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DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.

Mathieu Amand | Charlotte Erpicum | Khalid Bajou | Fabio Cerignoli | Silvia Blacher | Maud Martin | Franck Dequiedt | Pierre Drion | Pratibha Singh | Tinatin Zurashvili | Maud Vandereyken | Lucia Musumeci | Tomas Mustelin | Michel Moutschen | Christine Gilles | Agnes Noel | Souad Rahmouni
Molecular cancer | 2014

DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive.

Pubmed ID: 24886454

Research resources used in this publication

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Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: 5R01AI035603

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Imaris (tool)

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