On page 1 showing 1 ~ 20 out of 104 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay, Immunohistochemistry (IHC), Neurological function, RT-PCR, Western blot, Differential gene expression analysis
Citation: Xiong LL, Hu Y, Zhang P, Zhang Z, Li LH, Gao GD, Zhou XF, Wang TH. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated NeuroplasticityMol Neurobiol. 2018 Mar;55(3):2696-2711. doi: 10.1007\/s12035-017-0551-1. Epub 2017 Apr 18.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Zinc staining
Citation: Choi BY, Kim JH, Kim HJ, Lee BE, Kim IY, Sohn M, Suh SW. Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrusJ Trace Elem Med Biol. 2014 Oct;28(4):474-81. doi: 10.1016\/j.jtemb.2014.07.007. Epub 2014 Aug 4.
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Amyloid precursor protein, Cortical contusion volume, Immunoglobulin, Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Neuroscore, Regional hippocampal neurodegeneration
Citation: Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studiesJ Neurotrauma. 2011 Nov;28(11):2245-62. doi: 10.1089\/neu.2010.1499. Epub 2011 Apr 21. PMC3218388
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay(ELISA), Immunohistochemistry (IHC), hippocampal neurogenesis, microglia response, radial arm water maze, Rotarod
Citation: Chen MM, Zhao GW, He P, Jiang ZL, Xi X, Xu SH, Ma DM, Wang Y, Li YC, Wang GH. Improvement in the neural stem cell proliferation in rats treated with modified \Shengyu\ decoction may contribute to the neurorestorationJ Ethnopharmacol. 2015 May 13;165:9-19. doi: 10.1016\/j.jep.2015.02.037. Epub 2015 Feb 20.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459
TBI Model Type: Blast model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Immunohistochemistry (IHC)
Citation: Ahmed F, Gyorgy A, Kamnaksh A, Ling G, Tong L, Parks S, Agoston D. Time-dependent changes of protein biomarker levels in the cerebrospinal fluid after blast traumatic brain injuryElectrophoresis. 2012 Dec;33(24):3705-11. doi: 10.1002\/elps.201200299.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Lewis
Assessments: Immunohistochemistry (IHC)
Citation: Xu K, Yang Z, Shi R, Luo C, Zhang Z. Expression of aryl hydrocarbon receptor in rat brain lesions following traumatic brain injuryDiagn Pathol. 2016 Aug 9;11(1):72. doi: 10.1186\/s13000-016-0522-2. PMC4977631
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Glasgow Coma Scale, TUNEL staining, Immunohistochemistry (IHC)
Citation: Zhaba WD, Deji QZ, Gao SQ, Han YL, Gao CC, Deng HJ, Liu XL, Li T, Zhou ML. Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injuryNeuroreport. 2021 Apr 7;32(6):472-478. doi: 10.1097\/WNR.0000000000001619.
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Diffusion tensor imaging(DTI), Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), T2-weighted imaging
Citation: Hutchinson EB, Schwerin SC, Radomski KL, Irfanoglu MO, Juliano SL, Pierpaoli CM. Quantitative MRI and DTI Abnormalities During the Acute Period Following CCI in the FerretShock. 2016 Sep;46(3 Suppl 1):167-76. doi: 10.1097\/SHK.0000000000000659. PMC4978600
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Biochemical Assay, Brain water content, Hematoxylin and Eosin, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), qRT-PCR, TUNEL staining, Western blot
Citation: Tang Y, Dong X, Chen G, Ye W, Kang J, Tang Y, Feng Z. Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB\/NLRP3 Signaling PathwayNeurorehabil Neural Repair. 2020 Sep;34(9):831-843. doi: 10.1177\/1545968320948065. Epub 2020 Aug 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Accelerometer measurement, Immunohistochemistry (IHC)
Citation: Viano DC, Hamberger A, Bolouri H, Säljö A. Evaluation of three animal models for concussion and serious brain injuryAnn Biomed Eng. 2012 Jan;40(1):213-26. doi: 10.1007\/s10439-011-0386-2. Epub 2011 Oct 20.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834
TBI Model Type: Other
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Fluoro-Jade B staining (FJB), Histology, Locomotor behavior, Immunohistochemistry (IHC)
Citation: Turner RC, Naser ZJ, Lucke-Wold BP, Logsdon AF, Vangilder RL, Matsumoto RR, Huber JD, Rosen CL. Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cellsNeuroimmunol Neuroinflamm. 2017 Jan;4:6-15. doi: 10.20517\/2347-8659.2016.40. Epub 2017 Jan 20. PMC5289820
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: wet weight-dry weight, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC)
Citation: Weiss E, Dhir T, Collett A, Reola M, Kaplan M, Minimo C, Omert L, Leung P. Effect of complement C1-esterase inhibitor on brain edema and inflammation after mild traumatic brain injury in an animal modelClin Exp Emerg Med. 2020 Jun;7(2):87-94. doi: 10.15441\/ceem.19.050. Epub 2020 Jun 30. PMC7348678
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Evans blue dye, Immunohistochemistry (IHC), SOD activity, GSH-PX activity, MDA activity, qRT-PCR, Western blot, Brain water content
Citation: Zhang B, Wang B, Cao S, Wang Y. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative StressKorean J Physiol Pharmacol. 2015 Nov;19(6):491-7. doi: 10.4196\/kjpp.2015.19.6.491. Epub 2015 Oct 16. PMC4637351
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: CM-DiI dye, DiR dye, Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), TUNEL staining, Western blot, qRT-PCR
Citation: Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC. MSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in ratAging (Albany NY). 2020 Sep 23;12(18):18274-18296. doi: 10.18632\/aging.103692. Online ahead of print. PMC7585083
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Immunohistochemistry (IHC), Neurological examination, RRT, SPRT, Single pellet reaching task, Y-maze test
Citation: Yu KP, Yoon YS, Lee JG, Oh JS, Lee JS, Seog T, Lee HY. Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain InjuryAnn Rehabil Med. 2018 Aug;42(4):502-513. doi: 10.5535\/arm.2018.42.4.502. Epub 2018 Aug 31. PMC6129703
