On page 1 showing 1 ~ 20 out of 420 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain water content, Immunofluorescence, Immunohistochemistry (IHC), Mitochondrial MDA, SOD Content, Prussian Blue Staining, Reactive Oxygen Species Content, TUNEL staining, Western blot, dihydroethidium staining
Citation: Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain InjuryOxid Med Cell Longev. 2018 Aug 27;2018:4783602. doi: 10.1155\/2018\/4783602. eCollection 2018. PMC6129854
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: OF1
Assessments: Immunohistochemistry (IHC), Ventricular volume, antibody-coupled magnetic bead system, qRT-PCR
Citation: Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Oré MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B. Role of microglia in a mouse model of paediatric traumatic brain injuryBrain Behav Immun. 2017 Jul;63:197-209. doi: 10.1016\/j.bbi.2016.11.001. Epub 2016 Nov 4. PMC5441571
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J (transgenic)
Assessments: Enzyme-linked immunosorbent assay (ELISA), qRT-PCR
Citation: Febinger HY, Thomasy HE, Pavlova MN, Ringgold KM, Barf PR, George AM, Grillo JN, Bachstetter AD, Garcia JA, Cardona AE, Opp MR, Gemma C. Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injuryJ Neuroinflammation. 2015 Sep 2;12:154. doi: 10.1186\/s12974-015-0386-5. PMC4557842
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Novel object location test, Novel object recognition test, qPCR, Compound action potential (CAP) recording, Immunohistochemistry (IHC)
Citation: Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP. Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of MicrogliaJ Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523\/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19. PMC9121837
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Elevated plus maze test, Histology, Novel object recognition test, Open field test, T-Maze, Western blot, infarct volume
Citation: Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A(3) receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injuryJ Neuroinflammation. 2020 Nov 12;17(1):339. doi: 10.1186\/s12974-020-02009-7. PMC7659122
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Array image analysis, Beam walk test, Cytokine array, Immunohistochemistry (IHC), Neurological Severity Score (NSS), confocal imaging, phospho-Akt array
Citation: Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F. Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injuryInt Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016\/j.intimp.2017.08.002. Epub 2017 Aug 12.
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Western blot, optical density, qRT-PCR
Citation: Tian Y, Zhao R, Li X, Zhou J, Zhan D, Wang Y, He Y, Zhang J, Yuan H. Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in miceExp Anim. 2022 Mar 7. doi: 10.1538\/expanim.21-0148. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: PCR, Western blot
Citation: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in miceBrain Res. 2014 Oct 17;1585:13-22. doi: 10.1016\/j.brainres.2014.08.026. Epub 2014 Aug 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam walk test, open field test, Five serial choice reaction time task, time-to-right
Citation: Mychasiuk R, Hehar H, Esser MJ. A mild traumatic brain injury (mTBI) induces secondary attention-deficit hyperactivity disorder-like symptomology in young ratsBehav Brain Res. 2015 Jun 1;286:285-92. doi: 10.1016\/j.bbr.2015.03.010. Epub 2015 Mar 11.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Neurological Severity Score (NSS), RT-PCR
Citation: Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNeurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016\\/j.neulet.2014.10.037. Epub 2014 Oct 28.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Zinc staining
Citation: Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW. Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrusJ Trace Elem Med Biol. 2014 Oct;28(4):474-81. doi: 10.1016\/j.jtemb.2014.07.007. Epub 2014 Aug 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Hematoxylin and Eosin, Immunohistochemistry (IHC)
Citation: Feng Y, Gao Y, Wang T, Tao L, Qiu S, Zhao X. A longitudinal study of the mechanical properties of injured brain tissue in a mouse modelJ Mech Behav Biomed Mater. 2017 Jul;71:407-415. doi: 10.1016\/j.jmbbm.2017.04.008. Epub 2017 Apr 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Glasgow Coma Scale, TUNEL staining, Immunohistochemistry (IHC)
Citation: Zhaba WD, Deji QZ, Gao SQ, Han YL, Gao CC, Deng HJ, Liu XL, Li T, Zhou ML. Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injuryNeuroreport. 2021 Apr 7;32(6):472-478. doi: 10.1097\/WNR.0000000000001619.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), Modified limb-placing, Western Blot, modified Voetsch neuroscore
Citation: Chang CZ, Wu SC, Kwan AL, Lin CL. Magnesium Lithospermate B Implicates 3'-5'-Cyclic Adenosine Monophosphate\/Protein Kinase A Pathway and N-Methyl-d-Aspartate Receptors in an Experimental Traumatic Brain InjuryWorld Neurosurg. 2015 Oct;84(4):954-63. doi: 10.1016\/j.wneu.2015.05.075. Epub 2015 Jun 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Passive avoidance test, Neurological Severity Score (NSS), passive avoidance test
Citation: Khalin I, Jamari NL, Razak NB, Hasain ZB, Nor MA, Zainudin MH, Omar AB, Alyautdin R. A mouse model of weight-drop closed head injury: emphasis on cognitive and neurological deficiencyNeural Regen Res. 2016 Apr;11(4):630-5. doi: 10.4103\/1673-5374.180749. PMC4870921
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: qRT-PCR
Citation: Tang YL, Fang LJ, Zhong LY, Jiang J, Dong XY, Feng Z. Hub genes and key pathways of traumatic brain injury: bioinformatics analysis and in vivo validationNeural Regen Res. 2020 Dec;15(12):2262-2269. doi: 10.4103\/1673-5374.284996. PMC7749465
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Albino
Assessments: Histology, Lowry method, Tissue Caspase-3, Tissue Glutathione Peroxidase, Tissue Malondialdehyde, Tissue Superoxide Dismutase
Citation: Özay R, Türkoğlu E, Gürer B, Dolgun H, Evirgen O, Ergüder Bİ, Hayırlı N, Gürses L, Şekerci Z, Yılmaz ER. Does Decorin Protect Neuronal Tissue via Its Antioxidant and Antiinflammatory Activity from Traumatic Brain Injury? An Experimental StudyWorld Neurosurg. 2017 Jan;97:407-415. doi: 10.1016\/j.wneu.2016.09.115. Epub 2016 Oct 12.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Albino
Assessments: Histology, Lowry method, Tissue Caspase-3 Analysis, Tissue Glutathione Peroxidase Analysis, Tissue Malondialdehyde Analysis, Tissue Nitric Oxide Analysis, Tissue Superoxide Dismutase Analysis
Citation: Özay R, Türkoğlu ME, Gürer B, Dolgun H, Evirgen O, Ergüder Bİ, Hayırlı N, Gürses L, Şekerci Z. The Protective Effect of Omeprazole Against Traumatic Brain Injury: An Experimental StudyWorld Neurosurg. 2017 Aug;104:634-643. doi: 10.1016\/j.wneu.2017.04.136. Epub 2017 Apr 28.
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Diffusion tensor imaging(DTI), Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), T2-weighted imaging
Citation: Hutchinson EB, Schwerin SC, Radomski KL, Irfanoglu MO, Juliano SL, Pierpaoli CM. Quantitative MRI and DTI Abnormalities During the Acute Period Following CCI in the FerretShock. 2016 Sep;46(3 Suppl 1):167-76. doi: 10.1097\/SHK.0000000000000659. PMC4978600
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), level of homocysteine, qRT-PCR
Citation: Tommy T, Islam AA, Hatta M, Bukhari A, Nasrullah, Adhimarta W, Aminuddin, Zainuddin AA. Effect of folinic acid on serum homocysteine, TNFα, IL-10, and HMGB1 gene expression in head injury modelAnn Med Surg (Lond). 2021 Apr 6;65:102273. doi: 10.1016\/j.amsu.2021.102273. eCollection 2021 May. PMC8100092
