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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Anti-tumor Immune Response in Patients With Cancer Undergoing Radiation Therapy | Recruiting | Malignant Neoplasm | Other, Other - cytology specimen collection procedure, laboratory biomarker analysis | Jonsson Comprehensive Cancer Center, Other | 18 Years - N/A | Observational | This research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response. | |||
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Clinicaltrials.gov | Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior | Recruiting | Breast Cancer | Other, Other, Procedure - biologic sample preservation procedure, laboratory biomarker analysis, biopsy | UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Observational | RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research study is looking at tissue and blood samples from women with locally advanced or metastatic breast cancer | |||
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Clinicaltrials.gov | Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers | Recruiting | Esophageal Cancer, Head and Neck Cancer, Lung Cancer, Precancerous Condition | Other, Other, Other, Procedure - immunohistochemistry staining method, laboratory biomarker analysis, sputum cytology, biopsy | University of Colorado, Denver, National Cancer Institute (NCI), Other, NIH | 21 Years - 90 Years | Observational | RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer. | |||
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Clinicaltrials.gov | Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Patients and Healthy Participants | Recruiting | Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Precancerous Condition | Genetic, Genetic, Other, Other, Other, Procedure, Procedure, Procedure, Procedure, Procedure, Procedure - protein analysis, proteomic profiling, biologic sample preservation procedure, laboratory biomarker analysis, medical chart review, diagnostic colonoscopy, diagnostic endoscopic procedure, diagnostic endoscopic surgery, diagnostic surgical procedure, endoscopic surgery, screening colonoscopy | Vanderbilt University Medical Center, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Observational | RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy participants may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is looking at gastrointestinal biomarkers in tissue and biological fluid samples from patients and healthy participants undergoing colonoscopy, endoscopy, or surgery. | |||
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Clinicaltrials.gov | Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors | Recruiting | Unspecified Adult Solid Tumor, Protocol Specific | Genetic, Other, Other - mutation analysis, cytology specimen collection procedure, laboratory biomarker analysis | Stanford University, Other | 18 Years - N/A | Observational | This research trial studies using genomic profiling to recommend anticancer treatment to patients with cancer that has spread beyond the original site of the tumor (metastatic cancer). Genomic profiling studies the deoxyribonucleic acid (DNA) of a tumor to detect genetic changes or abnormalities. This information can then be used to recommend treatments that may be more likely to result in a beneficial response. It is not yet known whether genomic profiling will detect abnormalities that can be used to make treatment recommendations and whether treatment based on genomic profiling is more effective than standard treatment. | |||
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Clinicaltrials.gov | Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma | Recruiting | Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma | Radiation, Radiation, Radiation, Radiation, Radiation, Drug, Other - 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy, photon beam radiation therapy, intensity-modulated radiation therapy, proton beam radiation therapy, temozolomide, laboratory biomarker analysis | NRG Oncology, National Cancer Institute (NCI), Radiation Therapy Oncology Group, Other, NIH, Other | 18 Years - N/A | Phase 2 | Interventional | This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and shrink tumors. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs, such as temozolomide, may make tumor cells more sensitive to radiation therapy. It is not yet known whether dose-escalated photon IMRT or proton beam radiation therapy is more effective than standard-dose radiation therapy with temozolomide in treating glioblastoma. | ||
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Clinicaltrials.gov | Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer | Recruiting | Recurrent Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer | Other, Other - cytology specimen collection procedure, laboratory biomarker analysis | Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | N/A | Interventional | This research trial studies comprehensive genomic analysis in tissue samples from patients with non-small cell lung cancer that has come back or is stage IV. Comprehensive genomic analysis may identify specific gene mutations (changes in deoxyribonucleic acid [DNA]) and help doctors to tailor treatment to target the specific mutations. | ||
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Clinicaltrials.gov | Afatinib in Advanced Refractory Urothelial Cancer | Recruiting | Distal Urethral Cancer, Proximal Urethral Cancer, Recurrent Bladder Cancer, Recurrent Urethral Cancer, Stage III Bladder Cancer, Stage III Urethral Cancer, Stage IV Bladder Cancer, Stage IV Urethral Cancer, Ureter Cancer | Drug, Other - afatinib dimaleate, laboratory biomarker analysis | University of Chicago, National Cancer Institute (NCI), Other, NIH | 18 Years - N/A | Phase 2 | Interventional | This phase II trial studies how well afatinib dimaleate works in treating patients with urothelial cancer that cannot be removed surgically and has grown after treatment with standard first-line chemotherapy. Afatinib dimaleate may turn off the function of the epidermal growth factor (EGF) and human epidermal growth factor receptor 2 (HER2) receptors, which may slow the growth of cancer cells or cause some of the cells to die. | ||
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Clinicaltrials.gov | Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies | Recruiting | Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13, q22), Adult Acute Myeloid Leukemia With t(15, 17)(q22, q12), Adult Acute Myeloid Leukemia With t(16, 16)(p13, q22), Adult Acute Myeloid Leukemia With t(8, 21)(q22, q22), de Novo Myelodysplastic Syndromes, Previously Treated Myelodysplastic Syndromes, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia, Secondary Myelodysplastic Syndromes, Untreated Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Myeloid Leukemia | Radiation, Drug, Biological, Drug, Drug, Procedure, Procedure, Procedure, Other - radiation therapy, cyclophosphamide, anti-thymocyte globulin, tacrolimus, methotrexate, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation, laboratory biomarker analysis | Ohio State University Comprehensive Cancer Center, Other | 18 Years - 75 Years | N/A | Interventional | This pilot clinical trial aims to assess feasibility and tolerability of using an LINAC based "organ-sparing marrow-targeted irradiation" to condition patients with high-risk hematological malignancies who are otherwise ineligible to undergo myeloablative Total body irradiation (TBI)-based conditioning prior to allogeneic stem cell transplant. The target patient populations are those with ALL, AML, MDS who are either elderly (>50 years of age) but healthy, or younger patients with worse medical comorbidities (HCT-Specific Comorbidity Index Score (HCT-CI) > 4). The goal is to have the patients benefit from potentially more efficacious myeloablative radiation based conditioning approach without the side effects associated with TBI. | ||
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Clinicaltrials.gov | Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions | Recruiting | Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion, HIV Infection | Drug, Drug, Other, Other - imiquimod, fluorouracil, questionnaire administration, laboratory biomarker analysis | AIDS Malignancy Consortium, National Cancer Institute (NCI), The Emmes Company, LLC, University of Arkansas, Other, NIH, Industry, Other | 25 Years - N/A | Phase 3 | Interventional | This randomized phase III trial studies imiquimod or fluorouracil to see how well they work compared to observation in treating patients with high-grade anal squamous skin lesions who are human immunodeficiency virus (HIV)-positive. Biological therapies, such as imiquimod, may stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether imiquimod or fluorouracil is more effective than observation in treating high-grade anal squamous skin lesions. | ||
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Clinicaltrials.gov | Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod | Recruiting | Ependymoma | Biological, Drug, Other, Other, Other, Other - HLA-A2 restricted synthetic tumor antigen, Imiquimod, enzyme-linked immunosorbent assay, flow cytometry, immunohistochemistry staining method, laboratory biomarker analysis | Ian F. Pollack, M.D., Solving Kids' Cancer, National Cancer Institute (NCI), Other, Other, NIH | 12 Months - 21 Years | Phase 1 | Interventional | The purpose of this study is to see if vaccination with HLA-A2 restricted peptides, combined with the immunoadjuvant imiquimod is safe and can induce immune responses in children with recurrent ependymomas. Eligible patients are stratified by primary tumor location. | ||
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Clinicaltrials.gov | Assessment of Candidate Protein Expression in Breast Cancer Specimens | Recruiting | Breast Cancer | Genetic, Other, Other - gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis | Case Comprehensive Cancer Center, Other | N/A - N/A | Observational | RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor tissue samples from patients who have undergone surgery for breast cancer. | |||
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Clinicaltrials.gov | Collection of Samples and Clinical Data From Patients With Amyloid Diseases | Recruiting | Multiple Myeloma | Genetic, Genetic, Genetic, Other, Other, Procedure, Procedure - clonality analysis, polymerase chain reaction, protein analysis, biologic sample preservation procedure, laboratory biomarker analysis, fluorescence spectroscopy, quality-of-life assessment | Boston Medical Center, Other | 18 Years - N/A | Observational | RATIONALE: Collecting and storing samples of blood, urine, tissue and data from patients with amyloid diseases to test in the laboratory may help the study of this disease in the future. PURPOSE: This research study is collecting samples from patients with amyloid diseases | |||
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Clinicaltrials.gov | Low-Fat Diet and Fish Oil in Men on Active Surveillance for Prostate Cancer | Recruiting | Adenocarcinoma of the Prostate, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer | Behavioral, Behavioral, Dietary Supplement, Other - behavioral dietary intervention, behavioral dietary intervention, omega-3 fatty acid, laboratory biomarker analysis | Jonsson Comprehensive Cancer Center, National Cancer Institute (NCI), Pharmavite LLC, Seafood Industry Research Fund, Other, NIH, Industry, Other | Male | 50 Years - 80 Years | N/A | Interventional | This randomized phase II trial will evaluate if a low-fat diet with fish oil has the potential to delay disease progression in patients with prostate cancer undergoing active surveillance. | |
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Clinicaltrials.gov | Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot be Removed by Surgery | Recruiting | Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer | Radiation, Other - yttrium Y 90 glass microspheres, laboratory biomarker analysis | Ohio State University Comprehensive Cancer Center, Other | 8 Years - N/A | N/A | Interventional | This clinical trial studies radiolabeled glass beads (yttrium Y 90 glass microspheres) in treating patients with unresectable hepatocellular carcinoma. Internal radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Using radiolabeled glass beads to kill tumor cells may be an effective treatment for liver cancer. | ||
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Clinicaltrials.gov | Controlled Low Calorie Diet in Reducing Side Effects and Increasing Response to Chemotherapy in Patients With Breast or Prostate Cancer | Recruiting | Breast Cancer, Hormone-resistant Prostate Cancer, Recurrent Prostate Cancer | Dietary Supplement, Procedure, Other - dietary intervention, nutritional support, laboratory biomarker analysis | University of Southern California, National Cancer Institute (NCI), Mayo Clinic, Other, NIH, Other | 19 Years - N/A | N/A | Interventional | This randomized phase II trial studies how well a controlled low calorie diet works in reducing side effects and increasing response to chemotherapy in patients with breast or prostate cancer. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Eating a special diet with low calories may reduce the side effects of chemotherapy and improve the response to treatment | ||
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Clinicaltrials.gov | Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer | Recruiting | Lung Cancer | Genetic, Genetic, Genetic, Other, Other, Other - gene expression analysis, microarray analysis, protein expression analysis, biologic sample preservation procedure, laboratory biomarker analysis, matrix-assisted laser desorption/ionization time of flight mass spectrometry | Vanderbilt-Ingram Cancer Center, National Cancer Institute (NCI), Other, NIH | 18 Years - 120 Years | Observational | RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer. | |||
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Clinicaltrials.gov | Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer | Recruiting | Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression, Fatigue, Psychosocial Effects of Cancer and Its Treatment, Sleep Disorders, Excercise | Behavioral, Other, Other, Other, Other, Other, Procedure, Procedure, Other, Other - exercise intervention, counseling intervention, educational intervention, laboratory biomarker analysis, questionnaire administration, study of socioeconomic and demographic variables, fatigue assessment and management, quality-of-life assessment, Educational Intervention, Fitness testing | Canadian Cancer Trials Group, Survivorship Research Group, Queen's University, Belfast, Other, Other, Other | 18 Years - N/A | N/A | Interventional | RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical fitness, psychological well-being and the quality of life of patients who have undergone surgery and chemotherapy for colon cancer. It is not yet known whether giving a physical activity program together with health education materials is more effective than giving health education materials alone for patients who have undergone colon cancer treatment. PURPOSE: This randomized phase III trial is studying a physical activity program given together with health education materials to see how well it works compared with giving health education materials alone for patients who have undergone treatment for high-risk stage II or stage III colon cancer. |
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