On page 1 showing 1 ~ 20 out of 45 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain water content, Immunofluorescence, Immunohistochemistry (IHC), Mitochondrial MDA, SOD Content, Prussian Blue Staining, Reactive Oxygen Species Content, TUNEL staining, Western blot, dihydroethidium staining
Citation: Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain InjuryOxid Med Cell Longev. 2018 Aug 27;2018:4783602. doi: 10.1155\/2018\/4783602. eCollection 2018. PMC6129854
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Glasgow Coma Scale, TUNEL staining, Immunohistochemistry (IHC)
Citation: Zhaba WD, Deji QZ, Gao SQ, Han YL, Gao CC, Deng HJ, Liu XL, Li T, Zhou ML. Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injuryNeuroreport. 2021 Apr 7;32(6):472-478. doi: 10.1097\/WNR.0000000000001619.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: blood pH, Home Cage behavioral test, Immunohistochemistry (IHC), Nissl staining, Rectal temperature, TUNEL staining, Western blot, adhesive removal test, cylinder test, Evans blue dye, mean arterial blood pressure, RT–PCR
Citation: Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1417-30. doi: 10.1089\/neu.2013.3251. Epub 2014 Jul 7. PMC4132583
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), Elevated plus maze, Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Xie LL, Li SS, Fan YJ, Qi MM, Li ZZ. Melatonin alleviates traumatic brain injury-induced anxiety-like behaviors in rats: Roles of the protein kinase A\/cAMP-response element binding signaling pathwayExp Ther Med. 2022 Apr;23(4):248. doi: 10.3892\/etm.2022.11173. Epub 2022 Jan 31. PMC8855513
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Biochemical Assay, Brain water content, Hematoxylin and Eosin, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), qRT-PCR, TUNEL staining, Western blot
Citation: Tang Y, Dong X, Chen G, Ye W, Kang J, Tang Y, Feng Z. Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB\/NLRP3 Signaling PathwayNeurorehabil Neural Repair. 2020 Sep;34(9):831-843. doi: 10.1177\/1545968320948065. Epub 2020 Aug 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence staining, TUNEL staining, Western blot, Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J. Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axisNeurogastroenterol Motil. 2018 May;30(5):e13260. doi: 10.1111\/nmo.13260. Epub 2017 Nov 27.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: CM-DiI dye, DiR dye, Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), TUNEL staining, Western blot, qRT-PCR
Citation: Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC. MSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in ratAging (Albany NY). 2020 Sep 23;12(18):18274-18296. doi: 10.18632\/aging.103692. Online ahead of print. PMC7585083
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Brain water content, Hematoxylin and Eosin, qRT-PCR, Western blot, Neurological Severity Score (NSS), TUNEL staining
Citation: Li Z, Wang Y, Zeng G, Zheng X, Wang W, Ling Y, Tang H, Zhang J. Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in ratsAm J Transl Res. 2017 Dec 15;9(12):5653-5661. eCollection 2017. PMC5752915
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ATP Assay, Behavioral Testing, Activity score, Brain water content, Fluoro-jade C staining (FJC), Immunofluorescence, Neurological score, RT-PCR, TUNEL staining, Western blot
Citation: Chen C, Lu L, Zhu J, Gu X, Liu B, Li D, Chen G. Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injuryBrain Res. 2021 Dec 15;1773:147685. doi: 10.1016\/j.brainres.2021.147685. Epub 2021 Oct 9.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: TUNEL staining, Brain water content, Fluoro-Jade B staining (FJB), Immunofluorescence, RT- PCR, Western blot, modified Garcia score
Citation: Rui Q, Ni H, Gao F, Dang B, Li D, Gao R, Chen G. LRRK2 Contributes to Secondary Brain Injury Through a p38\/Drosha Signaling Pathway After Traumatic Brain Injury in RatsFront Cell Neurosci. 2018 Mar 1;12:51. doi: 10.3389\/fncel.2018.00051. eCollection 2018. PMC5837969
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, spectrophotometer
Citation: Dai W, Wang H, Fang J, Zhu Y, Zhou J, Wang X, Zhou Y, Zhou M. Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathwayBrain Res Bull. 2018 Jun;140:65-71. doi: 10.1016\/j.brainresbull.2018.03.020. Epub 2018 Apr 4.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, TUNEL staining
Citation: Park CO, Yi HG. Apoptotic change and NOS activity in the experimental animal diffuse axonal injury modelYonsei Med J. 2001 Oct;42(5):518-26. doi: 10.3349\/ymj.2001.42.5.518.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beta-hydroxybutyrate level, Brainwater content, Cytochrome c assay, TUNEL staining, glucose measurement
Citation: Hu ZG, Wang HD, Jin W, Yin HX. Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile ratsAnn Clin Lab Sci. 2009 Winter;39(1):76-83.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Balb/C
Assessments: Immunohistochemistry (IHC), Xenogen imaging, Hematoxylin and eosin, TUNEL staining
Citation: Lopez NE, Gaston L, Lopez KR, Coimbra RC, Hageny A, Putnam J, Eliceiri B, Coimbra R, Bansal V.Brain Res. 2012 Dec 13;1489:140-8. doi: 10.1016/j.brainres.2012.10.031. Epub 2012 Oct 23.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Nissl staning, Beam walk test, Bradford method, Immunohistochemistry (IHC), TUNEL staining, EMSA, ELISA, Immunofluorescence
Citation: Zhang D, Hu Y, Sun Q, Zhao J, Cong Z, Liu H, Zhou M, Li K, Hang C.Neuroscience. 2013 May 15;238:209-17. doi: 10.1016/j.neuroscience.2013.02.022. Epub 2013 Feb 24.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, TUNEL staining, immunoenzyme-linked immunocytochemistry, immunofluorescence staining, modified Neurological Severity Score (mNSS)
Citation: Liu SJ, Zou Y, Belegu V, Lv LY, Lin N, Wang TY, McDonald JW, Zhou X, Xia QJ, Wang TH.Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism.J Neuroinflammation. 2014 Apr 2;11:66. doi: 10.1186/1742-2094-11-66.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Caspase Enzyme Activity, Feeding Latency, Histopathology, rt-PCR, TUNEL staining, Western blot
Citation: Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, Gaboury I, Merali Z, Mackenzie AE, Hutchison JS.J Neurotrauma. 2007 Feb;24(2):338-53. doi: 10.1089/neu.2006.003615.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Balb/C
Assessments: Cerebral Tissue Damage, Histology, Neurologic Severity Score (NSS), TUNEL staining, Hematoxylin and eosin
Citation: Reshef A, Shirvan A, Shohami E, Grimberg H, Levin G, Cohen A, Trembovler V, Ziv I.J Neurotrauma. 2008 Jun;25(6):569-80. doi: 10.1089/neu.2007.0341.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: ELISA, TUNEL staining, Grip test, rt-PCR
Citation: Jin W, Wang H, Yan W, Zhu L, Hu Z, Ding Y, Tang K.J Neurotrauma. 2009 Jan;26(1):131-9. doi: 10.1089/neu.2008.0655.
