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Publication

A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy.

Lauren E Ta | James D Schmelzer | Allan J Bieber | Charles L Loprinzi | Gary C Sieck | Jill D Brederson | Philip A Low | Anthony J Windebank
PloS one | 2013

Chemotherapy-induced neuropathy is the principle dose limiting factor requiring discontinuation of many chemotherapeutic agents, including cisplatin and oxaliplatin. About 30 to 40% of patients receiving chemotherapy develop pain and sensory changes. Given that poly (ADP-ribose) polymerase (PARP) inhibition has been shown to provide neuroprotection, the current study was developed to test whether the novel PARP inhibitor compound 4a (analog of ABT-888) would attenuate pain in cisplatin and oxaliplatin-induced neuropathy in mice.

Pubmed ID: 23326593

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Associated grants

  • Agency: NIDCR NIH HHS, United States
    Id: R03 DE020868
  • Agency: NCI NIH HHS, United States
    Id: U10 CA037404
  • Agency: NIDCR NIH HHS, United States
    Id: DE020868
  • Agency: NCI NIH HHS, United States
    Id: CA37404

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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The Stimulating Peripheral Activity to Relieve Conditions (SPARC) effort is the result of National Institutes of Health’s (NIH) drive to map out the neural circuitry responsible for visceral control in higher vertebrates. The SPARC Anatomy Working Group (SAWG) is responsible for the integrity of anatomical knowledge in SPARC

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