On page 1 showing 1 ~ 20 out of 95 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain water content, Immunofluorescence, Immunohistochemistry (IHC), Mitochondrial MDA, SOD Content, Prussian Blue Staining, Reactive Oxygen Species Content, TUNEL staining, Western blot, dihydroethidium staining
Citation: Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain InjuryOxid Med Cell Longev. 2018 Aug 27;2018:4783602. doi: 10.1155\/2018\/4783602. eCollection 2018. PMC6129854
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: OF1
Assessments: Immunohistochemistry (IHC), Ventricular volume, antibody-coupled magnetic bead system, qRT-PCR
Citation: Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, Oré MV, Zuiani C, Milan V, Josserand J, Vontell R, Pansiot J, Degos V, Ikonomidou C, Titomanlio L, Hagberg H, Gressens P, Fleiss B. Role of microglia in a mouse model of paediatric traumatic brain injuryBrain Behav Immun. 2017 Jul;63:197-209. doi: 10.1016\/j.bbi.2016.11.001. Epub 2016 Nov 4. PMC5441571
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Novel object location test, Novel object recognition test, qPCR, Compound action potential (CAP) recording, Immunohistochemistry (IHC)
Citation: Bray CE, Witcher KG, Adekunle-Adegbite D, Ouvina M, Witzel M, Hans E, Tapp ZM, Packer J, Goodman E, Zhao F, Chunchai T, O'Neil S, Chattipakorn SC, Sheridan J, Kokiko-Cochran ON, Askwith C, Godbout JP. Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of MicrogliaJ Neurosci. 2022 May 18;42(20):4215-4228. doi: 10.1523\/JNEUROSCI.1910-21.2022. Epub 2022 Apr 19. PMC9121837
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Array image analysis, Beam walk test, Cytokine array, Immunohistochemistry (IHC), Neurological Severity Score (NSS), confocal imaging, phospho-Akt array
Citation: Chandrasekar A, Heuvel FO, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F. Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injuryInt Immunopharmacol. 2017 Oct;51:66-75. doi: 10.1016\/j.intimp.2017.08.002. Epub 2017 Aug 12.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Zinc staining
Citation: Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW. Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrusJ Trace Elem Med Biol. 2014 Oct;28(4):474-81. doi: 10.1016\/j.jtemb.2014.07.007. Epub 2014 Aug 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Hematoxylin and Eosin, Immunohistochemistry (IHC)
Citation: Feng Y, Gao Y, Wang T, Tao L, Qiu S, Zhao X. A longitudinal study of the mechanical properties of injured brain tissue in a mouse modelJ Mech Behav Biomed Mater. 2017 Jul;71:407-415. doi: 10.1016\/j.jmbbm.2017.04.008. Epub 2017 Apr 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Glasgow Coma Scale, TUNEL staining, Immunohistochemistry (IHC)
Citation: Zhaba WD, Deji QZ, Gao SQ, Han YL, Gao CC, Deng HJ, Liu XL, Li T, Zhou ML. Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injuryNeuroreport. 2021 Apr 7;32(6):472-478. doi: 10.1097\/WNR.0000000000001619.
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Diffusion tensor imaging(DTI), Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), T2-weighted imaging
Citation: Hutchinson EB, Schwerin SC, Radomski KL, Irfanoglu MO, Juliano SL, Pierpaoli CM. Quantitative MRI and DTI Abnormalities During the Acute Period Following CCI in the FerretShock. 2016 Sep;46(3 Suppl 1):167-76. doi: 10.1097\/SHK.0000000000000659. PMC4978600
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay, Immunohistochemistry (IHC), Neurological function, RT-PCR, Western blot, Differential gene expression analysis
Citation: Xiong LL, Hu Y, Zhang P, Zhang Z, Li LH, Gao GD, Zhou XF, Wang TH. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated NeuroplasticityMol Neurobiol. 2018 Mar;55(3):2696-2711. doi: 10.1007\/s12035-017-0551-1. Epub 2017 Apr 18.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: blood pH, Home Cage behavioral test, Immunohistochemistry (IHC), Nissl staining, Rectal temperature, TUNEL staining, Western blot, adhesive removal test, cylinder test, Evans blue dye, mean arterial blood pressure, RT–PCR
Citation: Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1417-30. doi: 10.1089\/neu.2013.3251. Epub 2014 Jul 7. PMC4132583
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Immunohistochemistry (IHC), Magnetic resonance imaging (MRI)
Citation: Tu TW, Lescher JD, Williams RA, Jikaria N, Turtzo LC, Frank JA. Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 1;34(1):248-256. doi: 10.1089\/neu.2015.4355. Epub 2016 Apr 11. PMC5198143
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Cui CM, Gao JL, Cui Y, Sun LQ, Wang YC, Wang KJ, Li R, Tian YX, Cui JZ. Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic deathMol Med Rep. 2015 Aug;12(2):2323-8. doi: 10.3892\/mmr.2015.3611. Epub 2015 Apr 15.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Prussian blue staining, Cerebral blood flow, COIS imaging, Immunohistochemistry (IHC), seizure activity
Citation: Bouley J, Chung DY, Ayata C, Brown RH Jr, Henninger N. Cortical Spreading Depression Denotes Concussion InjuryJ Neurotrauma. 2019 Apr 1;36(7):1008-1017. doi: 10.1089\/neu.2018.5844. Epub 2018 Aug 24. PMC6444888
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: Contextual fear memory testing, Novel object recognition test, Sound-attenuated isolation, elevated zero maze apparatus, Immunohistochemistry (IHC), light/dark emergence task
Citation: Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast InjuryNeurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089\/neur.2021.0005. eCollection 2021. PMC8655798
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Biochemical Assay, Brain water content, Hematoxylin and Eosin, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), qRT-PCR, TUNEL staining, Western blot
Citation: Tang Y, Dong X, Chen G, Ye W, Kang J, Tang Y, Feng Z. Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB\/NLRP3 Signaling PathwayNeurorehabil Neural Repair. 2020 Sep;34(9):831-843. doi: 10.1177\/1545968320948065. Epub 2020 Aug 10.
TBI Model Type: Fluid percussion injury model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: up-down method, von Frey filament, DNIC assessment, Immunohistochemistry (IHC)
Citation: Irvine KA, Peters CM, Vazey EM, Ferguson AR, Clark D. DREADD-mediated activation of the locus coeruleus restores descending nociceptive inhibition after traumatic brain injury in ratsJ Neurotrauma. 2022 Apr 12. doi: 10.1089\/neu.2021.0485. Online ahead of print.
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Amyloid precursor protein, Cortical contusion volume, Immunoglobulin, Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Neuroscore, Regional hippocampal neurodegeneration
Citation: Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studiesJ Neurotrauma. 2011 Nov;28(11):2245-62. doi: 10.1089\/neu.2010.1499. Epub 2011 Apr 21. PMC3218388
