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Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease.

Camila Iansen Irion | Bruno Diaz Paredes | Guilherme Visconde Brasil | Sandro Torrentes da Cunha | Luis Felipe Paula | Alysson Roncally Carvalho | Antonio Carlos Campos de Carvalho | Adriana Bastos Carvalho | Regina Coeli Dos Santos Goldenberg
Memorias do Instituto Oswaldo Cruz | 2017

Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects in the heart are unknown. Reports have suggested that bone marrow cells are recruited to the chagasic heart; however, studies using chimeric mouse models of chagasic cardiomyopathy are rare.

Pubmed ID: 28767980

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