On page 1 showing 1 ~ 20 out of 31 results
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Novel object location test, Novel object recognition test, qPCR, Compound action potential (CAP) recording, Immunohistochemistry (IHC)
Citation: Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP. Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of MicrogliaJ Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523\/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19. PMC9121837
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Elevated plus maze test, Histology, Novel object recognition test, Open field test, T-Maze, Western blot, infarct volume
Citation: Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A(3) receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injuryJ Neuroinflammation. 2020 Nov 12;17(1):339. doi: 10.1186\/s12974-020-02009-7. PMC7659122
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: EEG/EMG recording, Neurological Severity Score (NSS), Novel object recognition test, open field test, Hematoxylin and Eosin, Immunofluorescence, uniaxial accelerometer
Citation: Büchele F, Morawska MM, Schreglmann SR, Penner M, Muser M, Baumann CR, Noain D. Novel Rat Model of Weight Drop-Induced Closed Diffuse Traumatic Brain Injury Compatible with Electrophysiological Recordings of Vigilance StatesJ Neurotrauma. 2016 Jul 1;33(13):1171-80. doi: 10.1089\/neu.2015.4001. Epub 2015 Nov 13.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: open field test, Corticosterone level, Novel object recognition test, foot fault test, NeuN staining, Cresyl violet staining
Citation: Jamnia N, Urban JH, Stutzmann GE, Chiren SG, Reisenbigler E, Marr R, Peterson DA, Kozlowski DA. A Clinically Relevant Closed-Head Model of Single and Repeat Concussive Injury in the Adult Rat Using a Controlled Cortical Impact DeviceJ Neurotrauma. 2017 Apr 1;34(7):1351-1363. doi: 10.1089\/neu.2016.4517. Epub 2016 Dec 2.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: Contextual fear memory testing, Novel object recognition test, Sound-attenuated isolation, elevated zero maze apparatus, Immunohistochemistry (IHC), light/dark emergence task
Citation: Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast InjuryNeurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089\/neur.2021.0005. eCollection 2021. PMC8655798
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry, Novel object recognition test, Y-Maze, elevated plus maze test, staircase test
Citation: Qubty D, Rubovitch V, Benromano T, Ovadia M, Pick CG. Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain InjuryJ Mol Neurosci. 2021 Jan;71(1):178-186. doi: 10.1007\/s12031-020-01688-4. Epub 2020 Sep 8.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Morris Water Maze (MWM), Neurologic Deficit Scoring, Western Blot, Novel object recognition test, RT-PCR
Citation: Cheng T, Yang B, Li D, Ma S, Tian Y, Qu R, Zhang W, Zhang Y, Hu K, Guan F, Wang J. Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain InjuryCell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007\/s10571-015-0159-9. Epub 2015 Feb 1. PMC4481175
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterationsClin Exp Pharmacol Physiol. 2016 Nov;43(11):1107-1114. doi: 10.1111\/1440-1681.12650.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Elevated plus maze test, Histology, Novel object recognition test, Open field test, T-Maze, Western blot, infarct volume
Citation: Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A(3) receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injuryJ Neuroinflammation. 2020 Nov 12;17(1):339. doi: 10.1186\/s12974-020-02009-7. PMC7659122
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Lesniak A, Pick CG, Misicka A, Lipkowski AW, Sacharczuk M. Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)Neuropharmacology. 2016 Feb;101:506-18. doi: 10.1016\/j.neuropharm.2015.10.014. Epub 2015 Oct 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Corticosterone Enzyme Assay, Novel object recognition test, OxiSelect Total Antioxidant Capacity Assay, Y Maze, immunoblot
Citation: Doulames VM, Vilcans M, Lee S, Shea TB. Social interaction attenuates the extent of secondary neuronal damage following closed head injury in miceFront Behav Neurosci. 2015 Oct 15;9:275. doi: 10.3389\/fnbeh.2015.00275. eCollection 2015. PMC4606018
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Adhesion-Removal Test, beam walk, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), Novel object recognition test, open field test
Citation: Kuo CW, Chang MY, Liu HH, He XK, Chan SY, Huang YZ, Peng CW, Chang PK, Pan CY, Hsieh TH. Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in RatsFront Neural Circuits. 2021 Jun 14;15:693073. doi: 10.3389\/fncir.2021.693073. eCollection 2021. PMC8236591
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: 1H-MRS, Beam walk test, LC Model, Magnetic resonance imaging (MRI), Novel object recognition test, Open field exploratory
Citation: Singh K, Trivedi R, Haridas S, Manda K, Khushu S. Study of neurometabolic and behavioral alterations in rodent model of mild traumatic brain injury: a pilot studyNMR Biomed. 2016 Dec;29(12):1748-1758. doi: 10.1002\/nbm.3627. Epub 2016 Oct 25.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Enzyme-linked immunosorbent assay (ELISA), GC-MS analysis, Metabolomic Analysis, Y-maze, discrimination index, Novel object recognition test, open field test
Citation: Alqahtani F, Assiri MA, Mohany M, Imran I, Javaid S, Rasool MF, Shakeel W, Sivandzade F, Alanazi AZ, Al-Rejaie SS, Alshammari MA, Alasmari F, Alanazi MM, Alamri FF. Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse ModelBiomed Res Int. 2020 Dec 10;2020:3193725. doi: 10.1155\/2020\/3193725. eCollection 2020. PMC7749776
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Long Evans
Assessments: ELISA test, Immunohistochemistry, Morris water maze test, Novel object recognition test, open field test
Citation: Tadepalli SA, Bali ZK, Bruszt N, Nagy LV, Amrein K, Fazekas B, Büki A, Czeiter E, Hernádi I.Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in ratsBehav Brain Res. 2020 Jan 27;378:112268. doi: 10.1016/j.bbr.2019.112268. Epub 2019 Sep 30.10.1016/j.bbr.2019.112268
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Immunohistochemistry (IHC), Novel object recognition test, Hematoxylin and eosin
Citation: Ohta M, Higashi Y, Yawata T, Kitahara M, Nobumoto A, Ishida E, Tsuda M, Fujimoto Y, Shimizu K.Brain Res. 2013 Jan 15;1490:184-92. doi: 10.1016/j.brainres.2012.09.011. Epub 2012 Sep 13.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH, Pick CG. Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in miceJ Neuroinflammation. 2015 Mar 7;12:45. doi: 10.1186\/s12974-015-0237-4. PMC4352276
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz-Goldstein R, Toussia-Cohen S, Elpaz A, Rubovitch V, Pick CG. Immediate and delayed hyperbaric oxygen therapy as a neuroprotective treatment for traumatic brain injury in miceMol Cell Neurosci. 2017 Sep;83:74-82. doi: 10.1016\/j.mcn.2017.06.004. Epub 2017 Jul 8.
