On page 1 showing 1 ~ 20 out of 226 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain water content, Immunofluorescence, Immunohistochemistry (IHC), Mitochondrial MDA, SOD Content, Prussian Blue Staining, Reactive Oxygen Species Content, TUNEL staining, Western blot, dihydroethidium staining
Citation: Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain InjuryOxid Med Cell Longev. 2018 Aug 27;2018:4783602. doi: 10.1155\/2018\/4783602. eCollection 2018. PMC6129854
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: OF1
Assessments: Immunohistochemistry (IHC), Ventricular volume, antibody-coupled magnetic bead system, qRT-PCR
Citation: Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Oré MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B. Role of microglia in a mouse model of paediatric traumatic brain injuryBrain Behav Immun. 2017 Jul;63:197-209. doi: 10.1016\/j.bbi.2016.11.001. Epub 2016 Nov 4. PMC5441571
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J (transgenic)
Assessments: Enzyme-linked immunosorbent assay (ELISA), qRT-PCR
Citation: Febinger HY, Thomasy HE, Pavlova MN, Ringgold KM, Barf PR, George AM, Grillo JN, Bachstetter AD, Garcia JA, Cardona AE, Opp MR, Gemma C. Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injuryJ Neuroinflammation. 2015 Sep 2;12:154. doi: 10.1186\/s12974-015-0386-5. PMC4557842
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Novel object location test, Novel object recognition test, qPCR, Compound action potential (CAP) recording, Immunohistochemistry (IHC)
Citation: Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP. Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of MicrogliaJ Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523\/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19. PMC9121837
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Elevated plus maze test, Histology, Novel object recognition test, Open field test, T-Maze, Western blot, infarct volume
Citation: Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A(3) receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injuryJ Neuroinflammation. 2020 Nov 12;17(1):339. doi: 10.1186\/s12974-020-02009-7. PMC7659122
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Array image analysis, Beam walk test, Cytokine array, Immunohistochemistry (IHC), Neurological Severity Score (NSS), confocal imaging, phospho-Akt array
Citation: Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F. Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injuryInt Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016\/j.intimp.2017.08.002. Epub 2017 Aug 12.
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Western blot, optical density, qRT-PCR
Citation: Tian Y, Zhao R, Li X, Zhou J, Zhan D, Wang Y, He Y, Zhang J, Yuan H. Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in miceExp Anim. 2022 Mar 7. doi: 10.1538\/expanim.21-0148. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: PCR, Western blot
Citation: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in miceBrain Res. 2014 Oct 17;1585:13-22. doi: 10.1016\/j.brainres.2014.08.026. Epub 2014 Aug 20.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Neurological Severity Score (NSS), RT-PCR
Citation: Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNeurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016\\/j.neulet.2014.10.037. Epub 2014 Oct 28.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Hematoxylin and Eosin, Immunohistochemistry (IHC)
Citation: Feng Y, Gao Y, Wang T, Tao L, Qiu S, Zhao X. A longitudinal study of the mechanical properties of injured brain tissue in a mouse modelJ Mech Behav Biomed Mater. 2017 Jul;71:407-415. doi: 10.1016\/j.jmbbm.2017.04.008. Epub 2017 Apr 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Glasgow Coma Scale, TUNEL staining, Immunohistochemistry (IHC)
Citation: Zhaba WD, Deji QZ, Gao SQ, Han YL, Gao CC, Deng HJ, Liu XL, Li T, Zhou ML. Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injuryNeuroreport. 2021 Apr 7;32(6):472-478. doi: 10.1097\/WNR.0000000000001619.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Passive avoidance test, Neurological Severity Score (NSS), passive avoidance test
Citation: Khalin I, Jamari NL, Razak NB, Hasain ZB, Nor MA, Zainudin MH, Omar AB, Alyautdin R. A mouse model of weight-drop closed head injury: emphasis on cognitive and neurological deficiencyNeural Regen Res. 2016 Apr;11(4):630-5. doi: 10.4103\/1673-5374.180749. PMC4870921
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL6/J
Assessments: Coulter AcT 10 Hematology Analyzer, Enzyme-linked immunosorbent assay, Platelet aggregometry, Tail bleed times, Thromboelastometry, righting reflex response time
Citation: Martin GE, Xia B, Kim Y, Johnson MD, Veile R, Friend LA, Makley AT, Caldwell CC, Goodman MD. Platelet Function Changes in a Time-Dependent Manner Following Traumatic Brain Injury in a Murine ModelShock. 2018 Nov;50(5):551-556. doi: 10.1097\/SHK.0000000000001056.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: blood pH, Home Cage behavioral test, Immunohistochemistry (IHC), Nissl staining, Rectal temperature, TUNEL staining, Western blot, adhesive removal test, cylinder test, Evans blue dye, mean arterial blood pressure, RT–PCR
Citation: Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1417-30. doi: 10.1089\/neu.2013.3251. Epub 2014 Jul 7. PMC4132583
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Spectrometer
Citation: Shochat A, Abookasis D. Differential effects of early postinjury treatment with neuroprotective drugs in a mouse model using diffuse reflectance spectroscopyNeurophotonics. 2015 Jan;2(1):015001. doi: 10.1117\/1.NPh.2.1.015001. Epub 2015 Jan 22. PMC4478758
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6 (transgenic)
Assessments: Neurological Severity Score (NSS), Beam walk test, Blood ethanol assay, Blood gas analysis, Blood glial fibrillary acidic protein, Confocal images, Immunostaining, nitrocellulose-membrane sandwich immunoassay
Citation: Chandrasekar A, Olde Heuvel F, Wepler M, Rehman R, Palmer A, Catanese A, Linkus B, Ludolph A, Boeckers T, Huber-Lang M, Radermacher P, Roselli F. The Neuroprotective Effect of Ethanol Intoxication in Traumatic Brain Injury Is Associated with the Suppression of ErbB Signaling in Parvalbumin-Positive InterneuronsJ Neurotrauma. 2018 Nov 15;35(22):2718-2735. doi: 10.1089\/neu.2017.5270. Epub 2018 Jul 23.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Hematoxylin and Eosin, Neurological Severity Score (NSS), Nissl staining, Timm stain
Citation: Ezaki J, Shimada R, Shibuya M, Kibayashi K. Hippocampal neuronal degeneration in the traumatic brain injury mouse: non-trivial effect of scalp incisionNeurol Res. 2016 Nov;38(11):994-1002. doi: 10.1080\/01616412.2016.1228746. Epub 2016 Sep 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Prussian blue staining, Cerebral blood flow, COIS imaging, Immunohistochemistry (IHC), seizure activity
Citation: Bouley J, Chung DY, Ayata C, Brown RH Jr, Henninger N. Cortical Spreading Depression Denotes Concussion InjuryJ Neurotrauma. 2019 Apr 1;36(7):1008-1017. doi: 10.1089\/neu.2018.5844. Epub 2018 Aug 24. PMC6444888
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Brain water content, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Evans Blue Extravasation, Magnetic resonance imaging (MRI), Western Blot, Y-maze, open-field, rotarod
Citation: Shultz SR, Sun M, Wright DK, Brady RD, Liu S, Beynon S, Schmidt SF, Kaye AH, Hamilton JA, O'Brien TJ, Grills BL, McDonald SJ. Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitraumaJ Cereb Blood Flow Metab. 2015 Aug;35(8):1339-47. doi: 10.1038\/jcbfm.2015.56. Epub 2015 Apr 8. PMC4528010
