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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Spatz3 Adjustable Balloon System® (Spatz3) Post Approval Study | Enrolling by invitation | Obesity | Spatz FGIA, Inc, Other | 22 Years - 65 Years | Observational [Patient Registry] | A prospective, Multicenter open-label post approval trial for adults with a Body Mass Index (BMI) of 35.0-40.0 kg/m2 or a BMI of 30.0 to 34.9 kg/m2 with one or more major obesity-related comorbid conditions who have failed to achieve and maintain weight-loss with a supervised weight control program. The study aims to demonstrate that the safety of the device in the post market setting is comparable to what was observed in the US pivotal study. | ||||
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Clinicaltrials.gov | The Effect of SHR20004（Noiiglutide ） on Body Weight in Obese Subjects Without Diabetes | Enrolling by invitation | Obesity | Drug, Drug, Drug, Drug - SHR20004, SHR20004, SHR20004, placebo | Jiangsu HengRui Medicine Co., Ltd., Industry | 18 Years - 65 Years | Phase 2 | Interventional | The study is being conducted to assess the efficacy and safety of SHR20004 on body weight in obese subjects without diabetes. | ||
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Clinicaltrials.gov | Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea | Enrolling by invitation | Obstructive Sleep Apnea, Obesity | Procedure - sleeve gastectomy | Brandon Nokes, Other | 30 Years - 65 Years | Observational | Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechanistic drivers between obesity and obstructive sleep apnea. | |||
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Clinicaltrials.gov | ObeSity and Jobs in SoCioeconomically Disadvantaged CommUnities: A Randomized CLinical Precision Public HealTh Intervention --The SCULPT-Job Study | Enrolling by invitation | Weight Maintenance, Weight Loss, Stress, Psychological, Job Stress, Diabetes Prevention, Obesity, Cardiovascular Risk Factor, Cardiovascular Diseases | Behavioral, Behavioral - Diabetes Prevention Program + Job and Legal Services, Diabetes Prevention Program | University of California, San Francisco, American Heart Association, Other, Other | 18 Years - N/A | N/A | Interventional | This is an interventional research study about clinical, psychosocial, and behavioral factors that impact weight loss, weight maintenance, and cardiovascular disease in socially disadvantaged persons. | ||
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Clinicaltrials.gov | Time Restricted Eating for Weight Management | Enrolling by invitation | Obesity, PreDiabetes | Other, Other - 8-hour Time restricted eating, Calorie restriction | University of Illinois at Chicago, Other | 18 Years - 70 Years | N/A | Interventional | Approximately 26% of Americans have obesity and prediabetes. These conditions greatly increase the risk for the development of type 2 diabetes. Innovative lifestyle strategies to treat obesity and prediabetes are critically needed. If the aims of this application are achieved, this study will be the first to show that time restricted feeding can be implemented as an alternative to traditional dieting (i.e. daily calorie restriction) for long-term weight management. This study will also show that time restricted feeding can be used as an effective non-pharmacological therapy to improve insulin sensitivity and decrease metabolic risk in this population group. | ||
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Clinicaltrials.gov | PATHWEIGH: Pragmatic Weight Management in Primary Care | Enrolling by invitation | Obesity | Other, Other - Weight management care path, Control | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Other, NIH | 18 Years - 89 Years | N/A | Interventional | The study examines patient weight loss and maintenance, associated predictors (patient health characteristics and demographics), and contextual factors in the practice environment that influence the intervention's adoption, implementation, and sustainability. This will be achieved through a mixed methods implementation study including collection and analysis of de-identified clinical data, surveys, observations, and interviews. | ||
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Clinicaltrials.gov | RESILIENCE: Personalizing Cardiovascular Health | Enrolling by invitation | Obesity, Cardiovascular Risk Factor | Behavioral - Digital weight loss intervention | Duke University, Other | 40 Years - 75 Years | N/A | Interventional | Obesity is a rapidly growing epidemic that is associated with the development of cardiovascular disease (CVD). However, some individuals with obesity appear to be resistant to CVD, and other individuals demonstrate resilience to obesity and CVD risk factors. The investigator's overall objective is to understand factors contributing to the heterogeneity of CVD resistance and resilience among individuals with obesity at Duke. | ||
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Clinicaltrials.gov | Modifiable Predictors of Neural Vulnerabilities for Obesity | Enrolling by invitation | Obesity | Other - Milkshake fMRI | University of Nebraska Lincoln, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Nebraska, The University of Texas at San Antonio, Stanford University, Other, NIH, Other, Other, Other | 19 Years - N/A | N/A | Interventional | The purpose of this study is to examine how certain factors in childhood and adolescence relate to neural vulnerabilities for obesity in young adulthood. It is hypothesized that specific individual and environmental factors will significantly predict neural vulnerabilities for obesity. | ||
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Clinicaltrials.gov | Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol | Enrolling by invitation | Obesity, Bariatric Surgery, Roux-en Y Gastric Bypass | Procedure, Drug, Procedure, Drug, Drug, Drug, Other - Digestive biopsy, Carvedilol 25mg, Serial blood sampling for PK analysis, Metoprolol 100 mg for CYP2D6 phenotyping, Simvastatin 40mg, Midazolam 2 mg for CYP3A4 phenotyping, Genotyping | Natalia Valadares de Moraes, Fundação de Amparo à Pesquisa do Estado de São Paulo, University of Sao Paulo, Other, Other, Other | 18 Years - 65 Years | Phase 4 | Interventional | Obesity affects more than 1 in 3 adults in the U.S. It is commonly associated with reduced quality of life and complications such as metabolic syndrome, heart disease, high blood pressure and sleep disorders. The gastric bypass, also known as Roux-en-Y gastric bypass (RYGB), is one of the most common weight-loss surgeries due to the reliable and long-lasting weight loss and the effective remission of obesity-associated conditions. Although the impact of obesity on absorption, distribution, metabolism and excretion has been documented for several drugs, label recommendations might not account for specific population subgroups, specially morbidly obese patients and obese patients post-bariatric surgery. This study aims to investigate the impact of obesity and RYGB surgery on the kinetic disposition of simvastatin (Study A) and carvedilol (Study B). | ||
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Clinicaltrials.gov | Development of Obesity and Bariatric Surgery | Enrolling by invitation | Obesity | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Other | 18 Years - 75 Years | Observational | This study focus on the cause of obesity and impacts of bariatric surgery on it. | ||||
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Clinicaltrials.gov | Weight Loss Effects of M-health App in Obesity Multidisciplinary Outpatient Clinic | Enrolling by invitation | Obesity, m-Health, NAFLD | Device, Other - m-Health app, conventional outpatient obesity management | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Other | 18 Years - 65 Years | N/A | Interventional | This is a randomized, open, controlled, single-center trial to identify the weight loss effects of adding mobile health application in obesity multidisciplinary outpatient clinic. | ||
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Clinicaltrials.gov | Body Weight Response With Disulfiram in Humans | Enrolling by invitation | Obesity, Drug | Drug - Disulfiram 250 mg | Universidad de Guanajuato, Laboratorios Doctor Macías, Other, Other | 18 Years - 65 Years | Early Phase 1 | Interventional | Overweight and obesity due to food that exceeds the requirements is an increasingly common global problem. Lifestyle intervention and anorectic drugs result in minimal weight loss, which tends to be easily regained. In addition, drugs tend to have too many side effects and have had to be withdrawn from management schemes and even from the market. Disulfiram (Antabuse®️) is approved by the Food and Drug Administration against chronic alcohol addiction. In a mouse study, disulfiram prevented body weight gain and negated the adverse impact of an obesogenic diet on insulin; used properly it is a safe drug. Carrying out a testing-concept study with disulfiram will allow the establishment of guidelines on clinical studies focused on its use as an adjunct in the reduction and control of body weight. | ||
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Clinicaltrials.gov | A Virtual Cardiometabolic Health Program for African Immigrants: The Afro-DPP Program | Enrolling by invitation | Diabetes Mellitus, Diabetes Mellitus, Type 2, PreDiabetes, Hypertension, High Blood Pressure, High Blood Sugar, Obesity, Overweight, Overweight and Obesity, Overweight or Obesity | Behavioral - The Diabetes Prevention Program | Johns Hopkins University, National Institute of Nursing Research (NINR), Other, NIH | 25 Years - 75 Years | N/A | Interventional | A pilot study titled "A Virtual Cardiometabolic Health Program for African Immigrants (The Afro-DPP Program) will be conducted to address the cardiometabolic of community-dwelling African immigrants who have multiple cardiometabolic risk factors including hypertension, Type 2 Diabetes, high cholesterol, and overweight/obesity. The proposed study will recruit a total of 60 participants and will use a non-equivalent control group design to test the effectiveness of the intervention at two African churches in the Baltimore, Washington, D.C. area. The two churches will be randomly assigned to the intervention or delayed intervention group. At the end of a 6-month follow-up period, the control church will receive the intervention (delayed control group). All participants will receive a Bluetooth-enabled digital scale (Omron Model: BCM-500) that measures body composition including Body Weight, Body Fat percentage, Visceral Fat, Skeletal Muscle percentage, Resting Metabolism and Body Mass Index. A Bluetooth-enabled blood pressure monitor (Omron Model: BP7250) will also be distributed to all participants. All participants will download the Omron Connect app which will allow the participants to sync participants' blood pressure readings and body composition readings into the app. The research team will access these readings to monitor study outcomes and participants progress during the follow-up period. | ||
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Clinicaltrials.gov | Evaluating Benefit of Peptide Based Diet in Obese HEN Patients | Enrolling by invitation | Obesity | Dietary Supplement - Peptamen Intense VHP, Nestlé Health Science, Switzerland | Mayo Clinic, Other | 18 Years - N/A | N/A | Interventional | The purpose of this study is to assess the effects of a low energy, high protein tube feeding formula on body weight in tube fed patients who are obese. It will also assess study formula tolerance as well as impact of the study formula on lean body mass, blood pressure, blood sugar and lipids. | ||
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Clinicaltrials.gov | Alternate Day Fasting Combined and NAFLD for the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) | Enrolling by invitation | Non-Alcoholic Fatty Liver Disease, Obesity, Pre-diabetes | Other, Other - Alternate day fasting, Exercise | University of Illinois at Chicago, Other | 18 Years - 65 Years | N/A | Interventional | Approximately 65% of obese individuals have non-alcoholic fatty liver disease (NAFLD), and this condition is strongly related to the development of insulin resistance and diabetes. Innovative lifestyle strategies to treat NAFLD are critically needed. The proposed research will demonstrate that alternate day fasting (ADF) combined with exercise is an effective non-pharmacological therapy to help obese prediabetic individuals with NAFLD reduce fatty liver and prevent progression of prediabetes to diabetes. | ||
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Clinicaltrials.gov | Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy | Enrolling by invitation | GERD, Obesity | Procedure, Procedure - Endoscopy, Surgery | Johns Hopkins University, Other | 18 Years - 75 Years | Observational | GERD is common in the obese population. Bariatric procedures are the mainstay of therapy for these patients. Bariatric procedures can be surgical (Roux-en-Y gastric bypass and Vertical sleeve gastrectomy) or endoscopic (endoscopic sleeve gastroplasty). The rate of GERD after either treatment is unknown as is the rate of silent reflux. The study primary objective is to assess the incidence rate of GERD in bariatric patients that undergo either therapy. | |||
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Clinicaltrials.gov | Low Calorie Diet and Diabetes | Enrolling by invitation | Diabetes Mellitus Type 2, Dyslipidemia, Non-alcoholic Fatty Liver Disease, Obesity | Behavioral - Low calorie diet followed by life style intervention | Karolinska University Hospital, Other | 18 Years - 65 Years | N/A | Interventional | The primary hypothesis is to investigate whether a low calorie diet for 7 weeks followed by continuous lifestyle advice is an effective option to achieve an improvement in glucose control as measured by HbA1c after 52 and 104 weeks as compared to baseline values in obese type 2 diabetes patients on either tablet or insulin treatment. The secondary hypothesis is to investigate whether the weight reduction therapy also has significant impact on various anthropometric, clinical and metabolic parameters associated with obesity. | ||
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Clinicaltrials.gov | Gut Microbiota, Short Chain Fatty Acids, and Adiposity Across The Epidemiological Transition | Enrolling by invitation | Obesity, Diabetes | Behavioral - Diet and physical activity monitoring | Loyola University, Other | 18 Years - 50 Years | Observational | The objective of this study is to define associations between gut microbiota, SCFAs and obesity in populations spanning the epidemiologic transition, and explore mechanisms by which these factors may independently and collectively influence the development of obesity. The central hypothesis of this study is that the composition of gut microbiota drives SCFA production which in turn influences obesity risk at the population-level. | |||
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Clinicaltrials.gov | Białystok PLUS - Polish Longitudinal University Study | Enrolling by invitation | Cardiovascular Diseases, Diabetes, Neuro-Degenerative Disease, Obesity, Pulmonary Disease, Neoplastic Disease | Other - Discovering novel risk factors. | Medical University of Bialystok, University Medicine Greifswald, City of Białystok, Marshall's Office of Podlaskie Voivodship, Other, Other, Other, Other | 20 Years - 80 Years | Observational | The main goal of the study is to provide a unique multidimensional picture of the health of the population with simultaneous optimal standards of sampling, processing and storing of data and biomaterial that will allow discovering novel mechanisms in the development and progression of common civilization diseases. In the effect it will improve prevention, diagnosis and treatment. | |||
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Clinicaltrials.gov | In Market Utilisation of Liraglutide Used for Weight Management in the UK: a Study in the CPRD Primary Care Database | Enrolling by invitation | Obesity, Overweight | Drug - Liraglutide | Novo Nordisk A/S, Industry | N/A - N/A | Observational | This study is conducted in Europe. The aim of this study is to investigate the usage of liraglutide for weight management in clinical practice using the CPRD (Clinical Practice Research Datalink) primary care database. |
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