On page 1 showing 1 ~ 20 out of 65 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: OF1
Assessments: Immunohistochemistry (IHC), Ventricular volume, antibody-coupled magnetic bead system, qRT-PCR
Citation: Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Oré MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B. Role of microglia in a mouse model of paediatric traumatic brain injuryBrain Behav Immun. 2017 Jul;63:197-209. doi: 10.1016\/j.bbi.2016.11.001. Epub 2016 Nov 4. PMC5441571
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam walk test, open field test, Five serial choice reaction time task, time-to-right
Citation: Mychasiuk R, Hehar H, Esser MJ. A mild traumatic brain injury (mTBI) induces secondary attention-deficit hyperactivity disorder-like symptomology in young ratsBehav Brain Res. 2015 Jun 1;286:285-92. doi: 10.1016\/j.bbr.2015.03.010. Epub 2015 Mar 11.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay, Immunohistochemistry (IHC), Neurological function, RT-PCR, Western blot, Differential gene expression analysis
Citation: Xiong LL, Hu Y, Zhang P, Zhang Z, Li LH, Gao GD, Zhou XF, Wang TH. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated NeuroplasticityMol Neurobiol. 2018 Mar;55(3):2696-2711. doi: 10.1007\/s12035-017-0551-1. Epub 2017 Apr 18.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Image analysis, Morris Water Maze (MWM)
Citation: Barot J, Saxena B. Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological studyJ Tradit Complement Med. 2021 Jan 8;11(4):318-327. doi: 10.1016\/j.jtcme.2021.01.003. eCollection 2021 Jul. PMC8240337
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Immunohistochemistry (IHC), Magnetic resonance imaging (MRI)
Citation: Tu TW, Lescher JD, Williams RA, Jikaria N, Turtzo LC, Frank JA. Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 1;34(1):248-256. doi: 10.1089\/neu.2015.4355. Epub 2016 Apr 11. PMC5198143
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Histology
Citation: Sindelar B, Bailes J, Sherman S, Finan J, Stone J, Lee J, Ahmadian S, Zhou Y, Patel V, Smith D. Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a Porcine Controlled Cortical Impact ModelJ Neurotrauma. 2017 Apr 15;34(8):1703-1709. doi: 10.1089\/neu.2016.4648. Epub 2016 Dec 16.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Body temperature, Blood gas analysis, blood pH, laser doppler flowmetry
Citation: Roof RL, Hall ED. Estrogen-related gender difference in survival rate and cortical blood flow after impact-acceleration head injury in ratsJ Neurotrauma. 2000 Dec;17(12):1155-69. doi: 10.1089\/neu.2000.17.1155.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6-SJLF1
Assessments: Conditioned fear testing, Morris Water Maze (MWM), Rotorod test, Histology, shock sensitivity testing
Citation: Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injuryJ Neurotrauma. 2007 Apr;24(4):657-73. doi: 10.1089\/neu.2006.0011. PMC2435168
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Fluid percussion injury model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Cardiac output, Cerebral blood flow, renal blood flow, Doppler imaging, Pulsed wave Doppler measurements, Transesophageal echocardiography, blood gas, central venous pressure, intracranial pressure monitor
Citation: Adedipe A, John AS, Krishnamoorthy V, Wang X, Steck DT, Ferreira R, White N, Stern S. Left Ventricular Function in the Initial Period After Severe Traumatic Brain Injury in SwineNeurocrit Care. 2022 Mar 21. doi: 10.1007\/s12028-022-01468-5. Online ahead of print.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Learning, Glutamate Excitotoxicity, Immunoblot, Memory, qRT-PCR, ataxia, bending, circling, corkscrew swimming, clonic-seizure metrics, modified Puppala, Fluid Content Measurement
Citation: Hentig J, Campbell LJ, Cloghessy K, Lee M, Boggess W, Hyde DR. Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2aBiomedicines. 2021 Dec 24;10(1):32. doi: 10.3390\/biomedicines10010032. PMC8773121
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterationsClin Exp Pharmacol Physiol. 2016 Nov;43(11):1107-1114. doi: 10.1111\/1440-1681.12650.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Other
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Histology, Hematoxylin and Eosin
Citation: Duhaime AC, Margulies SS, Durham SR, O'Rourke MM, Golden JA, Marwaha S, Raghupathi R. Maturation-dependent response of the piglet brain to scaled cortical impactJ Neurosurg. 2000 Sep;93(3):455-62. doi: 10.3171\/jns.2000.93.3.0455.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: hindlimb reflexive ability, single probe trial, Cortical lesion volume, Morris Mater Maze (MWM), Beam balance test, Beam walk test, righting reflex, Rotarod test, Cresyl violet staining
Citation: Monaco CM, Mattiola VV, Folweiler KA, Tay JK, Yelleswarapu NK, Curatolo LM, Matter AM, Cheng JP, Kline AE. Environmental enrichment promotes robust functional and histological benefits in female rats after controlled cortical impact injuryExp Neurol. 2013 Sep;247:410-8. doi: 10.1016\/j.expneurol.2013.01.007. Epub 2013 Jan 16. PMC3644389
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Agilent 2200 TapeStation assay, DEX, Immunohistochemistry (IHC), LTP assessment, NanoString nCounter analysis, open field test, Paired-pulse ratio, Trace fear conditioning, Y-maze task, electrophysiological assessment
Citation: Tapp ZM, Cornelius S, Oberster A, Kumar JE, Atluri R, Witcher KG, Oliver B, Bray C, Velasquez J, Zhao F, Peng J, Sheridan J, Askwith C, Godbout JP, Kokiko-Cochran ON. Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injuryExp Neurol. 2022 Jul;353:114058. doi: 10.1016\/j.expneurol.2022.114058. Epub 2022 Mar 28. PMC9068267
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Differential gene expression analysis, qRT-PCR, T-maze
Citation: Maheras AL, Dix B, Carmo OMS, Young AE, Gill VN, Sun JL, Booker AR, Thomason HA, Ibrahim AE, Stanislaw L, Dallego JC, Ngo CN, Chen A, Fortini BK, Spence RD. Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult ZebrafisheNeuro. 2018 Jan 3;5(1):ENEURO.0208-17.2017. doi: 10.1523\/ENEURO.0208-17.2017. eCollection 2018 Jan-Feb. PMC5752677
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: in-house bred
Assessments: Beam walk test, Elevated plus maze, Forced swim test, Novel context mismatch test, open field test, qRT-PCR
Citation: Mychasiuk R, Hehar H, Candy S, Ma I, Esser MJ. The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomesJ Neurosci Methods. 2016 Jan 15;257:168-78. doi: 10.1016\/j.jneumeth.2015.10.002. Epub 2015 Oct 17.
