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Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.

Peter E Westerweel | Martin Teraa | Shahin Rafii | Janneke E Jaspers | Ian A White | Andrea T Hooper | Pieter A Doevendans | Marianne C Verhaar
PloS one | 2013

Circulating Endothelial Progenitor Cell (EPC) levels are reduced in diabetes mellitus. This may be a consequence of impaired mobilization of EPC from the bone marrow. We hypothesized that under diabetic conditions, mobilization of EPC from the bone marrow to the circulation is impaired -at least partly- due to dysfunction of the bone marrow stromal compartment.

Pubmed ID: 23555959

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Associated grants

  • Agency: Howard Hughes Medical Institute, United States

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