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Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway.

Sufan Wang | Ting Wan | Mingtong Ye | Yun Qiu | Lei Pei | Rui Jiang | Nengzhi Pang | Yuanling Huang | Baoxia Liang | Wenhua Ling | Xiaojun Lin | Zhenfeng Zhang | Lili Yang
Redox biology | 2018

Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+) precursor which is present in foods such as milk and beer. It was reported that NR can prevent obesity, increase longevity, and promote liver regeneration. However, whether NR can prevent ethanol-induced liver injuries is not known. This study aimed to explore the effect of NR on ethanol induced liver injuries and the underlying mechanisms.

Pubmed ID: 29679894

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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