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Bidirectional regulation of angiogenesis and miR-18a expression by PNS in the mouse model of tumor complicated by myocardial ischemia.

Qinbo Yang | Xiaoyan Wang | Jingang Cui | Peiwei Wang | Minqi Xiong | Chenglin Jia | Li Liu | Bingbing Ning | Li Li | Wenjian Wang | Yu Chen | Teng Zhang
BMC complementary and alternative medicine | 2014

Panax Notoginseng Saponins (PNS) is the major class of active constituents of notoginseng, a natural product extensively used as a therapeutic agent in China. Tumor when accompanied by cardiovascular disorders poses a greater challenge for clinical management given the paradoxical involvement of angiogenesis, therefore gaining increased research attention. This study aim to investigate effects of PNS and its activity components in the mouse model of tumor complicated with myocardial ischemia.

Pubmed ID: 24903055

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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