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Integrated Clinical Trials is a virtual database currently indexing clinical trials from: EU Clinical Trials Register and ClinicalTrials.gov.
(last updated: Nov 28, 2022)
Clinical Trials Information| Database | Title | Recruitment | Conditions | Intervention | Sponsored By | Gender | |||||
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Clinicaltrials.gov | Peking University Birth Cohort in Tongzhou | Active, not recruiting | Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension, Preterm Birth, Obesity, Mother-Infant Interaction, Child Development, Anemia | Other - No intervention | Peking University, National Natural Science Foundation of China, Other, Other | Female | 18 Years - 49 Years | Observational | The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to 6 years old. Biological samples including blood and tissue samples are also collected from mothers and their children. | ||
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Clinicaltrials.gov | The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children | Active, not recruiting | Obesity, Overweight, Type 1 Diabetes Mellitus | Other - No intervention | University of California, San Diego, Other | 7 Years - 17 Years | Observational | This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D). | |||
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Clinicaltrials.gov | Tongzhou Cohort Study | Recruiting | Obesity, Hypertension | Other - No intervention | Beijing Friendship Hospital, Beijing Tongzhou Yongshun Community Health Service, Other, Other | 60 Years - N/A | Observational | The present study aimed to investigate the impact of obesity on long-term cardiovascular risk in elderly patients with hypertension. | |||
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Clinicaltrials.gov | Prevalence of Protein-energy Wasting and Obesity Among Danish Dialysis Patients | Completed | Undernutrition, Renal Insufficiency, Chronic, Obesity | Other - No intervention | Zealand University Hospital, Other | 18 Years - N/A | Observational | The purpose of this study is to determine the prevalence of protein-energy wasting and obesity among Danish dialysis patients. | |||
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Clinicaltrials.gov | Mode of Action of Topiramate in the Treatment of Obese Patients With and Without Type 2 Diabetes Mellitus | Completed | Obesity, Diabetes Mellitus Type 2 | Other - No intervention | Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Industry | 18 Years - 75 Years | Observational | The purpose of this study is to explore the mode of action of topiramate in the treatment of obese and diabetic patients by testing association between genetic variations within candidate genes or chromosomes (thread like structure found in cell which carries genes) and the clinical outcomes. | |||
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Clinicaltrials.gov | Activity, Adiposity, and Appetite in Adolescents 2 | Withdrawn | Obesity, Metabolic Disease, Insulin Sensitivity | Other - No intervention | Children's Mercy Hospital Kansas City, Other | 14 Years - 17 Years | Observational | Our goal is to examine linkages between physical activity, appetite control, and energy metabolism in adolescents. We will assess metabolic function and appetite control in male and female adolescents stratified by bodyweight and physical activity using across-sectional study design. | |||
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Clinicaltrials.gov | Adult Weight, Genetics and Lifestyle Factors | Completed | Obesity | Other - No intervention | St Mary's University College, Other | Female | 18 Years - 65 Years | Observational | Childhood obesity leads to adulthood obesity, demonstrated in many retrospective and longitudinal studies. Genetics as a predictor of obesity is less established. Morandi et al, (2012) assessed whether lifestyle and genetic factors can be used to predict childhood obesity, concluding that genetics had minimal predictive effect. More recently Seyednasrollah, (2017) demonstrated that genetic information, when alongside clinical factors for cardiovascular disease, increased the predictive accuracy of obesity risk in adults. This study aims to investigate if known lifestyle and genetic risk factors are associated with BMI and if they can be used as predictors of overweight/obesity in adults. | ||
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Clinicaltrials.gov | Beijing Children and Adolescents Metabolic Syndrome Study (BCAMS Study) | Completed | Obesity, Metabolic Disease | Other - No intervention | Peking Union Medical College Hospital, Capital Institute of Pediatrics, China, Beijing Chao Yang Hospital, Other, Other, Other | 6 Years - 18 Years | Observational [Patient Registry] | Base on enriched resources from the Metabolic Syndrome cohort in children, a long-term prospective cohort study will be carried out. This cohort is a unique biochemical and genetic database of Chinese population with large number of subjects in the world. By collecting information of disease history and lifestyle, measuring clinical and metabolic parameters, especially biomarkers which can reflect the underlying mechanism of insulin resistance and metabolic syndrome, we intend to sort out some unique biochemical and genetic markers for Chinese population. | |||
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Clinicaltrials.gov | The Impact of Misclassification of Obesity by Body Mass Index on Mortality in Patients With Chronic Kidney Disease | Completed | Chronic Kidney Diseases, Obesity | Other - No intervention | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Other | 18 Years - 90 Years | Observational | Unlike the general population, a higher body mass index (BMI) is associated with greater survival among patients with chronic kidney disease (CKD). However, obesity is defined as excess body fat that associated with clearly elevated health risks according to the World Health Organization. In addition, muscle wasting is prevalent among CKD subjects. Thus, we hypothesized that different definition of obesity, based on BMI or body fat percentage, might have different impact on clinical outcomes among CKD population. | |||
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Clinicaltrials.gov | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity | Recruiting | Overweight and Obesity, Overweight or Obesity, Obesity, Obesity, Morbid, Obesity, Abdominal, Obesity, Familial, Obesity, Endocrine, Obesity, Visceral, Obesity Hypoventilation Syndrome | Other - No intervention | ProgenaBiome, Other | 18 Years - N/A | Observational [Patient Registry] | This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding obesity. | |||
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Clinicaltrials.gov | Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals | Recruiting | Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor | Other - No intervention | Loughborough University, Other | 18 Years - 40 Years | Observational | This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese. Blood and white adipose tissue samples will be collected in the fasted state to assess inflammatory status. There is evidence to suggest that markers of inflammation in the blood and white adipose tissue increase with increasing levels of obesity. However, the white adipose tissue total protein content and phosphorylation of proteins involved in inflammatory pathways has not previously been compared between lean and obese individuals. The investigators hypothesise that obese individuals will have increased levels of inflammation in the blood and white adipose tissue, compared to their lean counterparts. | |||
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Clinicaltrials.gov | CD36 and Human Fat Taste Perception | Completed | Obesity | Other - No intervention | Washington University School of Medicine, Monell Chemical Senses Center, Other, Other | 21 Years - 50 Years | Observational | The purpose of this study is to determine the effect of common human variants in in taste related genes, such as CD36 gene, a putative fat taste receptor, affect fat taste perception. | |||
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Clinicaltrials.gov | Comparison Between Patients With or Without Diabetes Recovery After Bariatric Surgery | Completed | Diabetes, Bariatric Surgery, Obesity | Other - No intervention | University of Campinas, Brazil, Fundação de Amparo à Pesquisa do Estado de São Paulo, Other, Other | 18 Years - 60 Years | Observational | Bariatric surgery can lead to improvement or even resolution of type 2 diabetes in about 80% of patients submitted to Roux-en-Y gastric bypass (RYGP). Otherwise, many patients experienced no resolution of their diabetes despite massive surgical-induced weight loss. There appears to be a variable response to surgery depending on surgical and patient factors. To explore potential factors affecting diabetes outcomes after RYGP, this study is proposed to make a description of effects of surgical procedures on incretin, insulin production and sensitivity and a comparison between patients with or without remission of Type 2 Diabetes. | |||
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Clinicaltrials.gov | Maternal Body Composition Regulates Placental Function | Completed | Obesity, Pregnancy | Other - No intervention | National Center for Research Resources (NCRR), Oregon Health and Science University, NIH, Other | Female | 18 Years - N/A | Observational | This study examined the relationships between maternal body composition, placental function, and fetal nutrition and body composition, and sought to determine the most accurate method of maternal body composition analysis in late pregnancy. | ||
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Clinicaltrials.gov | Melanocortin 4 Receptor Mutations and Obesity-associated Diseases | Completed | Obesity | Other - No intervention | University of Copenhagen, Rhythm Pharmaceuticals, Inc., Other, Industry | 18 Years - 70 Years | Observational | Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity. Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity. The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure. | |||
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Clinicaltrials.gov | No-worry Baby Project | Recruiting | Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity, Anemia in Pregnancy, Complications, Pregnancy, Depression, Obstetric Labor Complications, Asthma, Allergic Disorder, Immune System Diseases, Neurodevelopmental Disorders, Reproductive Disorder | Other - No intervention | Sun Yat-sen University, Huizhou No.1 Maternal and Child Care Service Cencer, Other, Other | Female | 18 Years - 49 Years | Observational | The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China. | ||
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Clinicaltrials.gov | The Netherlands Epidemiology of Obesity Study | Active, not recruiting | Obesity | Other - No intervention | Leiden University Medical Center, Other | 45 Years - 65 Years | Observational | The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort study in 6671 men and women aged 45 to 65 years, with an oversampling of individuals with a BMI of 27 kg/m2 or higher. The NEO study is designed to investigate pathways that lead to common diseases and conditions. Men and women aged between 45 and 65 years with a self-reported BMI of 27 kg/m2 or higher living in the greater area of Leiden, the Netherlands, were eligible to participate in the NEO study. Participants were recruited via three recruitment strategies. First, participants were recruited by general practitioners in the area of Leiden, in the West of The Netherlands. Second, participants were recruited through advertisements in local newspapers and through posters distributed in public areas of Leiden and surroundings. Third, participants were recruited via the registries of three municipalities surrounding Leiden (Katwijk, Leiderdorp and Teylingen). Inhabitants of Katwijk and Teylingen aged between 45 and 65 years were invited to participate if they had a self-reported BMI of 27 kg/m2 or higher. All inhabitants aged between 45 and 65 years of Leiderdorp were invited to participate irrespective of their BMI, allowing for a reference distribution of BMI. Participants were invited to a baseline visit at NEO study centre of the LUMC after an overnight fast. Prior to this study visit, participants collected their urine over 24 h and completed a general questionnaire at home to report demographic, lifestyle and clinical information. The participants were asked to bring all medication they were using to the study visit. At the baseline visit an extensive physical examination was performed, including measurements of anthropometry, blood pressure, both fasting and postprandial blood sampling (30 minutes and 2.5 hours after a liquid mixed meal), ECG, carotid artery IMT, and pulmonary function tests. In random subsets of participants MRI of abdominal fat, brain, knee, heart function, and pulse wave velocity of the aorta was performed, as well as indirect calorimetry, accelerometry combined with continuous heart rate, and total sleep time with actigraphy. Participants are followed via their general practitioners and hospital registries for the incidence of common diseases and mortality. | |||
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Clinicaltrials.gov | Neck Fat Accumulation and Its Relationship to Cardiovascular Risk and Metabolic Syndrome | Completed | Obesity | Other - No intervention | Massachusetts General Hospital, Other | 18 Years - 91 Years | Observational | Accumulation of fat in the neck using tape measures has been linked to increased cardiovascular risk. The investigators' hypothesis is that detailed measures of neck fat using computed tomography will show that specific fat compartments in the neck contribute differently to cardiovascular risk. |
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