On page 1 showing 1 ~ 20 out of 45 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: OF1
Assessments: Immunohistochemistry (IHC), Ventricular volume, antibody-coupled magnetic bead system, qRT-PCR
Citation: Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Oré MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B. Role of microglia in a mouse model of paediatric traumatic brain injuryBrain Behav Immun. 2017 Jul;63:197-209. doi: 10.1016\/j.bbi.2016.11.001. Epub 2016 Nov 4. PMC5441571
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J (transgenic)
Assessments: Enzyme-linked immunosorbent assay (ELISA), qRT-PCR
Citation: Febinger HY, Thomasy HE, Pavlova MN, Ringgold KM, Barf PR, George AM, Grillo JN, Bachstetter AD, Garcia JA, Cardona AE, Opp MR, Gemma C. Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injuryJ Neuroinflammation. 2015 Sep 2;12:154. doi: 10.1186\/s12974-015-0386-5. PMC4557842
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Western blot, optical density, qRT-PCR
Citation: Tian Y, Zhao R, Li X, Zhou J, Zhan D, Wang Y, He Y, Zhang J, Yuan H. Alterations of microRNAs expression profiles in small extracellular vesicle after traumatic brain injury in miceExp Anim. 2022 Mar 7. doi: 10.1538\/expanim.21-0148. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: qRT-PCR
Citation: Tang YL, Fang LJ, Zhong LY, Jiang J, Dong XY, Feng Z. Hub genes and key pathways of traumatic brain injury: bioinformatics analysis and in vivo validationNeural Regen Res. 2020 Dec;15(12):2262-2269. doi: 10.4103\/1673-5374.284996. PMC7749465
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), level of homocysteine, qRT-PCR
Citation: Tommy T, Islam AA, Hatta M, Bukhari A, Nasrullah, Adhimarta W, Aminuddin, Zainuddin AA. Effect of folinic acid on serum homocysteine, TNFα, IL-10, and HMGB1 gene expression in head injury modelAnn Med Surg (Lond). 2021 Apr 6;65:102273. doi: 10.1016\/j.amsu.2021.102273. eCollection 2021 May. PMC8100092
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar–Kyoto
Assessments: BK channel current, CM-H2DCFDA staining, qRT-PCR, pressure myography
Citation: Szarka N, Pabbidi MR, Amrein K, Czeiter E, Berta G, Pohoczky K, Helyes Z, Ungvari Z, Koller A, Buki A, Toth P. Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H(2)O(2) and TRPV4-Dependent Activation of BK(ca) ChannelsJ Neurotrauma. 2018 Apr 1;35(7):930-939. doi: 10.1089\/neu.2017.5056. Epub 2018 Jan 12. PMC5865628
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Biochemical Assay, Brain water content, Hematoxylin and Eosin, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), qRT-PCR, TUNEL staining, Western blot
Citation: Tang Y, Dong X, Chen G, Ye W, Kang J, Tang Y, Feng Z. Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB\/NLRP3 Signaling PathwayNeurorehabil Neural Repair. 2020 Sep;34(9):831-843. doi: 10.1177\/1545968320948065. Epub 2020 Aug 10.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Object Recognition Memory Test, Open-Field Test, Western blot, Brain Water Content, qRT-PCR
Citation: Furtado ABV, Gonçalves DF, Hartmann DD, Courtes AA, Cassol G, Nunez-Figueredo Y, Argolo DS, do Nascimento RP, Costa SL, da Silva VDA, Royes LFF, Soares FAA. JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin ExpressionMol Neurobiol. 2021 Sep;58(9):4615-4627. doi: 10.1007\/s12035-021-02436-4. Epub 2021 Jun 19.
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Learning, Glutamate Excitotoxicity, Immunoblot, Memory, qRT-PCR, ataxia, bending, circling, corkscrew swimming, clonic-seizure metrics, modified Puppala, Fluid Content Measurement
Citation: Hentig J, Campbell LJ, Cloghessy K, Lee M, Boggess W, Hyde DR. Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2aBiomedicines. 2021 Dec 24;10(1):32. doi: 10.3390\/biomedicines10010032. PMC8773121
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Evans blue dye, Immunohistochemistry (IHC), SOD activity, GSH-PX activity, MDA activity, qRT-PCR, Western blot, Brain water content
Citation: Zhang B, Wang B, Cao S, Wang Y. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative StressKorean J Physiol Pharmacol. 2015 Nov;19(6):491-7. doi: 10.4196\/kjpp.2015.19.6.491. Epub 2015 Oct 16. PMC4637351
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: CM-DiI dye, DiR dye, Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), TUNEL staining, Western blot, qRT-PCR
Citation: Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC. MSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in ratAging (Albany NY). 2020 Sep 23;12(18):18274-18296. doi: 10.18632\/aging.103692. Online ahead of print. PMC7585083
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Brain water content, Hematoxylin and Eosin, qRT-PCR, Western blot, Neurological Severity Score (NSS), TUNEL staining
Citation: Li Z, Wang Y, Zeng G, Zheng X, Wang W, Ling Y, Tang H, Zhang J. Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in ratsAm J Transl Res. 2017 Dec 15;9(12):5653-5661. eCollection 2017. PMC5752915
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Differential gene expression analysis, qRT-PCR, T-maze
Citation: Maheras AL, Dix B, Carmo OMS, Young AE, Gill VN, Sun JL, Booker AR, Thomason HA, Ibrahim AE, Stanislaw L, Dallego JC, Ngo CN, Chen A, Fortini BK, Spence RD. Genetic Pathways of Neuroregeneration in a Novel Mild Traumatic Brain Injury Model in Adult ZebrafisheNeuro. 2018 Jan 3;5(1):ENEURO.0208-17.2017. doi: 10.1523\/ENEURO.0208-17.2017. eCollection 2018 Jan-Feb. PMC5752677
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: in-house bred
Assessments: Beam walk test, Elevated plus maze, Forced swim test, Novel context mismatch test, open field test, qRT-PCR
Citation: Mychasiuk R, Hehar H, Candy S, Ma I, Esser MJ. The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomesJ Neurosci Methods. 2016 Jan 15;257:168-78. doi: 10.1016\/j.jneumeth.2015.10.002. Epub 2015 Oct 17.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Beam walk test, Elevated plus maze, Forced swim test, Novel context mismatch test, open field test, qRT-PCR
Citation: Kahriman A, Bouley J, Bosco DA, Shazeeb MS, Henninger N. Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injuryNeurosci Lett. 2022 Feb 6;771:136430. doi: 10.1016\/j.neulet.2021.136430. Epub 2021 Dec 29. PMC8821174
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL6/J
Assessments: Immunofluorescence Staining, qRT-PCR
Citation: Morganti JM, Riparip LK, Rosi S.PLoS One. 2016 Jan 25;11(1):e0148001. doi: 10.1371/journal.pone.0148001. eCollection 2016.10.1371/journal.pone.0148001
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL6/J
Assessments: Hierarchical clustering analysis, Ingenuity Pathway Analysis, qRT-PCR
Citation: Morganti JM, Riparip LK, Chou A, Liu S, Gupta N, Rosi S.J Neuroinflammation. 2016 Apr 18;13(1):80. doi: 10.1186/s12974-016-0547-1.10.1186/s12974-016-0547-1
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Bioanalyzer DIANA mirPath, Histology, RT-PCR, qRT-PCR, Hematoxylin and Eosin
Citation: Chandran R, Sharma A, Bhomia M, Balakathiresan NS, Knollmann-Ritschel BE, Maheshwari RK. Differential expression of microRNAs in the brains of mice subjected to increasing grade of mild traumatic brain injuryBrain Inj. 2017;31(1):106-119. doi: 10.1080\/02699052.2016.1213420. Epub 2016 Nov 7.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Malondialdehyde content, Neurological severity test, qRT-PCR, Superoxide Dismutase, TUNNEL, Western blot analysis, glutathione peroxidase activity
Citation: Xia D, Zhai X, Wang H, Chen Z, Fu C, Zhu M. Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injuryJ Cell Mol Med. 2019 Jun;23(6):4088-4096. doi: 10.1111\/jcmm.14296. Epub 2019 Apr 15. PMC6533507
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Morris water maze (MWM), qRT-PCR, Immunofluorescence staining, terminal deoxynucleotidyl transferase-mediated dUTP nick 3-end labeling
Citation: Liu S, Zhang L, Wu Q, Wu Q, Wang T.Chemokine CCL2 induces apoptosis in cortex following traumatic brain injury.J Mol Neurosci. 2013 Nov;51(3):1021-9. doi: 10.1007/s12031-013-0091-8. Epub 2013 Aug 11.
