On page 1 showing 1 ~ 20 out of 46 results
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam balance test, Morris Water Maze (MWM), Beam walk test
Citation: Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL. A controlled cortical impact model of traumatic brain injury in the ratJ Neurosci Methods. 1991 Oct;39(3):253-62. doi: 10.1016\/0165-0270(91)90104-8.
TBI Model Type: Blast model
Organism Species: pig
Organism Strain: No strain reported
Assessments: stress relaxation, Fractional Zener constitutive model, fractional Zener constitutive model, unconfined compression test
Citation: McCarty AK, Zhang L, Hansen S, Jackson WJ, Bentil SA. Viscoelastic properties of shock wave exposed brain tissue subjected to unconfined compression experimentsJ Mech Behav Biomed Mater. 2019 Dec;100:103380. doi: 10.1016\/j.jmbbm.2019.103380. Epub 2019 Aug 8.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Cui CM, Gao JL, Cui Y, Sun LQ, Wang YC, Wang KJ, Li R, Tian YX, Cui JZ. Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic deathMol Med Rep. 2015 Aug;12(2):2323-8. doi: 10.3892\/mmr.2015.3611. Epub 2015 Apr 15.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: flow cytometry, ATP detection, Bradford method, Hematoxylin and eosin, Immunofluorescence, L-lactate assay kit, Morris Water Maze (MWM)
Citation: Dong T, Zhang Q, Hamblin MR, Wu MX. Low-level light in combination with metabolic modulators for effective therapy of injured brainJ Cereb Blood Flow Metab. 2015 Sep;35(9):1435-44. doi: 10.1038\/jcbfm.2015.87. Epub 2015 May 13. PMC4640344
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Electrophysiological recording, Propidium iodideluorescence
Citation: Effgen GB, Vogel EW 3rd, Lynch KA, Lobel A, Hue CD, Meaney DF, Bass CR, Morrison B 3rd. Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice culturesJ Neurotrauma. 2014 Jul 1;31(13):1202-10. doi: 10.1089\/neu.2013.3227. Epub 2014 May 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Karakaya D, Cakir-Aktas C, Uzun S, Soylemezoglu F, Mut M. Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain InjuryNeurocrit Care. 2022 Jun;36(3):802-814. doi: 10.1007\/s12028-021-01381-3. Epub 2021 Nov 16.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Albino
Assessments: Garcia Test
Citation: Ozturk Y, Bozkurt I, Guvenc Y, Kepoglu U, Cingirt M, Gulbahar O, Ozcerezci T, Senturk S, Yaman ME. Modafinil attenuates the neuroinflammatory response after experimental traumatic brain injuryJ Neurosurg Sci. 2021 Sep 21. doi: 10.23736\/S0390-5616.21.05382-0. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: strip chart, blood pH, blood pO2, blood pCO2, blood HCO3
Citation: Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanicsJ Neurosurg. 1994 Feb;80(2):291-300. doi: 10.3171\/jns.1994.80.2.0291.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: No strain reported
Assessments: immunofluorescence, Western blot
Citation: Cai Z, Zhu W, Zhao H, Yang P, Yang Y, Xu F. Dynamic Expression of Platelet-Derived Growth Factor-D and Phosphorylated Platelet-Derived Growth Factor Receptor-Β after Traumatic Brain Injury in RatsClin Lab. 2020 Nov 1;66(11). doi: 10.7754\/Clin.Lab.2020.200328.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hang test, Immunofluorescence, Nissl staining, Western blot, tail suspension test
Citation: Selvakumar GP, Ahmed ME, Iyer SS, Thangavel R, Kempuraj D, Raikwar SP, Bazley K, Wu K, Khan A, Kukulka K, Bussinger B, Zaheer S, Burton C, James D, Zaheer A. Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain InjuryExp Neurobiol. 2020 Jun 30;29(3):230-248. doi: 10.5607\/en20017. PMC7344375
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Histology, Morris Water Maze (MWM)
Citation: Shishido H, Kishimoto Y, Kawai N, Toyota Y, Ueno M, Kubota T, Kirino Y, Tamiya T. Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer's diseaseNeurosci Lett. 2016 Aug 26;629:62-67. doi: 10.1016\/j.neulet.2016.06.066. Epub 2016 Jun 29.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Lewis
Assessments: Immunohistochemistry (IHC)
Citation: Xu K, Yang Z, Shi R, Luo C, Zhang Z. Expression of aryl hydrocarbon receptor in rat brain lesions following traumatic brain injuryDiagn Pathol. 2016 Aug 9;11(1):72. doi: 10.1186\/s13000-016-0522-2. PMC4977631
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, TUNEL staining
Citation: Park CO, Yi HG. Apoptotic change and NOS activity in the experimental animal diffuse axonal injury modelYonsei Med J. 2001 Oct;42(5):518-26. doi: 10.3349\/ymj.2001.42.5.518.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, brain tissue damage, immunocytochemistry, quantify the double-positive cells
Citation: Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS.J Neuroinflammation. 2016 Apr 22;13(1):88. doi: 10.1186/s12974-016-0544-4.10.1186/s12974-016-0544-4
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Lewis
Assessments: Immunohistochemistry (IHC), MTT assay, qPCR
Citation: Zhang Z, Zhang ZY, Wu Y, Schluesener HJ.Brain Res. 2012 Jun 21;1461:102-10. doi: 10.1016/j.brainres.2012.04.038. Epub 2012 Apr 27.
TBI Model Type: Weight-drop model
Organism Species: mouse
Citation: Payette DJ, Xie J, Shirwany N, Guo Q.Exacerbation of apoptosis of cortical neurons following traumatic brain injury in par-4 transgenic miceInt J Clin Exp Pathol. 2008 Jan 1;1(1):44-56.PMC2480534
TBI Model Type: Weight-drop model
Citation: Feng D, Xu W, Chen G, Hang C, Gao H, Yin H.Influence of glutamine on intestinal inflammatory response, mucosa structure alterations and apoptosis following traumatic brain injury in ratsJ Int Med Res. 2007 Sep-Oct;35(5):644-56. doi: 10.1177/147323000703500509.10.1177/147323000703500509
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar-Albino
Assessments: Quantitative Real-Time PCR Analysis
Citation: Ozisik K, Ozisik P, Yildirim E, Misirlioglu M, Tuncer S.Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injuryTransplant Proc. 2006 Nov;38(9):2784-7. doi: 10.1016/j.transproceed.2006.08.100.10.1016/j.transproceed.2006.08.100
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: TTC staining method, Current responses, Enzyme-linked immunosorbent assay, Nissl staining, brain water content, immunofluorescent staining, neurological severity score, wet and dry weight method
Citation: Zhai PP, Xu LH, Yang JJ, Jiang ZL, Zhao GW, Sun L, Wang GH, Li X.Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury.Neuropharmacology. 2015 Aug;95:1-11. doi: 10.1016/j.neuropharm.2015.02.026. Epub 2015 Mar 5.
