitial edema formation. 6% hydroxyethyl starch (HES 130/0.4) is commonly used to treat hypovolemia to maintain adequate organ perfusion and oxygen delivery. The present study was designed to investigate the effects of 6% HES 130/0.4 on glycocalyx integrity and vascular permeability in lipopolysaccharide (LPS)-induced pulmonary inflammation and systemic inflammation in mice.

Pubmed ID: 29716625

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Associated grants

  • Agency: Fresenius Biotech,
    Id: unrestricted research grant

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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