On page 1 showing 1 ~ 20 out of 44 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Array image analysis, Beam walk test, Cytokine array, Immunohistochemistry (IHC), Neurological Severity Score (NSS), confocal imaging, phospho-Akt array
Citation: Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F. Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injuryInt Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016\/j.intimp.2017.08.002. Epub 2017 Aug 12.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Neurological Severity Score (NSS), RT-PCR
Citation: Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC. The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in miceNeurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016\\/j.neulet.2014.10.037. Epub 2014 Oct 28.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Passive avoidance test, Neurological Severity Score (NSS), passive avoidance test
Citation: Khalin I, Jamari NL, Razak NB, Hasain ZB, Nor MA, Zainudin MH, Omar AB, Alyautdin R. A mouse model of weight-drop closed head injury: emphasis on cognitive and neurological deficiencyNeural Regen Res. 2016 Apr;11(4):630-5. doi: 10.4103\/1673-5374.180749. PMC4870921
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: EEG/EMG recording, Neurological Severity Score (NSS), Novel object recognition test, open field test, Hematoxylin and Eosin, Immunofluorescence, uniaxial accelerometer
Citation: Büchele F, Morawska MM, Schreglmann SR, Penner M, Muser M, Baumann CR, Noain D. Novel Rat Model of Weight Drop-Induced Closed Diffuse Traumatic Brain Injury Compatible with Electrophysiological Recordings of Vigilance StatesJ Neurotrauma. 2016 Jul 1;33(13):1171-80. doi: 10.1089\/neu.2015.4001. Epub 2015 Nov 13.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Cui CM, Gao JL, Cui Y, Sun LQ, Wang YC, Wang KJ, Li R, Tian YX, Cui JZ. Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic deathMol Med Rep. 2015 Aug;12(2):2323-8. doi: 10.3892\/mmr.2015.3611. Epub 2015 Apr 15.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6 (transgenic)
Assessments: Neurological Severity Score (NSS), Beam walk test, Blood ethanol assay, Blood gas analysis, Blood glial fibrillary acidic protein, Confocal images, Immunostaining, nitrocellulose-membrane sandwich immunoassay
Citation: Chandrasekar A, Olde Heuvel F, Wepler M, Rehman R, Palmer A, Catanese A, Linkus B, Ludolph A, Boeckers T, Huber-Lang M, Radermacher P, Roselli F. The Neuroprotective Effect of Ethanol Intoxication in Traumatic Brain Injury Is Associated with the Suppression of ErbB Signaling in Parvalbumin-Positive InterneuronsJ Neurotrauma. 2018 Nov 15;35(22):2718-2735. doi: 10.1089\/neu.2017.5270. Epub 2018 Jul 23.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Hematoxylin and Eosin, Neurological Severity Score (NSS), Nissl staining, Timm stain
Citation: Ezaki J, Shimada R, Shibuya M, Kibayashi K. Hippocampal neuronal degeneration in the traumatic brain injury mouse: non-trivial effect of scalp incisionNeurol Res. 2016 Nov;38(11):994-1002. doi: 10.1080\/01616412.2016.1228746. Epub 2016 Sep 10.
TBI Model Type: Fluid percussion injury model
Organism Species: rat
Organism Strain: Wistar
Assessments: Diffusion Tensor Imaging scan, Neurological Severity Score (NSS)
Citation: Nakuci J, McGuire M, Schweser F, Poulsen D, Muldoon SF. Differential Patterns of Change in Brain Connectivity Resulting from Severe Traumatic Brain InjuryBrain Connect. 2022 May 5. doi: 10.1089\/brain.2021.0168. Online ahead of print.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Amyloid precursor protein, Cortical contusion volume, Immunoglobulin, Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Neuroscore, Regional hippocampal neurodegeneration
Citation: Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studiesJ Neurotrauma. 2011 Nov;28(11):2245-62. doi: 10.1089\/neu.2010.1499. Epub 2011 Apr 21. PMC3218388
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Barnes Maze test, Enzyme-Linked Immunosorbent Assay (ELISA), Histology, LRR, Neurological Severity Score (NSS), open field test, Silver staining, Western blot, Rotarod test, passive avoidance task, thigmotaxis index
Citation: Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injuryMol Neurodegener. 2014 Dec 1;9:55. doi: 10.1186\/1750-1326-9-55. PMC4269957
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Brain water content, Hematoxylin and Eosin, qRT-PCR, Western blot, Neurological Severity Score (NSS), TUNEL staining
Citation: Li Z, Wang Y, Zeng G, Zheng X, Wang W, Ling Y, Tang H, Zhang J. Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in ratsAm J Transl Res. 2017 Dec 15;9(12):5653-5661. eCollection 2017. PMC5752915
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Cavalieri’s method, Hematoxylin and Eosin, Neurological Severity Score (NSS), ORT, Rotarod test, Western blot, Y Maze
Citation: Ji X, Peng D, Zhang Y, Zhang J, Wang Y, Gao Y, Lu N, Tang P. Astaxanthin improves cognitive performance in mice following mild traumatic brain injuryBrain Res. 2017 Mar 15;1659:88-95. doi: 10.1016\/j.brainres.2016.12.031. Epub 2016 Dec 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Evans blue staining, Immunohistochemistry (IHC), Neurological Severity Score (NSS), open field test, R(−)-apomorphine challenge, Rotarod test, Western blot
Citation: de Oliveira PA, Ben J, Matheus FC, Schwarzbold ML, Moreira ELG, Rial D, Walz R, Prediger RD. Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in miceBrain Res. 2017 May 15;1663:78-86. doi: 10.1016\/j.brainres.2017.03.002. Epub 2017 Mar 11.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry (IHC), Nissl staining, Western blot, Brain water content, grip test, spectrophotometer, Neurological Severity Score (NSS)
Citation: Liang J, Wu S, Xie W, He H. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathwayDrug Des Devel Ther. 2018 Apr 16;12:845-853. doi: 10.2147\/DDDT.S160046. eCollection 2018. PMC5907785
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Ma Y, Liu T, Fu J, Fu S, Hu C, Sun B, Fan X, Zhu J. Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain InjuryJ Nutr. 2019 Sep 1;149(9):1543-1552. doi: 10.1093\/jn\/nxz105.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Neurological Severity Score (NSS), RT-PCR, terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling
Citation: Wang YC, Xia QJ, Ba YC, Wang TY, LiN N, Zou Y, Shang FF, Zhou XF, Wang TH, Fu XM, Qi JG.Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.Cytotherapy. 2014 Jul;16(7):1000-10. doi: 10.1016/j.jcyt.2013.12.009. Epub 2014 Feb 28.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Neurological severity score (NSS)
Citation: Ohayon S, Boyko M, Saad A, Douvdevani A, Gruenbaum BF, Melamed I, Shapira Y, Teichberg VI, Zlotnik A.J Neurotrauma. 2012 Jan 20;29(2):261-7. doi: 10.1089/neu.2011.1938. Epub 2011 Dec 7.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawlay
Assessments: TUNEL staining, transmission electron microscope, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological Severity Score (NSS), Morris Water Maze (MWM), Western blot, Brain water content
Citation: Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injuryBiomed Pharmacother. 2017 Nov;95:885-893. doi: 10.1016\/j.biopha.2017.08.125. Epub 2017 Sep 10.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Autoradiography, Immunohistochemistry (IHC), Neurological Severity Score (NSS), hematoxylin and eosin, μPET
Citation: Israel I, Ohsiek A, Al-Momani E, Albert-Weissenberger C, Stetter C, Mencl S, Buck AK, Kleinschnitz C, Samnick S, Sirén AL. Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in miceJ Neuroinflammation. 2016 Jun 7;13(1):140. doi: 10.1186\/s12974-016-0604-9. PMC4897946
