On page 1 showing 1 ~ 20 out of 36 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Neurological Severity Score (NSS), RT-PCR
Citation: Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNeurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016\\/j.neulet.2014.10.037. Epub 2014 Oct 28.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay, Immunohistochemistry (IHC), Neurological function, RT-PCR, Western blot, Differential gene expression analysis
Citation: Xiong LL, Hu Y, Zhang P, Zhang Z, Li LH, Gao GD, Zhou XF, Wang TH. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated NeuroplasticityMol Neurobiol. 2018 Mar;55(3):2696-2711. doi: 10.1007\/s12035-017-0551-1. Epub 2017 Apr 18.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: blood pH, Home Cage behavioral test, Immunohistochemistry (IHC), Nissl staining, Rectal temperature, TUNEL staining, Western blot, adhesive removal test, cylinder test, Evans blue dye, mean arterial blood pressure, RT–PCR
Citation: Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1417-30. doi: 10.1089\/neu.2013.3251. Epub 2014 Jul 7. PMC4132583
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wister
Assessments: Enzyme-linked immunosorbent assay (ELISA), Hematoxylin and Eosin, RT-PCR, Western blot, permeability assay
Citation: Lang Y, Fu F, Sun D, Xi C, Chen F. Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain InjuryPLoS One. 2015 Jul 17;10(7):e0133215. doi: 10.1371\/journal.pone.0133215. eCollection 2015. PMC4505891
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: RT-PCR
Citation: Sandhir R, Berman NE. Age-dependent response of CCAAT\/enhancer binding proteins following traumatic brain injury in miceNeurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016\/j.neuint.2009.10.002. Epub 2009 Oct 13. PMC2815015
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Morris Water Maze (MWM), Neurologic Deficit Scoring, Western Blot, Novel object recognition test, RT-PCR
Citation: Cheng T, Yang B, Li D, Ma S, Tian Y, Qu R, Zhang W, Zhang Y, Hu K, Guan F, Wang J. Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain InjuryCell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007\/s10571-015-0159-9. Epub 2015 Feb 1. PMC4481175
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), RT-PCR, Immunohistochemistry (IHC), Western blot, Brain water content, cortical oxidative stress
Citation: Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ATP Assay, Behavioral Testing, Activity score, Brain water content, Fluoro-jade C staining (FJC), Immunofluorescence, Neurological score, RT-PCR, TUNEL staining, Western blot
Citation: Chen C, Lu L, Zhu J, Gu X, Liu B, Li D, Chen G. Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injuryBrain Res. 2021 Dec 15;1773:147685. doi: 10.1016\/j.brainres.2021.147685. Epub 2021 Oct 9.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Han
Assessments: RT-PCR, elevated plus maze, Barnes Maze test, Microarray, Rotarod test, Enzyme-linked immunosorbent assay (ELISA), rotating pole
Citation: Chakraborty N, Hammamieh R, Gautam A, Miller SA, Condlin ML, Jett M, Scrimgeour AG. TBI weight-drop model with variable impact heights differentially perturbs hippocampus-cerebellum specific transcriptomic profileExp Neurol. 2021 Jan;335:113516. doi: 10.1016\/j.expneurol.2020.113516. Epub 2020 Oct 22.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), LC-MS/MS analysis, RT-PCR, Western blot
Citation: Wang H, Chen J, Gao C, Chen W, Chen G, Zhang M, Luo C, Wang T, Chen X, Tao L. TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in ratsLife Sci. 2021 Jan 1;264:118631. doi: 10.1016\/j.lfs.2020.118631. Epub 2020 Oct 22.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Electroretinogram, Light aversion, NanoString analysis, qPCR, optic nerve axon counts, RT-PCR
Citation: Honig MG, Del Mar NA, Henderson DL, O'Neal D, Doty JB, Cox R, Li C, Perry AM, Moore BM, Reiner A. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain InjuryFront Neurosci. 2021 Oct 29;15:701317. doi: 10.3389\/fnins.2021.701317. eCollection 2021. PMC8585747
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, TUNEL staining
Citation: Park CO, Yi HG. Apoptotic change and NOS activity in the experimental animal diffuse axonal injury modelYonsei Med J. 2001 Oct;42(5):518-26. doi: 10.3349\/ymj.2001.42.5.518.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Bioanalyzer DIANA mirPath, Histology, RT-PCR, qRT-PCR, Hematoxylin and Eosin
Citation: Chandran R, Sharma A, Bhomia M, Balakathiresan NS, Knollmann-Ritschel BE, Maheshwari RK. Differential expression of microRNAs in the brains of mice subjected to increasing grade of mild traumatic brain injuryBrain Inj. 2017;31(1):106-119. doi: 10.1080\/02699052.2016.1213420. Epub 2016 Nov 7.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Ma Y, Liu T, Fu J, Fu S, Hu C, Sun B, Fan X, Zhu J. Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain InjuryJ Nutr. 2019 Sep 1;149(9):1543-1552. doi: 10.1093\/jn\/nxz105.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ELISA, Brain water content, EMSA, rt-PCR, Immunohistochemistry (IHC), Western blot
Citation: Lv Q, Fan X, Xu G, Liu Q, Tian L, Cai X, Sun W, Wang X, Cai Q, Bao Y, Zhou L, Zhang Y, Ge L, Guo R, Liu X.Brain Res. 2013 Feb 1;1493:80-9. doi: 10.1016/j.brainres.2012.11.028. Epub 2012 Nov 23.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, TUNEL staining, immunoenzyme-linked immunocytochemistry, immunofluorescence staining, modified Neurological Severity Score (mNSS)
Citation: Liu SJ, Zou Y, Belegu V, Lv LY, Lin N, Wang TY, McDonald JW, Zhou X, Xia QJ, Wang TH.Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism.J Neuroinflammation. 2014 Apr 2;11:66. doi: 10.1186/1742-2094-11-66.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: ELISA, H & E staining, Luxol fast blue staining, Nogo-A mRNA assay, RT-PCR, Water content, Western blot analysis
Citation: Chao PK, Lu KT, Jhu JY, Wo YY, Huang TC, Ro LS, Yang YL.Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expressionJ Neuroinflammation. 2012 Jun 7;9:121. doi: 10.1186/1742-2094-9-121.PMC341669510.1186/1742-2094-9-121
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Neurological Severity Score (NSS), RT-PCR, terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling
Citation: Wang YC, Xia QJ, Ba YC, Wang TY, LiN N, Zou Y, Shang FF, Zhou XF, Wang TH, Fu XM, Qi JG.Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.Cytotherapy. 2014 Jul;16(7):1000-10. doi: 10.1016/j.jcyt.2013.12.009. Epub 2014 Feb 28.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Western blot, Chemiluminescence assay, Hematoxylin and eosin, rt-PCR
Citation: Lu KT, Wang YW, Wo YY, Yang YL.Neurosci Lett. 2005 Sep 23;386(1):40-5. doi: 10.1016/j.neulet.2005.05.057.
