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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | A Study of CK-1827452 Infusion in Stable Heart Failure | Completed | Heart Failure | Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug, Drug - CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, CK-1827452, Placebo, Placebo, CK-1827452, Placebo, CK-1827452, CK-1827452, CK-1827452, CK-1827452 | Cytokinetics, Industry | 18 Years - N/A | Phase 2 | Interventional | This study will assess the safety, tolerability, and pharmacodynamics of CK-1827452 infusion in patients with stable heart failure. | ||
Clinicaltrials.gov | Motor Imagery Practice in Neurological Rehabilitation | Completed | Stroke, Brain Injury, Multiple Sclerosis | Behavioral, Other - Motor imagery practice, Standard physiotherapy and occupational therapy | Nuffield Orthopaedic Centre NHS Trust, Oxford Brookes University, Other, Other | 18 Years - N/A | Phase 2 | Interventional | Motor imagery is a technique widely used in learning skills. Its effectiveness has been proven in various sports and in musicians. A recent review (Braun et al. 2006) suggested that this technique may also be effective in rehabilitation of patients with neurological disease or damage, but that further research was needed. The main purpose of this research is to discover whether motor imagery practice is beneficial in the rehabilitation of skills in patients who have some disability due to neurological disease or damage. The principal research question is: are physiotherapy and occupational therapy given incorporating motor imagery more effective than standard care (i.e., the same therapies but without integrated motor imagery) in re-training task specific performance for patients with neurological disease or damage? | ||
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Clinicaltrials.gov | The Effects of Carperitide on Short and Long-term Prognosis in Patients With Both Cardiac and Renal Failure | Terminated | Heart Failure, Renal Failure | Drug, Drug - Carperitide heart failure therapy, Standard heart failure therapy | Nara Medical University, Other | 20 Years - 80 Years | Phase 4 | Interventional | Carperitide (alpha-human atrial natriuretic peptide) improves systemic hemodynamics in patients with heart failure through a vasodilatory action, a natriuretic action, and inhibition of the renin-angiotensin-aldosterone system and has been widely-used in Japan. However, a paucity of report is available on the effects of carperitide on short and long-term prognosis in patients with both cardiac and renal failure. The purpose of this study is to evaluate the effects of carperitide therapy on short and long-term prognosis in patients with both cardiac and renal failure, in comparison with standard therapy. | ||
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Clinicaltrials.gov | Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure | Terminated | Mitral Valve Insufficiency, Heart Failure | Procedure, Drug - Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT) | Duke University, National Heart, Lung, and Blood Institute (NHLBI), Heart Failure Clinical Research Network, Other, NIH, Other | 18 Years - N/A | Phase 3 | Interventional | Mitral regurgitation (MR), also known as mitral insufficiency, is a condition in which the heart's mitral valve, located between two of the heart's main chambers, does not firmly shut, allowing blood to leak backwards within the heart. Improper functioning of the mitral valve disrupts the proper flow of blood through the body, resulting in shortness of breath and fatigue. When mild, MR may not pose a significant danger to a person's health, but severe MR may be associated with serious complications, such as heart failure, irregular heart rhythm, and high blood pressure. Although there are treatments for MR, including medication and surgery, more information is needed on the effectiveness of these treatments in people with significant MR. This study will compare the safety and effectiveness of corrective surgery added to optimal medical treatment (OMT) versus OMT alone in treating people with significant MR caused by an enlarged heart. | ||
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Clinicaltrials.gov | Strategies for Aggressive Central Afterload Reduction in Patients With Heart Failure | Completed | Heart Failure | Device - SphygmoCor | Mayo Clinic, AtCor Medical, Inc., Other, Industry | 18 Years - N/A | N/A | Interventional | Heart failure (HF) is the leading cause of hospitalization among Americans over the age of 65 years, affecting greater than 5 million in the U.S. alone. Significant improvements in morbidity and mortality have been achieved through the use of medications that antagonize adverse neurohormonal signaling pathways, particularly therapies that reduce left ventricular (LV) afterload. Vascular stiffness increases with aging, contributing to the increase in cardiac load. One important repercussion of such stiffening is an increase in pulse wave velocity. As the incident pressure wave generated by cardiac ejection encounters zones of impedance mismatch (such as arterial bifurcations), part of the wave is reflected backward, summing with the incident wave, increasing central blood pressure (CBP). With normal aging, hypertension, and heart failure, increased wave velocity causes the reflected wave to reach the heart earlier, in mid to late systole, considerably increasing late-systolic load, impairing cardiac ejection, and diastolic relaxation in the ensuing cardiac cycle. The magnitude of this reflected pressure wave can be quantified by the augmentation index (AIx). The use of vasoactive agents which antagonize this increase in late systolic load (and AIx) may prove useful in the treatment of heart failure, by facilitating cardiac ejection during late systole when reflected pressure waves predominate. However, it has never been conclusively shown in humans that CBP-targeted therapy is useful in the management of HF. LV afterload, measured centrally in the ascending aorta, may differ considerably from brachial cuff-measured pressure, and has traditionally required invasive hemodynamic assessment to determine, limiting the applicability of techniques targeting CBP and late-systolic load. Recently, a novel, hand-held tonometer (SphygmoCor, Atcor Medical) has been developed for the noninvasive assessment of CBP. This pencil-like device is applied over the radial artery, and uses a validated mathematical transformation to derive central aortic pressure. This device has received FDA approval for clinical use in the assessment of central pressures. However, it remains unknown whether knowledge of CBP and late-systolic load (AIx) confers any clinically-significant incremental benefit in the management of patients with heart failure. The primary objective of the proposed investigation will be to determine if this assessment might have such a role. | ||
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Clinicaltrials.gov | Treatment of Dysphagia Using the Mendelsohn Maneuver | Completed | Stroke, Dysphagia | Behavioral - Mendelsohn Maneuver | University of Arkansas, National Institute on Deafness and Other Communication Disorders (NIDCD), Other, NIH | 21 Years - N/A | Phase 1/Phase 2 | Interventional | The primary goal of the investigation is to determine the effects of the Mendelsohn maneuver on the physiology of the swallow in individuals who have suffered a stroke and exhibit signs of pharyngeal dysphagia. | ||
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Clinicaltrials.gov | Jarvik 2000 Heart as a Bridge to Cardiac Transplantation - Pivotal Trial | Completed | Heart Failure | Device - The Jarvik 2000 Ventricular Assist System | Jarvik Heart, Inc., Industry | 18 Years - N/A | Phase 2/Phase 3 | Interventional | The purpose of the study is to determine the safety and effectiveness of the Jarvik 2000 Heart as a bridge to heart transplantation in end-stage heart failure patients who are approved heart transplant candidates. | ||
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Clinicaltrials.gov | Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) | Completed | Vertebrobasilar Insufficiency, Ischemic Attack, Transient, Cerebrovascular Disorder, Brain Ischemia, Stroke | Sepideh Amin-Hanjani, National Institute of Neurological Disorders and Stroke (NINDS), Other, NIH | 18 Years - N/A | Observational | Patients with blockage of the blood vessels that supply blood to the back of the brain, known as vertebrobasilar disease (VBD), are at risk of having a stroke or temporary symptoms of a stroke known as transient ischemic attack (TIA). The risk of repeated stroke associated with VBD may be affected by several risk factors, including the degree to which the blockage reduces the blood flow to the brain. Patients with VBD have different levels of blockage ranging from partial blockage to complete blockage, which can affect the blood flow to the brain by variable amounts. The purpose of this research is to determine if patients with symptomatic VBD who demonstrate low blood flow to the back of the brain on magnetic resonance (MR)imaging are at higher risk of developing another stroke or TIA than patients with normal blood flow. | ||||
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Clinicaltrials.gov | Extending Acute Stroke Trials to the Aerial Inter-hospital Transfer Setting | Completed | Stroke | Drug, Drug, Other, Other - Ranitidine, Placebo, Advanced notification, No advanced notification | University of Iowa, Other | 18 Years - N/A | N/A | Interventional | We are inviting patients who have been diagnosed with an ischemic or hemorrhagic stroke and are being transferred by Air Care helicopters to the University of Iowa Hospitals and Clinics (UIHC) for further care to participate in this research study to test the following: 1) To test whether it is possible to go through all the procedures necessary to start a study, including an informed consent, before the patient is transferred by helicopter to Iowa City. 2)To test a low risk medication called, Ranitidine, that might lower the chances of developing chemical pneumonitis (irritation of the lungs by stomach contents), a fairly common complication in patients that have had a stroke. Patients will be randomly assigned to receive a single dose injection of either Ranitidine (50 milligrams (mg)) or placebo (normal saline). | ||
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Clinicaltrials.gov | Assessment of Cardiac Functional Reserve in Heart Failure With Preserved Ejection Fraction (HF-PEF) | Completed | Heart Failure | University of Wisconsin, Madison, Other | 18 Years - N/A | Observational | This study will compare the ability of the heart to increase its contractile performance during stress in patients with a history of heart failure without systolic dysfunction and in controls. | ||||
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Clinicaltrials.gov | Harefield Recovery Protocol Study for Patients With Refractory Chronic Heart Failure | Terminated | Heart Failure, Dilated Cardiomyopathy | Drug - clenbuterol | Francis D. Pagani, Georgetown University, Montefiore Medical Center, Northwestern University, Ohio State University, Texas Heart Institute, University of Minnesota, University of Pennsylvania, Thoratec Corporation, Other, Other, Other, Other, Other, Other, Other, Other, Industry | 18 Years - N/A | Phase 1 | Interventional | The purpose of this study is to evaluate whether patients with chronic heart failure not due to coronary artery disease who require use of a left ventricular assist device (LVAD) for refractory heart failure can recover sufficient heart function to allow the pump to be explanted. The study aims to avoid the need for transplantation in these patients by using standard heart failure medications to reduce the size of the left ventricle and then using the investigational drug, clenbuterol, to further improve left ventricular function. | ||
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Clinicaltrials.gov | The Development of Tolerance to α1-Adrenoceptor Blockade With Chronic Carvedilol Treatment | Completed | Heart Failure | Drug - phenylephrine | University of Utah, Other | 18 Years - 85 Years | N/A | Interventional | There is now strong evidence from clinical trials that carvedilol therapy in heart failure is superior to therapy with metoprolol. Not only does carvedilol have superior effects on lipid profiles, insulin sensitivity, renal blood flow, and reversal of pathologic remodeling but also its use is associated with fewer deaths compared to metoprolol. These facts make it important to carefully define how metoprolol and carvedilol are pharmacologically different. One potential difference is α1-AR antagonism. If we demonstrate that these α1-AR effects are preserved with chronic therapy, then α1-AR blockade may have an important role in carvedilol favorably altering the natural history of heart failure. On the other hand, if we demonstrate that tolerance to the α1-AR blockade effect of carvedilol decreases with time, then it would be unlikely that this pharmacologic property contributes to the efficacy of carvedilol. In such a case other pharmacologic properties, such as antioxidant activity, would appear to be important. These results will help guide future studies into CHF and AR blockade. | ||
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Clinicaltrials.gov | Assess Safety and Probable Benefit of the EXCOR® Pediatric Ventricular Assist Device | Completed | Heart Failure, Cardiomyopathies | Device - EXCOR Pediatric | Berlin Heart, Inc, Industry | N/A - 16 Years | N/A | Interventional | The purpose of the study is to determine whether use of the Berlin Heart EXCOR® Pediatric Ventricular Assist Device for bridge-to-transplant is associated with a reasonable assurance of safety and probable benefit such that the EXCOR® Pediatric merits approval by the Food and Drug Administration under a Humanitarian Device Exception (HDE). | ||
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Clinicaltrials.gov | Levels of Inflammatory Markers in the Treatment of Stroke-An SPS3 Ancillary Study | Completed | Hypertension, Stroke | Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Other, NIH | 30 Years - N/A | Observational | The goals of this trial are to determine the prognostic significance of an elevated level of inflammatory blood markers in people who have experienced small subcortical strokes and who are enrolled in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial. | ||||
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Clinicaltrials.gov | Evaluation of the Effect of Dextro-Amphetamin Added to Physiotherapy in Patients After Stroke | Terminated | Stroke | Drug, Other - Dextro-Amphetamin, Glucose | Reha Rheinfelden, Other | 18 Years - N/A | Phase 4 | Interventional | The aim of the study is to evaluate the effect of Dextro-amphetamin added to physiotherapy on motor recovery in patients after stroke. The study is a double-blinded placebo-controlled randomised controlled trial. Patients after a first-ever ischemic stroke will receive Dexamphetamine (10mg) twice per week for a duration of five weeks after a baseline phase of two weeks. The outcome measure focuses on motor recovery and will be assessed: - one and two weeks before study intervention (baseline phase) - five times during the study intervention - one week after study intervention (follow-up) - once after six and twelve months after start of the study intervention (follow-up). | ||
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Clinicaltrials.gov | Development of a Web-Based Course to Maintain Skills in Nurses Trained to Screen for Dysphagia | Completed | Deglutition Disorders, Dysphagia, Stroke | Other - TOR-BSST© Refresher Training | University Health Network, Toronto, Ontario Ministry of Health and Long Term Care, Other, Other | N/A - N/A | N/A | Interventional | This research aims to facilitate the successful implementation of the new Heart and Stroke Foundation of Ontario dysphagia screening model for acute stroke patients. The objectives will be 1) to determine the natural history of dysphagia screening skill decay, and 2) to assess the benefit of independent web-based practice and periodic feedback on screening skill maintenance. We will enrol a convenience sample of nurses who currently work with stroke patients but who have had no prior formal training with dysphagia screening. The study will consist of 2 phases: A) an initial pilot phase followed by B) a prospective randomized controlled study. During Phase A, three new web-based, self-instructed skill refresher courses will be developed to help nurses maintain the skills they will learn in an 8-hour workshop on dysphagia screening. During Phase B, nurses will receive the 8-hour workshop and one-on-one evaluation by a speech-language pathologist (SLP). Following training, competent screeners will be randomized into one of two groups: Group A - Control group with no refresher course or periodic feedback from SLP; Group B - Web-based skill refresher courses only. Nurses will be evaluated at several timepoints throughout Phase B to assess theoretical dysphagia screening knowledge and skills. | ||
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Clinicaltrials.gov | Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases | Unknown status | Stroke | Drug, Drug - Chinese herbs formula, Mannitol | Nanjing University of Traditional Chinese Medicine, Other | 40 Years - 75 Years | Phase 2 | Interventional | The purpose of this study is to determine whether the Chinese herbs formula is effective in the treatment of hemorrhagic stroke and to find out Chinese pathogeny and pathogenesis in the disease. | ||
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Clinicaltrials.gov | Treatments for Recovery of Hand Function in Acute Stroke Survivors | Completed | Stroke, Acute, Stroke, Hemiparesis, Hemiplegia | Device - Neuromuscular electrical stimulator | MetroHealth Medical Center, Case Western Reserve University, National Institutes of Health (NIH), Other, Other, NIH | 18 Years - 80 Years | Phase 1/Phase 2 | Interventional | Impaired hand function is one of the most frequently persisting consequences of stroke. The purpose of this study is to investigate whether two different types of treatment improve recovery of hand function after stroke. | ||
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Clinicaltrials.gov | Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk | Terminated | Atrial Fibrillation, Atrial Flutter, Stroke, Embolism, Systemic Arterial, Major Bleeding | Drug, Drug - Home Monitoring Guided OAC, Physician-Directed OAC | Biotronik, Inc., Industry | 18 Years - N/A | Phase 4 | Interventional | The IMPACT Study will investigate the potential clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) technology and a predefined anticoagulation plan compared to conventional device evaluation and physician-directed anticoagulation in patients with implanted dual-chamber defibrillators or cardiac resynchronization therapy devices. | ||
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Clinicaltrials.gov | Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant | Unknown status | Acromegaly, Heart Failure, Hypertrophy, Left Ventricular | Drug - pegvisomant | University of Wuerzburg, Pfizer, Other, Industry | 18 Years - N/A | Phase 4 | Interventional | The purpose of this study is to evaluate changes in left ventricular mass and cardiac function in patients with active acromegaly before and after treatment with the growth hormone receptor antagonist pegvisomant for one year. |
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