On page 1 showing 1 ~ 20 out of 29 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: blood pH, Home Cage behavioral test, Immunohistochemistry (IHC), Nissl staining, Rectal temperature, TUNEL staining, Western blot, adhesive removal test, cylinder test, Evans blue dye, mean arterial blood pressure, RT–PCR
Citation: Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1417-30. doi: 10.1089\/neu.2013.3251. Epub 2014 Jul 7. PMC4132583
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Hematoxylin and Eosin, Neurological Severity Score (NSS), Nissl staining, Timm stain
Citation: Ezaki J, Shimada R, Shibuya M, Kibayashi K. Hippocampal neuronal degeneration in the traumatic brain injury mouse: non-trivial effect of scalp incisionNeurol Res. 2016 Nov;38(11):994-1002. doi: 10.1080\/01616412.2016.1228746. Epub 2016 Sep 10.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: modified Neurological Severity Score (mNSS), Neurological examination, Sensorimotor examination, Nissl staining, light/dark anxiety transition test, conditioned passive avoidance response, elevated plus-maze, histology, Hematoxylin and Eosin
Citation: Plekhova NG, Radkov IV, Zinoviev SV, Dyuizen IV, Baryshev AN, Shumatov VB. Effect of Mild Traumatic Brain Injury on Behavioral Reactions and Neocortical Morphology in RatsBull Exp Biol Med. 2021 Mar;170(5):672-676. doi: 10.1007\/s10517-021-05130-6. Epub 2021 Mar 31.
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Intracranial Pressure (ICP), Nissl staining, Fluoro-Jade B staining (FJB), NeuN staining, cerebral perfusion pressure, heart rate, mean arterial blood pressure (MAP)
Citation: Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanicsJ Neurotrauma. 2006 Feb;23(2):128-39. doi: 10.1089\/neu.2006.23.128.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry (IHC), Nissl staining, Western blot, Brain water content, grip test, spectrophotometer, Neurological Severity Score (NSS)
Citation: Liang J, Wu S, Xie W, He H. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathwayDrug Des Devel Ther. 2018 Apr 16;12:845-853. doi: 10.2147\/DDDT.S160046. eCollection 2018. PMC5907785
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl staining, Western blot, grip test, spectrophotometer
Citation: Fu C, Wang Q, Zhai X, Gao J. Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathwayDrug Des Devel Ther. 2018 Jan 5;12:77-84. doi: 10.2147\/DDDT.S154391. eCollection 2018. PMC5759853
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hang test, Immunofluorescence, Nissl staining, Western blot, tail suspension test
Citation: Selvakumar GP, Ahmed ME, Iyer SS, Thangavel R, Kempuraj D, Raikwar SP, Bazley K, Wu K, Khan A, Kukulka K, Bussinger B, Zaheer S, Burton C, James D, Zaheer A. Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain InjuryExp Neurobiol. 2020 Jun 30;29(3):230-248. doi: 10.5607\/en20017. PMC7344375
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ELISA, Immunofluorescence, Lesion volume, Nissl staining, Beam balance test, Brain water content, Prehensile traction test
Citation: Zhao GW, Wang Y, Li YC, Jiang ZL, Sun L, Xi X, He P, Wang GH, Xu SH, Ma DM, Ke KF.J Ethnopharmacol. 2014;151(1):694-703. doi: 10.1016/j.jep.2013.11.041. Epub 2013 Dec 1.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: TTC staining method, Current responses, Enzyme-linked immunosorbent assay, Nissl staining, brain water content, immunofluorescent staining, neurological severity score, wet and dry weight method
Citation: Zhai PP, Xu LH, Yang JJ, Jiang ZL, Zhao GW, Sun L, Wang GH, Li X.Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury.Neuropharmacology. 2015 Aug;95:1-11. doi: 10.1016/j.neuropharm.2015.02.026. Epub 2015 Mar 5.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Nissl and TTC stained, Nissl staining, lesion volume, modified Neurologic Severity Score, open field behavioral test, western blot analysis
Citation: Ghadiri T, Sharifzadeh M, Khodagholi F, Modarres Mousavi SM, Hassanzadeh G, Zarrindast MR, Gorji A.A novel traumatic brain injury model for induction of mild brain injury in rats.J Neurosci Methods. 2014 Aug 15;233:18-27. doi: 10.1016/j.jneumeth.2014.05.035. Epub 2014 Jun 4.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague–Dawley
Assessments: BBB permeability, ELISA, Electron microscopy, Gravimetric analysis, Neurochemical assays, Nissl staining, Western blot analysis, beam-balancing test, immunohistochemistry
Citation: Wang GH, Jiang ZL, Li YC, Li X, Shi H, Gao YQ, Vosler PS, Chen J.Free-radical scavenger edaravone treatment confers neuroprotection against traumatic brain injury in ratsJ Neurotrauma. 2011 Oct;28(10):2123-34. doi: 10.1089/neu.2011.1939. Epub 2011 Sep 27.PMC319136810.1089/neu.2011.1939
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl Staining, Western blot, Grip test, spectrophotometer
Citation: Zhai X, Ding Y, Wang Q, Zhang H, Li F. Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in MiceNeuroimmunomodulation. 2016;23(3):179-187. doi: 10.1159\/000448716. Epub 2016 Sep 20.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Hematoxylin and Eosin, Nissl staining
Citation: Zhào H, Liu Y, Zeng J, Li D, Huang Y. Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury - via endothelial nitric oxide synthase pathway regulationInt J Neurosci. 2018 Dec;128(12):1118-1127. doi: 10.1080\/00207454.2018.1486828. Epub 2018 Nov 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Nissl staining, Serum S100β, Neurological Severity Score (NSS)
Citation: Guo D, Li D, Li J, Li Y, Hu X, Guan F, Yang B. Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI miceNeurol Res. 2017 Sep;39(9):830-836. doi: 10.1080\/01616412.2017.1330815. Epub 2017 May 31.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, Immunohistochemistry (IHC), Lesion Volume, Morris Water Maze (MWM), Neurobehavioral Evaluation, Nissl staining, beam walk
Citation: Li D, Ma S, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F, Yang B, Wang J. Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain InjuryCell Mol Neurobiol. 2016 Oct;36(7):1045-55. doi: 10.1007\/s10571-015-0295-2. Epub 2016 Feb 17. PMC4967018
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam walk test, Estimated contusion volume, Nissl staining, Neuronal death, Gliosis rating, Tactile placing
Citation: Stibick DL, Feeney DM.J Neurotrauma. 2001 Mar;18(3):303-12. doi: 10.1089/08977150151070955.
TBI Model Type: Other
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Nissl staining, light microscope, silver staining, toluidine blue
Citation: Caron AM, Stephenson R. Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the ratNat Sci Sleep. 2015 Jun 22;7:63-72. doi: 10.2147\/NSS.S82888. eCollection 2015. PMC4482367
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Immunohistochemistry (IHC), Neurological evaluation, Nissl staining, TUNEL staining, Western blot, spectrophotometer
Citation: Wei W, Wang H, Wu Y, Ding K, Li T, Cong Z, Xu J, Zhou M, Huang L, Ding H, Wu H. Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injuryNeurochem Int. 2015 Aug;87:85-91. doi: 10.1016\/j.neuint.2015.06.003. Epub 2015 Jun 6.
